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PKD1 (human)

Overview PKD1 a CAMK kinase of the PKD family. Cleavage by caspase-3 following DNA damage activates it and alters its subcellular localization. Sensitizes cells to apoptosis induced by genotoxic stress. Its cleavage is blocked in cells that over-express the anti-apoptotic Bcl-x(L) protein. Expression of a caspase-resistant mutant partially inhibits DNA damage-induced apoptosis. Its activation by TLR ligands is dependent on MyD88, IRAK4 and -1, but not TRAF6. Essential for MyD88-dependent proinflammatory immune responses. Activated by diacylglycerol and phorbol esters. Binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface. Colocalizes with F-actin at peripheral F-actin-rich structures in membrane ruffles at the edge of lamellipodia in cervical carcinoma cells. Substrates reportedly include critical regulatory proteins including CREB, SSH1L, CTNNB1, HDACs 5 and 7, PKD1, HPK1, MARK2, PIP5K2A, PPP1R14A Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.11.13; Autophagy; Protein kinase, CAMK; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); CAMK group; PKD family Cellular Component: Golgi apparatus; integral to plasma membrane; cytoplasm; plasma membrane; intercellular junction; cell cortex; trans-Golgi network; nucleus; cytosol Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; phospholipid binding; ATP binding Biological Process: apoptosis; protein amino acid autophosphorylation; protein kinase cascade; signal transduction; Golgi vesicle transport; activation of NF-kappaB transcription factor; phospholipid metabolic process; angiogenesis; inflammatory response; Golgi organization and biogenesis; integrin-mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; sphingolipid metabolic process; sphingolipid biosynthetic process; negative regulation of endocytosis; positive regulation of blood vessel endothelial cell migration; activation of CREB transcription factor; cell proliferation; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; peptidyl-serine phosphorylation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway Reference #:  Q15139 (UniProtKB) Alt. Names/Synonyms: KPCD1; nPKC-D1; nPKC-mu; PKC-MU; PKCM; PKD; PKD1; PRKCM; PRKD1; Protein kinase C mu type; protein kinase C, mu; Protein kinase D; protein kinase D1; Serine/threonine-protein kinase D1 Gene Symbols: PRKD1 Molecular weight: 101,704 Da Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PKD1 Substrate Sequence Logo

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	Sites Implicated In
apoptosis, inhibited: Y463‑p cell differentiation, altered: Y463‑p, S738‑p, S742‑p cell growth, altered: Y463‑p cell motility, altered: S738‑p, S742‑p transcription, altered: Y463‑p, S738‑p, S742‑p enzymatic activity, induced: Y95‑p, Y463‑p, S738‑p, S742‑p, S910‑p intracellular localization: S738‑p molecular association, regulation: Y95‑p, S205‑p, S208‑p, S219‑p, S223‑p, S738‑p, S742‑p phosphorylation: Y463‑p protein conformation: Y463‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		Y95-p	KFPECGFyGMYDKIL
4	73		S205-p	GVRRRRLsNVsLtGV
2	18		S208-p	RRRLsNVsLtGVSTI
0	6		T210-p	RLsNVsLtGVSTIRt
0	1		T214	VsLtGVSTIRtSsAE
0	1		T217-p	tGVSTIRtSsAELst
1	1		S219-p	VSTIRtSsAELstSA
1	0		S223-p	RtSsAELstSAPDEP
0	1		T224-p	tSsAELstSAPDEPL
0	1		S235-p	DEPLLQKsPsESFIG
0	1		S237-p	PLLQKsPsESFIGRE
0	1		S247	FIGREKRSNsQSYIG
2	6		S249-p	GREKRSNsQSYIGRP
0	2		K292-u	QYCKKLLkGLFRQGL
0	1		S345-p	DVVMEEGsDDNDSER
0	1		S379-p	MAECQNDsGEMQDPD
0	4		T395-p	DHEDANRtIsPSTsN
1	12		S397-p	EDANRtIsPSTsNNI
0	1		S399	ANRtIsPSTsNNIPL
0	1		T400	NRtIsPSTsNNIPLM
1	6		S401-p	RtIsPSTsNNIPLMR
1	1		S412-p	PLMRVVQsVKHTKRK
1	4		S421-p	KHTKRKSsTVMKEGW
1	1		Y432-p	KEGWMVHyTSKDTLR
0	1		Y443-p	DTLRKRHyWRLDsKC
0	1		S448-p	RHyWRLDsKCITLFQ
0	1		S460-p	LFQNDTGsRYyKEIP
7	0		Y463-p	NDTGsRYyKEIPLSE
0	2		S473-p	IPLSEILsLEPVKTS
1	0		Y502-p	TTANVVYyVGENVVN
0	1		S549-p	PVIPKGSsVGTGTNL
0	1		K612-a	TGRDVAIkIIDKLRF
0	2		K737-u	FARIIGEksFRRsVV
47	19		S738-p	ARIIGEksFRRsVVG
46	44		S742-p	GEksFRRsVVGTPAy
0	1		T746	FRRsVVGTPAyLAPE
0	4		Y749-p	sVVGTPAyLAPEVLR
0	1		S890-p	HLINPSAsHSDTPET
33	3		S910-p	KALGERVsIL_____

	mouse
Y93	KFPECGFYGLYDKIL
S203-p	GVRRRRLsNVsLtGL
S206-p	RRRLsNVsLtGLGtV
T208-p	RLsNVsLtGLGtVRT
T212-p	VsLtGLGtVRTASAE
T215	tGLGtVRTASAEFST
S217	LGtVRTASAEFSTSV
S221	RTASAEFSTSVPDEP
T222	TASAEFSTSVPDEPL
S241	SPGFEQKSPSESFIG
S243	GFEQKSPSESFIGRE
S253-p	FIGREKRsNsQSYIG
S255-p	GREKRsNsQSYIGRP
K298-u	QFCKKLLkGLFRQGL
S351	DVVMEEGSDDNDSER
G385	LAEGQSGGAEMQDPD
T401-p	DQEDSNRtIsPstsN
S403-p	EDSNRtIsPstsNNI
S405-p	SNRtIsPstsNNIPL
T406-p	NRtIsPstsNNIPLM
S407-p	RtIsPstsNNIPLMR
S418	PLMRVVQSVKHTKRR
S427-p	KHTKRRSsTVMKEGW
Y438	KEGWMVHYTSKDTLR
Y449	DTLRKRHYWRLDsKC
S454-p	RHYWRLDsKCITLFQ
S466	LFQNDTGSRYyKEIP
Y469-p	NDTGSRYyKEIPLSE
C479	IPLSEILCLEPAKPS
Y508	TTANVVYYVGENVVN
S555	PVIPKGSSVGSGSNS
K618	TGRDVAIKIIDKLRF
K743-u	FARIIGEksFRRsVV
S744-p	ARIIGEksFRRsVVG
S748-p	GEksFRRsVVGtPAy
T752-p	FRRsVVGtPAyLAPE
Y755-p	sVVGtPAyLAPEVLR
S896	HLISLSASHSDSPEA
S916-p	KALSERVsIL_____

	rat
Y93	KFPECGFYGLYDKIL
S203	GVRRRRLSNVSLTGL
S206	RRRLSNVSLTGLGTV
T208	RLSNVSLTGLGTVRT
T212	VSLTGLGTVRTASAE
T215	TGLGTVRTASAEFST
S217	LGTVRTASAEFSTSA
S221	RTASAEFSTSAPDEP
T222	TASAEFSTSAPDEPL
S241	SPGFEQKSPSESFIG
S243	GFEQKSPSESFIGRE
S253	FIGREKRSNSQSYVG
S255	GREKRSNSQSYVGRP
K298	QFCKKLLKGLFRQGL
S351	DVVMEEGSDDNDSER
G385	LAEGQSDGAEMQDPD
T401	DQEDSNRTISPSTSN
S403	EDSNRTISPSTSNNI
S405	SNRTISPSTSNNIPL
T406	NRTISPSTSNNIPLM
S407	RTISPSTSNNIPLMR
S418	PLMRVVQSVKHTKRR
S427	KHTKRRSSTVMKEGW
Y438	KEGWMVHYTSKDTLR
Y449	DTLRKRHYWRLDSKS
S454	RHYWRLDSKSITLFQ
S466	LFQNDTGSRYYKEIP
Y469	NDTGSRYYKEIPLSE
C479	IPLSEILCLEPAKPS
Y508	TTANVVYYVGENVVN
S555	PVIPKGSSVGSGTNS
K618	TGRDVAIKIIDKLRF
K743	FARIIGEKsFRRsVV
S744-p	ARIIGEKsFRRsVVG
S748-p	GEKsFRRsVVGTPAY
T752	FRRsVVGTPAYLAPE
Y755	sVVGTPAYLAPEVLR
S896	HLINLSASHGDSPEA
S916-p	KALSERVsIL_____

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