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Protein Page:
PKD1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKD1 a CAMK kinase of the PKD family. Cleavage by caspase-3 following DNA damage activates it and alters its subcellular localization. Sensitizes cells to apoptosis induced by genotoxic stress. Its cleavage is blocked in cells that over-express the anti-apoptotic Bcl-x(L) protein. Expression of a caspase-resistant mutant partially inhibits DNA damage-induced apoptosis. Its activation by TLR ligands is dependent on MyD88, IRAK4 and -1, but not TRAF6. Essential for MyD88-dependent proinflammatory immune responses. Activated by diacylglycerol and phorbol esters. Binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface. Colocalizes with F-actin at peripheral F-actin-rich structures in membrane ruffles at the edge of lamellipodia in cervical carcinoma cells. Substrates reportedly include critical regulatory proteins including CREB, SSH1L, CTNNB1, HDACs 5 and 7, PKD1, HPK1, MARK2, PIP5K2A, PPP1R14A Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; Autophagy; Protein kinase, CAMK; Kinase, protein; EC 2.7.11.13; CAMK group; PKD family
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; cell cortex; intercellular junction; trans-Golgi network; cytosol; nucleus
Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; ATP binding
Biological Process: integrin-mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; sphingolipid metabolic process; sphingolipid biosynthetic process; apoptosis; negative regulation of endocytosis; protein amino acid autophosphorylation; positive regulation of blood vessel endothelial cell migration; activation of CREB transcription factor; signal transduction; positive regulation of peptidyl-serine phosphorylation; Golgi vesicle transport; activation of NF-kappaB transcription factor; cell proliferation; positive regulation of osteoblast differentiation; peptidyl-serine phosphorylation; positive regulation of angiogenesis; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; inflammatory response; vascular endothelial growth factor receptor signaling pathway; Golgi organization and biogenesis
Reference #:  Q15139 (UniProtKB)
Alt. Names/Synonyms: KPCD1; nPKC-D1; nPKC-mu; PKC-MU; PKCM; PKD; PKD1; PRKCM; PRKD1; Protein kinase C mu type; protein kinase C, mu; Protein kinase D; protein kinase D1; Serine/threonine-protein kinase D1
Gene Symbols: PRKD1
Molecular weight: 101,704 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PKD1

Protein Structure Not Found.

Substrate Sequence Logo
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Sites Implicated In
apoptosis, inhibited: Y463‑p
cell differentiation, altered: Y463‑p, S738‑p, S742‑p
cell growth, altered: Y463‑p
cell motility, altered: S738‑p, S742‑p
transcription, altered: Y463‑p, S738‑p, S742‑p
transcription, induced: Y463‑p
enzymatic activity, induced: Y95‑p, Y463‑p, S738‑p, S742‑p, S910‑p
intracellular localization: S738‑p
molecular association, regulation: Y95‑p, S205‑p, S208‑p, S219‑p, S223‑p, S738‑p, S742‑p
phosphorylation: Y463‑p
protein conformation: Y463‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y95-p KFPECGFyGMYDKIL
5 99 S205-p GVRRRRLsNVsLtGV
2 24 S208-p RRRLsNVsLtGVSTI
0 6 T210-p RLsNVsLtGVSTIRt
0 1 T214 VsLtGVSTIRtSsAE
0 4 T217-p tGVSTIRtSsAELst
1 1 S219-p VSTIRtSsAELstsA
1 0 S223-p RtSsAELstsAPDEP
0 1 T224-p tSsAELstsAPDEPL
0 1 S225-p SsAELstsAPDEPLL
0 4 S235-p DEPLLQKsPsEsFIG
0 5 S237-p PLLQKsPsEsFIGRE
0 1 S239-p LQKsPsEsFIGREKR
0 2 S247-p FIGREKRsNsQSYIG
2 9 S249-p GREKRsNsQSYIGRP
0 2 K292-ub QYCKKLLkGLFRQGL
0 1 S345-p DVVMEEGsDDNDSER
0 1 S379-p MAECQNDsGEMQDPD
0 4 T395-p DHEDANRtIsPStsN
1 19 S397-p EDANRtIsPStsNNI
0 1 S399 ANRtIsPStsNNIPL
0 2 T400-p NRtIsPStsNNIPLM
1 13 S401-p RtIsPStsNNIPLMR
1 1 S412-p PLMRVVQsVKHTKRK
2 4 S421-p KHTKRKSstVMKEGW
0 1 T422-p HTKRKSstVMKEGWM
1 1 Y432-p KEGWMVHyTSKDTLR
0 1 Y443-p DTLRKRHyWRLDsKC
0 1 S448-p RHyWRLDsKCITLFQ
0 1 S460-p LFQNDTGsRYyKEIP
7 0 Y463-p NDTGsRYyKEIPLSE
0 2 S473-p IPLSEILsLEPVKTS
1 0 Y502-p TTANVVYyVGENVVN
0 1 S548-p MPVIPKGssVGTGTN
0 3 S549-p PVIPKGssVGTGTNL
0 1 K612-ac TGRDVAIkIIDKLRF
0 2 K737-ub FARIIGEksFRRsVV
50 29 S738-p ARIIGEksFRRsVVG
49 62 S742-p GEksFRRsVVGtPAy
0 6 T746-p FRRsVVGtPAyLAPE
0 4 Y749-p sVVGtPAyLAPEVLR
0 1 S890-p HLINPSAsHsDTPET
0 1 S892-p INPSAsHsDTPETEE
34 6 S910-p KALGERVsIL_____
2054 : Phospho-PKD/PKCmu (Ser744/748) Antibody
2054 : Phospho-PKD/PKCmu (Ser744/748) Antibody
2051 : Phospho-PKD/PKCmu (Ser916) Antibody
  mouse

 
Y93 KFPECGFYGLYDKIL
S203-p GVRRRRLsNVsLtGL
S206-p RRRLsNVsLtGLGtV
T208-p RLsNVsLtGLGtVRT
T212-p VsLtGLGtVRTASAE
T215 tGLGtVRTASAEFST
S217 LGtVRTASAEFSTSV
S221 RTASAEFSTSVPDEP
T222 TASAEFSTSVPDEPL
S223 ASAEFSTSVPDEPLL
S241 SPGFEQKSPSESFIG
S243 GFEQKSPSESFIGRE
S245 EQKSPSESFIGREKR
S253-p FIGREKRsNsQSYIG
S255-p GREKRsNsQSYIGRP
K298-ub QFCKKLLkGLFRQGL
S351 DVVMEEGSDDNDSER
G385 LAEGQSGGAEMQDPD
T401-p DQEDSNRtIsPstsN
S403-p EDSNRtIsPstsNNI
S405-p SNRtIsPstsNNIPL
T406-p NRtIsPstsNNIPLM
S407-p RtIsPstsNNIPLMR
S418 PLMRVVQSVKHTKRR
S427-p KHTKRRSsTVMKEGW
T428 HTKRRSsTVMKEGWM
Y438 KEGWMVHYTSKDTLR
Y449 DTLRKRHYWRLDsKC
S454-p RHYWRLDsKCITLFQ
S466 LFQNDTGSRYyKEIP
Y469-p NDTGSRYyKEIPLSE
C479 IPLSEILCLEPAKPS
Y508 TTANVVYYVGENVVN
S554 MPVIPKGSSVGSGSN
S555 PVIPKGSSVGSGSNS
K618 TGRDVAIKIIDKLRF
K743-ub FARIIGEksFRRsVV
S744-p ARIIGEksFRRsVVG
S748-p GEksFRRsVVGtPAy
T752-p FRRsVVGtPAyLAPE
Y755-p sVVGtPAyLAPEVLR
S896 HLISLSASHSDSPEA
S898 ISLSASHSDSPEAEE
S916-p KALSERVsIL_____
2054 : Phospho-PKD/PKCmu (Ser744/748) Antibody
2054 : Phospho-PKD/PKCmu (Ser744/748) Antibody
2051 : Phospho-PKD/PKCmu (Ser916) Antibody
  rat

 
Y93 KFPECGFYGLYDKIL
S203-p GVRRRRLsNVsLTGL
S206-p RRRLsNVsLTGLGTV
T208 RLsNVsLTGLGTVRT
T212 VsLTGLGTVRTASAE
T215 TGLGTVRTASAEFST
S217 LGTVRTASAEFSTSA
S221 RTASAEFSTSAPDEP
T222 TASAEFSTSAPDEPL
S223 ASAEFSTSAPDEPLL
S241 SPGFEQKSPSESFIG
S243 GFEQKSPSESFIGRE
S245 EQKSPSESFIGREKR
S253 FIGREKRSNSQSYVG
S255 GREKRSNSQSYVGRP
K298 QFCKKLLKGLFRQGL
S351 DVVMEEGSDDNDSER
G385 LAEGQSDGAEMQDPD
T401 DQEDSNRTIsPSTSN
S403-p EDSNRTIsPSTSNNI
S405 SNRTIsPSTSNNIPL
T406 NRTIsPSTSNNIPLM
S407 RTIsPSTSNNIPLMR
S418 PLMRVVQSVKHTKRR
S427 KHTKRRSSTVMKEGW
T428 HTKRRSSTVMKEGWM
Y438 KEGWMVHYTSKDTLR
Y449 DTLRKRHYWRLDSKS
S454 RHYWRLDSKSITLFQ
S466 LFQNDTGSRYYKEIP
Y469 NDTGSRYYKEIPLSE
C479 IPLSEILCLEPAKPS
Y508 TTANVVYYVGENVVN
S554 MPVIPKGSSVGSGTN
S555 PVIPKGSSVGSGTNS
K618 TGRDVAIKIIDKLRF
K743 FARIIGEKsFRRsVV
S744-p ARIIGEKsFRRsVVG
S748-p GEKsFRRsVVGTPAY
T752 FRRsVVGTPAYLAPE
Y755 sVVGTPAYLAPEVLR
S896 HLINLSASHGDSPEA
G898 INLSASHGDSPEAEE
S916-p KALSERVsIL_____
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