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Protein Page:
Exportin-5 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Exportin-5 mediates the nuclear export of proteins bearing double-stranded RNA binding domains and double-stranded RNA. Overexpression enhances RNA interference mediated by shRNAs and miRNAs. In the nucleus it binds cooperatively to its cargo and to Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. Exp5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Karyopherin; Nuclear export; Nuclear import
Cellular Component: nucleoplasm; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: protein binding; RNA binding; Ran GTPase binding; protein transporter activity; tRNA binding
Biological Process: RNA-mediated gene silencing; gene expression; protein export from nucleus
Reference #:  Q9HAV4 (UniProtKB)
Alt. Names/Synonyms: Exp5; exportin 5; Exportin-5; FLJ14239; FLJ32057; FLJ45606; KIAA1291; Ran-binding protein 21; RANBP21; XPO5
Gene Symbols: XPO5
Molecular weight: 136,311 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Exportin-5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K41 LKFCEEFKEKCPICV
0 2 K208-u VNKYQQVkTDTSQES
0 2 K396-a LLLAIIPkYLRASMT
0 3 K396-u LLLAIIPkYLRASMT
0 1 K407 ASMTNLVKMGFPSKT
0 1 K413 VKMGFPSKTDsPSCE
0 1 S416-p GFPSKTDsPSCEYSR
0 1 K590 FETVEESKAPRTRAV
0 1 K610 HACSSIIKMCRDYPQ
0 1 Y753-p AGGFVVGyTssGNPI
0 1 S755-p GFVVGyTssGNPIFR
0 1 S756-p FVVGyTssGNPIFRN
0 1 T782-p NLLALIRtHNtLyAP
0 1 T785-p ALIRtHNtLyAPEML
0 2 Y787-p IRtHNtLyAPEMLAK
0 1 K801-u KMAEPFTkALDMLDA
0 3 S826-p PLLELNDsPVFKTVL
0 2 K930-u LHMRLSQkWQVINQR
0 2 S1137-p DCKLLNPsLQkVADK
0 1 K1140-u LLNPsLQkVADKRRK
0 1 K1160-u LIAGCIGkPLGEQFR
0 1 K1173-u FRKEVHIkNLPSLFk
0 1 K1180-u kNLPSLFkKtKPMLE
0 2 T1182-p LPSLFkKtKPMLETE
  mouse

 
K41-u LKFCEEFkEKCPICV
K208 VNKYQQMKTDSSQEA
K396 ALLAVIPKYLRASMT
K396-u ALLAVIPkYLRASMT
K407-u ASMTNLVkMGFPSkT
K413-u VkMGFPSkTDSPSCE
S416 GFPSkTDSPSCEYSR
K590-u FESVGESkAPRTRAV
K610-u HACSSINkMCRDYPD
Y753 AGGFVVGYTPSGNPI
P755 GFVVGYTPSGNPIFR
S756 FVVGYTPSGNPIFRN
T782 NLLALVRTHNTLYTP
T785 ALVRTHNTLYTPEML
Y787 VRTHNTLYTPEMLTK
K801 KMAEPFTKALDIVES
H826 PLLEFNDHPVYRTTL
K930 LHMRLSQKWHVINQR
S1137 DCKLLNPSLQKAADK
K1140 LLNPSLQKAADKRRK
K1160 LIAGCIGKPLGEQFR
K1173 FRKEVHIKNLPWLFK
K1180 KNLPWLFKKPKPMLE
P1182 LPWLFKKPKPMLETE
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