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Protein Page:
Diaphanous-2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Diaphanous-2 Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. Isoform 3 interacts with RHOD in the GTP-bound form. Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes. Belongs to the formin homology family. Diaphanous subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: early endosome; cytosol
Molecular Function: Rho GTPase binding; actin binding; receptor binding
Biological Process: oogenesis; actin filament polymerization; multicellular organismal development; female gamete generation; cytokinesis
Reference #:  O60879 (UniProtKB)
Alt. Names/Synonyms: DIA; DIA2; DIAP2; DIAPH2; diaphanous 2; diaphanous homolog 2 (Drosophila); Diaphanous-related formin-2; DRF2; FLJ11167; mDia3; POF; POF2; Protein diaphanous homolog 2
Gene Symbols: DIAPH2
Molecular weight: 125,569 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  Microtubule Dynamics  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Diaphanous-2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S15-p ASGAGGGsEEPGGGR
0 1 S61-p DVRDRITsFRKsTVK
0 1 S65-p RITsFRKsTVKKEKP
1 0 T66 ITsFRKsTVKKEKPL
0 2 P77 EKPLIQHPIDSQVAM
0 1 Y94-p FPAAQPLyDERSLNL
0 1 K123-ac DMNLNEEkkAPLRNk
0 1 K124-ac MNLNEEkkAPLRNkD
0 1 K130-ac kkAPLRNkDFTTKRE
1 0 S189 CLESLRVSLTSNPVS
0 1 K220 LEKLLDKKQQENIDK
0 1 K227 KQQENIDKKNQYKLI
0 2 K238-ub YKLIQCLkAFMNNKF
0 1 T299 DKLLGAITTAAERNN
0 2 Y632-p GMKQKKMyKPEVSMK
0 1 K700-ac EKKTGPTkkKVKELR
0 1 K701-ac KKTGPTkkKVKELRI
1 0 S813 HINNIKPSIIAVTLA
1 0 T875 KSADQKTTLLHFIAD
0 1 T951 VEKMTSFTKTAREQY
0 1 K1074 AAFRDRRKRIPRNPD
0 2 S1092 VPLERSRSRHNGAIS
  Diaphanous-2 iso4  
S15 ASGAGGGSEEPGGGR
S61 DVRDRITSFRKStVK
S65 RITSFRKStVKKEKP
T66-p ITSFRKStVKKEKPL
P77 EKPLIQHPIDSQVAM
Y94 FPAAQPLYDERSLNL
K123 DMNLNEEKKAPLRNK
K124 MNLNEEKKAPLRNKD
K130 KKAPLRNKDFTTKRE
S196-p CLESLRVsLTSNPVS
K227 LEKLLDKKQQENIDK
K234 KQQENIDKKNQYKLI
K245 YKLIQCLKAFMNNKF
T306 DKLLGAITTAAERNN
Y639 GMKQKKMYKPEVSMK
K707 EKKTGPTKKKVKELR
K708 KKTGPTKKKVKELRI
S820-p HINNIKPsIIAVTLA
T882-p KSADQKTtLLHFIAD
T958 VEKMTSFTKTAREQY
K1081 AAFRDRRKRIPRNPV
- gap
  mouse

 
G18 AGGGGGGGEEHGGGR
S53 KLRDRITSFRKSATK
S57 RITSFRKSATKREKP
A58 ITSFRKSATKREKPV
S69-p EKPVIQHsIDYQTAV
H86 IPPALIVHDDRSLIL
K115 DMNLNEEKKAPLRKK
K116 MNLNEEKKAPLRKKD
K122 KKAPLRKKDFSIKRE
S188 CLESLRVSLTSHPVS
K219-ac LEKLLDKkQQENIDk
K226-ac kQQENIDkKNQYKVI
K237 YKVIQCLKAFMNNKF
T298-p DKLLGGItAAAELNN
Y629 GMKQKKLYKPDIPMK
K697 ENRSGPPKKKVKELR
K698 NRSGPPKKKVKELRI
S810 HVNNIKPSIIAVTLA
T872 KSADQKSTLLHFLAE
T948-p VEKMMSFtQNAREQY
K1071-ub AAFRDRRkRIPRNPD
S1089-p PPLERSRsRHNGAMS
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