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diaphanous 2 (human)

Overview diaphanous 2 Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. Isoform 3 interacts with RHOD in the GTP-bound form. Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes. Belongs to the formin homology family. Diaphanous subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; cytoplasm; early endosome; nucleolus; cytosol Molecular Function: Rho GTPase binding; actin binding; receptor binding Biological Process: oogenesis; actin filament polymerization; multicellular organismal development; cytokinesis; female gamete generation; cell differentiation Reference #:  O60879 (UniProtKB) Alt. Names/Synonyms: DIA; DIA2; DIAP2; DIAPH2; diaphanous 2; diaphanous homolog 2 (Drosophila); Diaphanous-related formin-2; DRF2; FLJ11167; mDia3; POF; POF2; Protein diaphanous homolog 2 Gene Symbols: DIAPH2 Molecular weight: 125,569 Da Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below diaphanous 2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S15-p	ASGAGGGsEEPGGGR
1	0		T66	ITSFRKSTVKKEKPL
0	2		P77	EKPLIQHPIDSQVAM
0	1		Y94-p	FPAAQPLyDERSLNL
0	1		K123-a	DMNLNEEkkAPLRNk
0	1		K124-a	MNLNEEkkAPLRNkD
0	1		K130-a	kkAPLRNkDFTTKRE
1	0		S189	CLESLRVSLTSNPVS
0	1		K220	LEKLLDKKQQENIDK
0	1		K227	KQQENIDKKNQYKLI
0	2		K238-u	YKLIQCLkAFMNNKF
0	1		T299	DKLLGAITTAAERNN
0	2		Y632-p	GMKQKKMyKPEVSMK
0	1		K700-a	EKKTGPTkkKVKELR
0	1		K701-a	KKTGPTkkKVKELRI
1	0		S813	HINNIKPSIIAVTLA
1	0		T875	KSADQKTTLLHFIAD
0	1		T951	VEKMTSFTKTAREQY
0	1		K1074	AAFRDRRKRIPRNPD
0	2		S1092-p	VPLERSRsRHNGAIS

	diaphanous 2 iso4
S15	ASGAGGGSEEPGGGR
T66-p	ITSFRKStVKKEKPL
P77	EKPLIQHPIDSQVAM
Y94	FPAAQPLYDERSLNL
K123	DMNLNEEKKAPLRNK
K124	MNLNEEKKAPLRNKD
K130	KKAPLRNKDFTTKRE
S196-p	CLESLRVsLTSNPVS
K227	LEKLLDKKQQENIDK
K234	KQQENIDKKNQYKLI
K245	YKLIQCLKAFMNNKF
T306	DKLLGAITTAAERNN
Y639	GMKQKKMYKPEVSMK
K707	EKKTGPTKKKVKELR
K708	KKTGPTKKKVKELRI
S820-p	HINNIKPsIIAVTLA
T882-p	KSADQKTtLLHFIAD
T958	VEKMTSFTKTAREQY
K1081	AAFRDRRKRIPRNPV
-	gap

	mouse
G18	AGGGGGGGEEHGGGR
A58	ITSFRKSATKREKPV
S69-p	EKPVIQHsIDYQTAV
H86	IPPALIVHDDRSLIL
K115	DMNLNEEKKAPLRKK
K116	MNLNEEKKAPLRKKD
K122	KKAPLRKKDFSIKRE
S188	CLESLRVSLTSHPVS
K219-a	LEKLLDKkQQENIDk
K226-a	kQQENIDkKNQYKVI
K237	YKVIQCLKAFMNNKF
T298-p	DKLLGGItAAAELNN
Y629	GMKQKKLYKPDIPMK
K697	ENRSGPPKKKVKELR
K698	NRSGPPKKKVKELRI
S810	HVNNIKPSIIAVTLA
T872	KSADQKSTLLHFLAE
T948-p	VEKMMSFtQNAREQY
K1071-u	AAFRDRRkRIPRNPD
S1089-p	PPLERSRsRHNGAMS

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