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Protein Page:
NRF1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NRF1 Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; cytoplasm
Biological Process: regulation of transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; generation of precursor metabolites and energy; organ regeneration; transcription, DNA-dependent; response to folic acid; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to lipopolysaccharide; cellular lipid metabolic process; response to electrical stimulus; response to estradiol stimulus
Reference #:  Q16656 (UniProtKB)
Alt. Names/Synonyms: Alpha palindromic-binding protein; Alpha-pal; NRF-1; NRF1; Nuclear respiratory factor 1
Gene Symbols: NRF1
Molecular weight: 53,541 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NRF1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S39 YTEHSMLSADEDSPS
0 1 S44 MLSADEDSPSSPEDT
0 1 S47 ADEDSPSSPEDTSYD
0 1 S56 EDTSYDDSDILNSTA
0 1 S99-p KRPHVFEsNPSIRKR
0 1 T118-p LLRKLRAtLDEytTR
0 1 Y122-p LRAtLDEytTRVGQQ
0 1 T123-p RAtLDEytTRVGQQA
0 4 S136-p QAIVLCIsPSKPNPV
0 2 S138 IVLCIsPSKPNPVFK
0 1 Y215 FIPEMLKYSTGRGkP
0 1 K221-ac KYSTGRGkPGWGkES
0 1 K226-ac RGkPGWGkESCKPIW
0 1 T259-p QKQRVSWtQALRTIV
  mouse

 
S39-p YTEHSMLsADEDsPS
S44-p MLsADEDsPSsPEDT
S47-p ADEDsPSsPEDTSYD
S56-p EDTSYDDsDILNSTA
S99 KRPHVFESNPSIRKR
T118 LLRKLRATLDEYTTR
Y122 LRATLDEYTTRVGQQ
T123 RATLDEYTTRVGQQA
S136-p QAIVLCIsPsKPNPV
S138-p IVLCIsPsKPNPVFK
Y215-p FIPEMLKySTGRGKP
K221 KySTGRGKPGWGKES
K226 RGKPGWGKESCKPIW
T259 QKQRVSWTQALRTIV
  rat

 
S39 YTEHSMLSADEDSPS
S44 MLSADEDSPSSPEDT
S47 ADEDSPSSPEDTSYD
S56 EDTSYDDSDILNSTA
S99 KRPHVFESNPSIRKR
T118 LLRKLRATLDEYTTR
Y122 LRATLDEYTTRVGQQ
T123 RATLDEYTTRVGQQA
S136 QAIVLCISPSKPNPV
S138 IVLCISPSKPNPVFK
Y215 FIPEMLKYSTGRGKP
K221 KYSTGRGKPGWGKES
K226 RGKPGWGKESCKPIW
T259 QKQRVSWTQALRTIV
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