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Protein Page:
NRF1 (human)

Overview
NRF1 Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: DNA binding
Biological Process: regulation of transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; organ regeneration; generation of precursor metabolites and energy; transcription, DNA-dependent; response to folic acid; response to hypoxia; response to lipopolysaccharide; cellular lipid metabolic process; response to electrical stimulus; response to estradiol stimulus
Reference #:  Q16656 (UniProtKB)
Alt. Names/Synonyms: Alpha palindromic-binding protein; Alpha-pal; NRF-1; NRF1; Nuclear respiratory factor 1
Gene Symbols: NRF1
Molecular weight: 53,541 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NRF1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S136-p QAIVLCIsPSKPNPV
0 1 S138 IVLCIsPSKPNPVFK
  mouse

 
S136-p QAIVLCIsPsKPNPV
S138-p IVLCIsPsKPNPVFK
  rat

 
S136 QAIVLCISPSKPNPV
S138 IVLCISPSKPNPVFK
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