an AGC kinase of the PKC family. A novel PKC: Ca2+ independent but still regulated by PS, DAG and phorbol esters. Contains 2 zinc-dependent phorbol-ester and DAG binding domains. Expressed in skeletal muscle and hematopoietic cells. May play a role in T cell receptor signaling and insulin resistance. Required for TCR-induced NF-kappaB activation in mature T lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, AGC; EC 188.8.131.52; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Delta subfamily
Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; ubiquitin-protein ligase activity; ATP binding
Biological Process: respiratory burst; axon guidance; phototransduction, visible light; apoptosis; positive regulation of interleukin-2 biosynthetic process; programmed cell death; negative regulation of insulin receptor signaling pathway; protein ubiquitination; positive regulation of NF-kappaB import into nucleus; response to organic cyclic substance; T cell receptor signaling pathway; protein amino acid phosphorylation; response to insulin stimulus; activation of NF-kappaB transcription factor; positive regulation of interleukin-4 production; regulation of transcription, DNA-dependent; tissue regeneration; positive regulation of stress fiber formation; regulation of G2/M transition of mitotic cell cycle; response to glucose stimulus; positive regulation of T cell proliferation; regulation of cell growth; inflammatory response; aging; cell structure disassembly during apoptosis; positive regulation of filopodium formation; positive regulation of interleukin-17 production; platelet activation; membrane protein ectodomain proteolysis; rhodopsin mediated signaling; regulation of rhodopsin mediated signaling; positive regulation of protein secretion; response to heat; regulation of vasoconstriction; response to hypoxia; innate immune response; positive regulation of T cell activation; blood coagulation
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.