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Protein Page:
PKCT (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKCT an AGC kinase of the PKC family. A novel PKC: Ca2+ independent but still regulated by PS, DAG and phorbol esters. Contains 2 zinc-dependent phorbol-ester and DAG binding domains. Expressed in skeletal muscle and hematopoietic cells. May play a role in T cell receptor signaling and insulin resistance. Required for TCR-induced NF-kappaB activation in mature T lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.13; AGC group; PKC family; Delta subfamily
Cellular Component: plasma membrane; immunological synapse; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; ubiquitin-protein ligase activity; ATP binding
Biological Process: positive regulation of interleukin-17 production; axon guidance; phototransduction, visible light; platelet activation; apoptosis; positive regulation of interleukin-2 biosynthetic process; membrane protein ectodomain proteolysis; protein ubiquitination; negative regulation of insulin receptor signaling pathway; T cell receptor signaling pathway; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; rhodopsin mediated signaling; positive regulation of interleukin-4 production; regulation of rhodopsin mediated signaling; regulation of transcription, DNA-dependent; innate immune response; positive regulation of T cell proliferation; positive regulation of T cell activation; regulation of cell growth; inflammatory response; blood coagulation; cell structure disassembly during apoptosis
Reference #:  Q04759 (UniProtKB)
Alt. Names/Synonyms: KPCT; MGC126514; MGC141919; nPKC-theta; PKC-theta; PKCQ; PKCtheta; PRKCQ; PRKCT; Protein kinase C theta type; protein kinase C, theta
Gene Symbols: PRKCQ
Molecular weight: 81,865 Da
Basal Isoelectric point: 7.69  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PKCT

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
signaling pathway regulation: T538‑p
transcription, altered: Y90‑p, T538‑p, S676‑p
enzymatic activity, induced: Y90‑p, T538‑p, S676‑p, S695‑p
intracellular localization: Y90‑p, T219‑p
molecular association, regulation: Y90‑p, S695‑p
protein stabilization: S695‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y28-p QGEAVNPyCAVLVKE
0 2 T51-p MYIQKKPtMYPPWDS
3 0 Y90-p SETTVELySLAERCR
0 1 Y121-p RMLMNARyFLEMSDT
1 1 T219-p SAINSREtMFHKERF
0 2 C303 ESTQQARCLRDtEQI
0 6 T307-p QARCLRDtEQIFREG
0 1 T307 QARCLRDTEQIFREG
0 3 S323-p VEIGLPCsIKNEARP
0 1 S348-p PQGISWEsPLDEVDK
0 1 N365 HLPEPELNKERPsLQ
0 1 P369 PELNKERPsLQIKLK
0 2 S370-p ELNKERPsLQIKLKI
0 2 K384-ac IEDFILHkMLGKGSF
0 15 T536-p NMLGDAKtNtFCGtP
12 16 T538-p LGDAKtNtFCGtPDy
0 2 T542-p KtNtFCGtPDyIAPE
0 12 Y545-p tFCGtPDyIAPEILL
0 1 S662-p VKSPFDCsNFDKEFL
0 1 N670 NFDKEFLNEKPRLsF
6 13 S676-p LNEKPRLsFADRALI
0 26 S685-p ADRALINsMDQNMFR
5 56 S695-p QNMFRNFsFMNPGME
1 0 R703 FMNPGMERLIS____
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9377 : Phospho-PKCtheta (Thr538) Antibody
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9376 : Phospho-PKCdelta/theta (Ser643/676) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  mouse

 
Y28 QGEAVNPYCAVLVKE
T51 MYIQKKPTMYPPWDS
Y90 SETTVELYSLAERCR
Y121 RMLMNARYFLEMSDT
T219-p SAINSREtMFHKERF
S303-p ESTQQARsLRDsEHI
S307-p QARsLRDsEHIFREG
S307 QARsLRDSEHIFREG
S323-p VEIGLPCsTKNETRP
S348 PQGISWDSPLDGSNK
S365-p GPPEPEVsMRRtsLQ
T369-p PEVsMRRtsLQLKLK
S370-p EVsMRRtsLQLKLKI
K384 IDDFILHKMLGKGSF
T536-p NMLGDAKtNtFCGTP
T538-p LGDAKtNtFCGTPDY
T542 KtNtFCGTPDYIAPE
Y545 tFCGTPDYIAPEILL
S662 VKSPYDCSNFDKEFL
S670 NFDKEFLSEKPRLsF
S676-p LSEKPRLsFADRALI
S685 ADRALINSMDQNMFS
S695-p QNMFSNFsFINPGME
T703-p FINPGMEtLICS___
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9377 : Phospho-PKCtheta (Thr538) Antibody
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9376 : Phospho-PKCdelta/theta (Ser643/676) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  rat

 
Y28 QGEAVNPYCAVLVKE
T51 MYIQKKPTMYPPWDS
Y90 SETTVELYSLAERCR
Y121 RMLMNARYFLEMSDT
T219-p SAINSREtMFHKERF
T303 ESTQQARTLRDsEHI
S307 QARTLRDSEHIFREG
S307-gl QARTLRDsEHIFREG
S323 IEISFPRSIKSETRP
S348 PQGICWESPLDGADK
N365 QPPEPEVNLQRASLQ
A369 PEVNLQRASLQLKLK
S370 EVNLQRASLQLKLKI
K384 IDDFILHKMLGKGSF
T536 NMLGDAKTNtFCGtP
T538-p LGDAKTNtFCGtPDY
T542-p KTNtFCGtPDYIAPE
Y545 tFCGtPDYIAPEILL
S662 VKSPYDCSNFDKEFL
S670-p NFDKEFLsEKPRLSF
S676 LsEKPRLSFADRALI
S685 ADRALINSMDQNMFS
S695 QNMFSNFSFINPGME
T703 FINPGMETLICS___
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