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PKCT (human)

Overview PKCT an AGC kinase of the PKC family. A novel PKC: Ca2+ independent but still regulated by PS, DAG and phorbol esters. Contains 2 zinc-dependent phorbol-ester and DAG binding domains. Expressed in skeletal muscle and hematopoietic cells. May play a role in T cell receptor signaling and insulin resistance. Required for TCR-induced NF-kappaB activation in mature T lymphocytes. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, AGC; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Delta subfamily Cellular Component: plasma membrane; immunological synapse; intracellular; nucleus; cytosol; neuromuscular junction; sarcolemma Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; protein kinase C activity; metal ion binding; ATP binding Biological Process: respiratory burst; axon guidance; apoptosis; positive regulation of interleukin-2 biosynthetic process; negative regulation of insulin receptor signaling pathway; positive regulation of NF-kappaB import into nucleus; T cell receptor signaling pathway; response to organic cyclic substance; protein amino acid phosphorylation; response to insulin stimulus; activation of NF-kappaB transcription factor; positive regulation of interleukin-4 production; regulation of transcription, DNA-dependent; tissue regeneration; positive regulation of stress fiber formation; regulation of G2/M transition of mitotic cell cycle; response to glucose stimulus; positive regulation of T cell proliferation; regulation of cell growth; inflammatory response; cell structure disassembly during apoptosis; aging; positive regulation of filopodium formation; positive regulation of interleukin-17 production; platelet activation; membrane protein ectodomain proteolysis; positive regulation of protein secretion; response to heat; regulation of vasoconstriction; response to hypoxia; positive regulation of T cell activation; blood coagulation Reference #:  Q04759 (UniProtKB) Alt. Names/Synonyms: KPCT; MGC126514; MGC141919; nPKC-theta; PKC-theta; PKCQ; PKCtheta; PRKCQ; PRKCT; Protein kinase C theta type; protein kinase C, theta Gene Symbols: PRKCQ Molecular weight: 81,865 Da Basal Isoelectric point: 7.69  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PKCT 1XJD - A=362-706 (human) 2ENJ - A=1-125 (human) 2ENN - A=144-213 (human) 2ENZ - A=227-284 (human) 2JED - A/B=361-706 (human) 4FKD - A=232-281 (mouse) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1XJD 2ENJ 2ENN 2ENZ 2JED  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
signaling pathway regulation: T538‑p transcription, altered: Y90‑p, T538‑p, S676‑p enzymatic activity, induced: Y90‑p, T538‑p, S676‑p, S695‑p intracellular localization: Y90‑p, T219‑p molecular association, regulation: Y90‑p, S695‑p protein stabilization: S695‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		T51-p	MYIQKKPtMYPPWDS
0	1		Y28-p	QGEAVNPyCAVLVKE
3	0		Y90-p	SETTVELySLAERCR
1	1		T219-p	SAINSREtMFHKERF
0	2		C303	ESTQQARCLRDtEQI
0	6		T307-p	QARCLRDtEQIFREG
0	1		T307	QARCLRDTEQIFREG
0	3		S323-p	VEIGLPCsIKNEARP
0	1		S348-p	PQGISWEsPLDEVDK
0	1		N365	HLPEPELNKERPsLQ
0	1		P369	PELNKERPsLQIKLK
0	2		S370-p	ELNKERPsLQIKLKI
0	2		K384-a	IEDFILHkMLGKGSF
0	17		T536-p	NMLGDAKtNtFCGtP
11	18		T538-p	LGDAKtNtFCGtPDy
0	1		T542-p	KtNtFCGtPDyIAPE
0	12		Y545-p	tFCGtPDyIAPEILL
0	1		S662-p	VKSPFDCsNFDKEFL
0	1		N670	NFDKEFLNEKPRLsF
5	11		S676-p	LNEKPRLsFADRALI
0	24		S685-p	ADRALINsMDQNMFR
5	56		S695-p	QNMFRNFsFMNPGME
1	0		R703	FMNPGMERLIS____

	mouse
T51	MYIQKKPTMYPPWDS
Y28	QGEAVNPYCAVLVKE
Y90	SETTVELYSLAERCR
T219-p	SAINSREtMFHKERF
S303-p	ESTQQARsLRDsEHI
S307-p	QARsLRDsEHIFREG
S307	QARsLRDSEHIFREG
S323-p	VEIGLPCsTKNETRP
S348	PQGISWDSPLDGSNK
S365-p	GPPEPEVsMRRtSLQ
T369-p	PEVsMRRtSLQLKLK
S370	EVsMRRtSLQLKLKI
K384	IDDFILHKMLGKGSF
T536-p	NMLGDAKtNtFCGTP
T538-p	LGDAKtNtFCGTPDY
T542	KtNtFCGTPDYIAPE
Y545	tFCGTPDYIAPEILL
S662	VKSPYDCSNFDKEFL
S670	NFDKEFLSEKPRLsF
S676-p	LSEKPRLsFADRALI
S685	ADRALINSMDQNMFS
S695-p	QNMFSNFsFINPGME
T703-p	FINPGMEtLICS___

	rat
T51	MYIQKKPTMYPPWDS
Y28	QGEAVNPYCAVLVKE
Y90	SETTVELYSLAERCR
T219-p	SAINSREtMFHKERF
T303	ESTQQARTLRDsEHI
S307	QARTLRDSEHIFREG
S307-g	QARTLRDsEHIFREG
S323	IEISFPRSIKSETRP
S348	PQGICWESPLDGADK
N365	QPPEPEVNLQRASLQ
A369	PEVNLQRASLQLKLK
S370	EVNLQRASLQLKLKI
K384	IDDFILHKMLGKGSF
T536	NMLGDAKTNtFCGTP
T538-p	LGDAKTNtFCGTPDY
T542	KTNtFCGTPDYIAPE
Y545	tFCGTPDYIAPEILL
S662	VKSPYDCSNFDKEFL
S670-p	NFDKEFLsEKPRLSF
S676	LsEKPRLSFADRALI
S685	ADRALINSMDQNMFS
S695	QNMFSNFSFINPGME
T703	FINPGMETLICS___

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