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NFkB-p65
a subunit of NF-kappa-B transcription complex, which plays a crucial role in inflammatory and immune responses. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. P65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Three splice-variant isoforms have been identified. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor; DNA binding protein; Nuclear receptor co-regulator |
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Cellular Component: transcription factor complex; protein complex; cytoplasm; cytosol; nucleus
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Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; identical protein binding; transcription activator binding; protein N-terminus binding; transcription factor binding; protein kinase binding; NF-kappaB binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; ubiquitin protein ligase binding; protein complex binding; chromatin binding; phosphate binding; transcription factor activity
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Biological Process: positive regulation of transcription, DNA-dependent; negative regulation of insulin receptor signaling pathway; defense response; activation of NF-kappaB transcription factor; response to organic substance; regulation of transcription, DNA-dependent; hair follicle development; positive regulation of cell proliferation; inflammatory response; positive regulation of Schwann cell differentiation; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; liver development; response to UV-B; organ morphogenesis; positive regulation of chondrocyte differentiation; positive regulation of interleukin-12 biosynthetic process; response to bacterium; response to muramyl dipeptide; regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein catabolic process; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
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Reference #:
Q04207 (UniProtKB)
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| Alt. Names/Synonyms: avian reticuloendotheliosis viral (v-rel) oncogene homolog A; Nfkb3; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; OTTMUSP00000017977; p65; p65 NF kappaB; p65 NF-kappa B; p65 NFkB; Rela; TF65; Transcription factor p65; v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
| Gene Symbols: Rela |
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Molecular weight: 60,212 Da
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Basal Isoelectric point: 5.5
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis
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B Cell Receptor Signaling
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Death Receptor Signaling
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Inhibition of Apoptosis
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NF-kB Signaling
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Signaling Pathways Activating p38 MAPK
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T Cell Receptor Signaling
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Toll-like Receptors Pathway
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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