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Protein Page:
PKCE (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKCE an AGC kinase of the PKC family. Calcium-independent, phospholipid-dependent. Activated by inflammatory mediators and involved in nociceptive functions. PKC-epsilon null mice display decreased hypoxic pulmonary vasoconstriction. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; AGC group; PKC family; Eta subfamily
Cellular Component: Golgi apparatus; cytoskeleton; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; cytosol; nucleus
Molecular Function: actin monomer binding; calcium-independent protein kinase C activity; signal transducer activity; protein binding; enzyme binding; protein kinase C activity; metal ion binding; enzyme activator activity; ethanol binding; ATP binding; receptor activator activity
Biological Process: nerve growth factor receptor signaling pathway; apoptosis; response to morphine; positive regulation of lipid catabolic process; signal transduction; protein amino acid phosphorylation; positive regulation of MAPKKK cascade; lipopolysaccharide-mediated signaling pathway; cell adhesion; regulation of peptidyl-tyrosine phosphorylation; positive regulation of cytokinesis; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of synaptic transmission, GABAergic; positive regulation of insulin secretion; cell cycle; positive regulation of actin filament polymerization; phospholipase C activation; cell division; release of sequestered calcium ion into cytosol; macrophage activation during immune response; innate immune response; blood coagulation
Reference #:  Q02156 (UniProtKB)
Alt. Names/Synonyms: KPCE; MGC125656; MGC125657; nPKC-epsilon; PKCE; PRKCE; Protein kinase C epsilon type; protein kinase C, epsilon
Gene Symbols: PRKCE
Molecular weight: 83,674 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKCE

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell cycle regulation: S346‑p, S368‑p
transcription, altered: S346‑p, S368‑p
enzymatic activity, induced: T566‑p, S729‑p
intracellular localization: T566‑p, S729‑p
molecular association, regulation: S346‑p, S368‑p, T566‑p, Y573‑p, S729‑p
phosphorylation: S350‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S24 SLKPTAWSLRHAVGP
0 1 S62 ATKQKTNSPAWHDEF
0 1 S132 VYVIIDLSGSSGEAP
0 1 S134 VIIDLSGSSGEAPKD
0 1 S135 IIDLSGSSGEAPKDN
0 1 T175 NGHKFMATYLRQPtY
0 1 Y176 GHKFMATYLRQPtYC
0 2 T181-p ATYLRQPtYCSHCRD
0 2 T228-p AGLKKQEtPDQVGsQ
1 1 S234-p EtPDQVGsQRFSVNM
0 5 Y250 HKFGIHNYKVPTFCD
0 1 S261-p TFCDHCGsLLWGLLR
0 1 T286-p NVHRRCEtNVAPNCG
1 0 T286 NVHRRCETNVAPNCG
0 3 T309-p VLADLGVtPDKITNs
0 1 K312 DLGVtPDKITNsGQR
1 2 S316-p tPDKITNsGQRRkKL
1 0 K321-ub TNsGQRRkKLIAGAE
0 5 S329-p KLIAGAEsPQPAsGS
0 2 S334-p AEsPQPAsGSsPsEE
0 6 S337-p PQPAsGSsPsEEDRs
0 1 S339-p PAsGSsPsEEDRsKs
0 3 S344-p sPsEEDRsKsAPTsP
2 5 S346-p sEEDRsKsAPTsPCD
0 1 S346 sEEDRsKSAPTsPCD
0 4 T349 DRsKsAPTsPCDQEI
0 1 T349 DRsKsAPTsPCDQEI
1 7 S350-p RsKsAPTsPCDQEIK
0 1 S350 RsKsAPTSPCDQEIK
3 7 S368-p NNIRKALsFDNRGEE
1 0 S368 NNIRKALSFDNRGEE
1 0 S380 GEEHRAASSPDGQLM
0 2 P382 EHRAASSPDGQLMsP
0 8 S388-p SPDGQLMsPGENGEV
1 0 S418 IKVLGKGSFGkVMLA
0 1 K421-ac LGKGSFGkVMLAELK
0 1 K430-ac MLAELKGkDEVyAVK
0 2 Y434-p LKGkDEVyAVKVLKK
1 0 T453 QDDDVDCTMTEKRIL
1 0 Y488 RLFFVMEYVNGGDLM
1 0 T517 RFYAAEVTSALMFLH
6 2 T566-p LNGVTTTtFCGTPDy
1 0 Y573-p tFCGTPDyIAPEILQ
0 1 S636 WLSKEAVSILKAFMT
0 1 T643 SILKAFMTKNPHKRL
1 3 T703 NNFDQDFTREEPVLt
3 43 T710-p TREEPVLtLVDEAIV
1 0 T710 TREEPVLTLVDEAIV
16 15 S729-p QEEFKGFsYFGEDLM
0 2 Y730 EEFKGFsYFGEDLMP
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  mouse

 
S24-p SLKPTAWsLRHAVGP
S62-p ATKQKTNsPAWHDEF
S132 VYVIIDLSGSSGEAP
S134 VIIDLSGSSGEAPKD
S135 IIDLSGSSGEAPKDN
T175 NGHKFMATYLRQPTY
Y176 GHKFMATYLRQPTYC
T181 ATYLRQPTYCSHCRD
T228-p AGLKKQEtPDEVGsQ
S234-p EtPDEVGsQRFSVNM
Y250 HKFGIHNYKVPTFCD
S261 TFCDHCGSLLWGLLR
T286 NVHRRCETNVAPNCG
T286 NVHRRCETNVAPNCG
T309 VLADLGVTPDkITNs
K312-ub DLGVTPDkITNsGQR
S316-p TPDkITNsGQRRKKL
K321 TNsGQRRKKLAAGAE
S329-p KLAAGAEsPQPAsGN
S334-p AEsPQPAsGNsPSED
S337-p PQPAsGNsPSEDDRs
S339 PAsGNsPSEDDRsKs
S344-p sPSEDDRsKsAPtsP
S346-p SEDDRsKsAPtsPCD
S346 SEDDRsKSAPtsPCD
T349-p DRsKsAPtsPCDQEL
T349 DRsKsAPTsPCDQEL
S350-p RsKsAPtsPCDQELK
S350 RsKsAPtSPCDQELK
S368-p NNIRKALsFDNRGEE
S368 NNIRKALSFDNRGEE
S380 GEEHRASSAtDGQLA
T382-p EHRASSAtDGQLAsP
S388-p AtDGQLAsPGENGEV
S418 IKVLGKGSFGKVMLA
K421 LGKGSFGKVMLAELK
K430 MLAELKGKDEVYAVK
Y434 LKGKDEVYAVKVLKK
T453 QDDDVDCTMTEKRIL
Y488 RLFFVMEYVNGGDLM
T517 RFYAAEVTSALMFLH
T566-p MNGVTTTtFCGTPDy
Y573-p tFCGTPDyIAPEILQ
S636 WLSKEAVSILKAFMT
T643 SILKAFMTKNPHKRL
T703-p NNFDQDFtREEPILt
T710-p tREEPILtLVDEAII
T710 tREEPILTLVDEAII
S729-p QEEFKGFsyFGEDLM
Y730-p EEFKGFsyFGEDLMP
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  rat

 
S24 SLKPTAWSLRHAVGP
S62 ATKQKTNSPAWHDEF
S132-gl VYVIIDLsGssGEAP
S134-gl VIIDLsGssGEAPKD
S135-gl IIDLsGssGEAPKDN
T175-p NGHKFMAtyLRQPTY
Y176-p GHKFMAtyLRQPTYC
T181 AtyLRQPTYCSHCRD
T228 AGLKKQETPDEVGSQ
S234 ETPDEVGSQRFSVNM
Y250-p HKFGIHNyKVPTFCD
S261 TFCDHCGSLLWGLLR
T286 NVHRRCETNVAPNCG
T286-gl NVHRRCEtNVAPNCG
T309 VLADLGVTPDKITNS
K312 DLGVTPDKITNSGQR
S316 TPDKITNSGQRRKKL
K321 TNSGQRRKKLAAGAE
S329 KLAAGAESPQPASGN
S334 AESPQPASGNSPSED
S337 PQPASGNSPSEDDRS
S339 PASGNSPSEDDRSKs
S344 SPSEDDRSKsAPtsP
S346 SEDDRSKSAPtsPCD
S346-gl SEDDRSKsAPtsPCD
T349 DRSKsAPTsPCDQEL
T349-gl DRSKsAPtsPCDQEL
S350 RSKsAPtSPCDQELK
S350-gl RSKsAPtsPCDQELK
S368 NNIRKALSFDNRGEE
S368-gl NNIRKALsFDNRGEE
S380-p GEEHRASsSTDGQLA
T382 EHRASsSTDGQLASP
S388 STDGQLASPGENGEV
S418-gl IKVLGKGsFGKVMLA
K421 LGKGsFGKVMLAELK
K430 MLAELKGKDEVYAVK
Y434 LKGKDEVYAVKVLKK
T453-gl QDDDVDCtMTEKRIL
Y488-p RLFFVMEyVNGGDLM
T517-gl GFYAAEVtSALMFLH
T566 LNGVTTTTFCGTPDY
Y573 TFCGTPDYIAPEILQ
S636-p WLSKEAVsILKAFMt
T643-p sILKAFMtKNPHKRL
T703-p NNFDQDFtREEPILt
T710-p tREEPILtLVDEAIV
T710-gl tREEPILtLVDEAIV
S729-p QEEFKGFsYFGEDLM
Y730 EEFKGFsYFGEDLMP
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
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