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PKCE (human)

Overview PKCE an AGC kinase of the PKC family. Calcium-independent, phospholipid-dependent. Activated by inflammatory mediators and involved in nociceptive functions. PKC-epsilon null mice display decreased hypoxic pulmonary vasoconstriction. Note: This description may include information from UniProtKB. Protein type: Protein kinase, AGC; EC 2.7.11.13; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Eta subfamily Cellular Component: Golgi membrane; Golgi apparatus; cytoskeleton; mitochondrion; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleus; cytosol Molecular Function: actin monomer binding; calcium-independent protein kinase C activity; signal transducer activity; protein kinase C activity; enzyme binding; metal ion binding; enzyme activator activity; ethanol binding; protein kinase binding; SH3 domain binding; receptor activator activity; ATP binding Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of synaptic transmission, GABAergic; response to morphine; positive regulation of insulin secretion; positive regulation of lipid catabolic process; signal transduction; cell cycle; protein amino acid phosphorylation; positive regulation of actin filament polymerization; positive regulation of MAPKKK cascade; phospholipase C activation; cell division; release of sequestered calcium ion into cytosol; induction of apoptosis; macrophage activation during immune response; lipopolysaccharide-mediated signaling pathway; cell adhesion; blood coagulation; regulation of peptidyl-tyrosine phosphorylation Reference #:  Q02156 (UniProtKB) Alt. Names/Synonyms: KPCE; MGC125656; MGC125657; nPKC-epsilon; PKCE; PRKCE; Protein kinase C epsilon type; protein kinase C, epsilon Gene Symbols: PRKCE Molecular weight: 83,674 Da Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PKCE 2WH0 - Q/R=342-372 (human) 1GMI - A=1-136 (rat) Substrate Sequence Logo

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	Sites Implicated In
cell cycle regulation: S346‑p, S368‑p transcription, altered: S346‑p, S368‑p enzymatic activity, induced: T566‑p, S729‑p intracellular localization: T566‑p, S729‑p molecular association, regulation: S346‑p, S368‑p, T566‑p, Y573‑p, S729‑p phosphorylation: S350‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S24	SLKPTAWSLRHAVGP
0	1		S62	ATKQKTNSPAWHDEF
0	1		S132	VYVIIDLSGSSGEAP
0	1		S134	VIIDLSGSSGEAPKD
0	1		S135	IIDLSGSSGEAPKDN
0	1		T175	NGHKFMATYLRQPtY
0	1		Y176	GHKFMATYLRQPtYC
0	2		T181-p	ATYLRQPtYCSHCRD
0	2		T228-p	AGLKKQEtPDQVGsQ
1	1		S234-p	EtPDQVGsQRFSVNM
0	5		Y250	HKFGIHNYKVPTFCD
1	0		T286	NVHRRCETNVAPNCG
0	2		T309-p	VLADLGVtPDKITNs
0	1		K312	DLGVtPDKITNsGQR
1	2		S316-p	tPDKITNsGQRRKKL
0	4		S329-p	KLIAGAEsPQPAsGS
0	2		S334-p	AEsPQPAsGSsPsEE
0	5		S337-p	PQPAsGSsPsEEDRs
0	1		S339-p	PAsGSsPsEEDRsKs
0	3		S344-p	sPsEEDRsKsAPTsP
2	5		S346-p	sEEDRsKsAPTsPCD
0	1		S346	sEEDRsKSAPTsPCD
0	4		T349	DRsKsAPTsPCDQEI
0	1		T349	DRsKsAPTsPCDQEI
1	7		S350-p	RsKsAPTsPCDQEIK
0	1		S350	RsKsAPTSPCDQEIK
3	5		S368-p	NNIRKALsFDNRGEE
1	0		S368	NNIRKALSFDNRGEE
1	0		S380	GEEHRAASSPDGQLM
0	2		P382	EHRAASSPDGQLMsP
0	7		S388-p	SPDGQLMsPGENGEV
1	0		S418	IKVLGKGSFGkVMLA
0	1		K421-a	LGKGSFGkVMLAELK
0	1		K430-a	MLAELKGkDEVyAVK
0	2		Y434-p	LKGkDEVyAVKVLKK
1	0		T453	QDDDVDCTMTEKRIL
1	0		Y488	RLFFVMEYVNGGDLM
1	0		T517	RFYAAEVTSALMFLH
6	1		T566-p	LNGVTTTtFCGTPDy
1	0		Y573-p	tFCGTPDyIAPEILQ
0	1		S636	WLSKEAVSILKAFMT
0	1		T643	SILKAFMTKNPHKRL
1	2		T703	NNFDQDFTREEPVLt
3	38		T710-p	TREEPVLtLVDEAIV
1	0		T710	TREEPVLTLVDEAIV
15	11		S729-p	QEEFKGFsYFGEDLM
0	1		Y730	EEFKGFsYFGEDLMP

	mouse
S24-p	SLKPTAWsLRHAVGP
S62-p	ATKQKTNsPAWHDEF
S132	VYVIIDLSGSSGEAP
S134	VIIDLSGSSGEAPKD
S135	IIDLSGSSGEAPKDN
T175	NGHKFMATYLRQPTY
Y176	GHKFMATYLRQPTYC
T181	ATYLRQPTYCSHCRD
T228-p	AGLKKQEtPDEVGsQ
S234-p	EtPDEVGsQRFSVNM
Y250	HKFGIHNYKVPTFCD
T286	NVHRRCETNVAPNCG
T309	VLADLGVTPDkITNs
K312-u	DLGVTPDkITNsGQR
S316-p	TPDkITNsGQRRKKL
S329-p	KLAAGAEsPQPAsGN
S334-p	AEsPQPAsGNsPSED
S337-p	PQPAsGNsPSEDDRs
S339	PAsGNsPSEDDRsKs
S344-p	sPSEDDRsKsAPtsP
S346-p	SEDDRsKsAPtsPCD
S346	SEDDRsKSAPtsPCD
T349-p	DRsKsAPtsPCDQEL
T349	DRsKsAPTsPCDQEL
S350-p	RsKsAPtsPCDQELK
S350	RsKsAPtSPCDQELK
S368-p	NNIRKALsFDNRGEE
S368	NNIRKALSFDNRGEE
S380	GEEHRASSAtDGQLA
T382-p	EHRASSAtDGQLAsP
S388-p	AtDGQLAsPGENGEV
S418	IKVLGKGSFGKVMLA
K421	LGKGSFGKVMLAELK
K430	MLAELKGKDEVYAVK
Y434	LKGKDEVYAVKVLKK
T453	QDDDVDCTMTEKRIL
Y488	RLFFVMEYVNGGDLM
T517	RFYAAEVTSALMFLH
T566-p	MNGVTTTtFCGTPDy
Y573-p	tFCGTPDyIAPEILQ
S636	WLSKEAVSILKAFMT
T643	SILKAFMTKNPHKRL
T703-p	NNFDQDFtREEPILt
T710-p	tREEPILtLVDEAII
T710	tREEPILTLVDEAII
S729-p	QEEFKGFsyFGEDLM
Y730-p	EEFKGFsyFGEDLMP

	rat
S24	SLKPTAWSLRHAVGP
S62	ATKQKTNSPAWHDEF
S132-g	VYVIIDLsGssGEAP
S134-g	VIIDLsGssGEAPKD
S135-g	IIDLsGssGEAPKDN
T175-p	NGHKFMAtyLRQPTY
Y176-p	GHKFMAtyLRQPTYC
T181	AtyLRQPTYCSHCRD
T228	AGLKKQETPDEVGSQ
S234	ETPDEVGSQRFSVNM
Y250-p	HKFGIHNyKVPTFCD
T286-g	NVHRRCEtNVAPNCG
T309	VLADLGVTPDKITNS
K312	DLGVTPDKITNSGQR
S316	TPDKITNSGQRRKKL
S329	KLAAGAESPQPASGN
S334	AESPQPASGNSPSED
S337	PQPASGNSPSEDDRS
S339	PASGNSPSEDDRSKs
S344	SPSEDDRSKsAPtsP
S346	SEDDRSKSAPtsPCD
S346-g	SEDDRSKsAPtsPCD
T349	DRSKsAPTsPCDQEL
T349-g	DRSKsAPtsPCDQEL
S350	RSKsAPtSPCDQELK
S350-g	RSKsAPtsPCDQELK
S368	NNIRKALSFDNRGEE
S368-g	NNIRKALsFDNRGEE
S380-p	GEEHRASsSTDGQLA
T382	EHRASsSTDGQLASP
S388	STDGQLASPGENGEV
S418-g	IKVLGKGsFGKVMLA
K421	LGKGsFGKVMLAELK
K430	MLAELKGKDEVYAVK
Y434	LKGKDEVYAVKVLKK
T453-g	QDDDVDCtMTEKRIL
Y488-p	RLFFVMEyVNGGDLM
T517-g	GFYAAEVtSALMFLH
T566	LNGVTTTTFCGTPDY
Y573	TFCGTPDYIAPEILQ
S636-p	WLSKEAVsILKAFMt
T643-p	sILKAFMtKNPHKRL
T703	NNFDQDFTREEPILt
T710	TREEPILTLVDEAIV
T710-g	TREEPILtLVDEAIV
S729-p	QEEFKGFsYFGEDLM
Y730	EEFKGFsYFGEDLMP

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