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TNF-R2 (human)

Overview TNF-R2 Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Receptor, cytokine; Membrane protein, integral Cellular Component: integral to membrane; plasma membrane; extracellular region; lipid raft Molecular Function: protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding Biological Process: apoptosis; negative regulation of inflammatory response; RNA destabilization; inflammatory response; positive regulation of membrane protein ectodomain proteolysis Reference #:  P20333 (UniProtKB) Alt. Names/Synonyms: CD120b; p75; p75 TNF receptor; p75TNFR; p80 TNF-alpha receptor; soluble TNFR1B variant 1; TBP-2; TBPII; TNF-R-II; TNF-R2; TNF-R75; TNF-RII; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRSF1B; TNR1B; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor superfamily member 1b, membrane form; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2 Gene Symbols: TNFRSF1B Molecular weight: 48,291 Da Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states CST Pathways:  Death Receptor Signaling  |  NF-kB Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TNF-R2 1CA9 - G/H=420-428 (human) 3ALQ - S/W/T/R/V/U=33-205 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1CA9 3ALQ  |  Phospho3D  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
inhibition: T436‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S221-p	VHLPQPVsTRSQHTQ
1	0		T436-p	AFRSQLEtPETLLGS

	mouse
P223	LYVSQPEPTRSQPLD
T438	PSQSPCETTETLQSH

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