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NEK7 (human)

Overview NEK7 a protein kinase of the NEK family. Phosphorylates and activates p70S6 kinase. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, Other; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; NEK family Cellular Component: spindle pole; microtubule; microtubule organizing center; nucleus Molecular Function: protein serine/threonine kinase activity; metal ion binding; ATP binding Biological Process: regulation of mitotic cell cycle; cytokinesis; spindle assembly; protein amino acid phosphorylation Reference #:  Q8TDX7 (UniProtKB) Alt. Names/Synonyms: NEK7; Never in mitosis A-related kinase 7; NIMA (never in mitosis gene a)-related kinase 7; NimA-related protein kinase 7; Serine/threonine-protein kinase Nek7 Gene Symbols: NEK7 Molecular weight: 34,551 Da Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NEK7 2WQM - A=1-302 (human) 2WQN - A=1-302 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2WQM 2WQN  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: Y97‑p enzymatic activity, inhibited: Y97‑p protein conformation: Y97‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S5-p	___MDEQsQGMQGPP
0	1		T30-p	RPDMGYNtLANFRIE
0	1		K74	IFDLMDAKARADCIK
1	0		Y97-p	NHPNVIKyYASFIED
0	1		S147-p	KYFVQLCsALEHMHS
0	4		S187-p	LGLGRFFssKttAAH
0	10		S188-p	GLGRFFssKttAAHs
0	1		K189	LGRFFssKttAAHsL
0	4		T190-p	GRFFssKttAAHsLV
0	3		T191-p	RFFssKttAAHsLVG
0	64		S195-p	sKttAAHsLVGtPyY
0	6		T199-p	AAHsLVGtPyYMSPE
0	9		Y201-p	HsLVGtPyYMSPERI
0	118		Y244-p	YGDKMNLySLCKKIE
0	1		T286-p	PEKRPDVtyVyDVAk
0	2		Y287-p	EKRPDVtyVyDVAkR
0	4		Y289-p	RPDVtyVyDVAkRMH
0	1		K293-u	tyVyDVAkRMHACTA

	mouse
S5	___MDEQSQGMQGPP
T30	RPDMGYNTLANFRIE
K74-u	IFDLMDAkARADCIK
Y97	NHPNVIKYYASFIED
S147	KYFVQLCSALDHMHS
S187	LGLGRFFSskttAAH
S188-p	GLGRFFSskttAAHs
K189-u	LGRFFSskttAAHsL
T190-p	GRFFSskttAAHsLV
T191-p	RFFSskttAAHsLVG
S195-p	skttAAHsLVGTPYY
T199	AAHsLVGTPYYMSPE
Y201	HsLVGTPYYMSPERI
Y244	YGDKMNLYSLCKKIE
A286	PEKRPDIAYVYDVAK
Y287	EKRPDIAYVYDVAKR
Y289	RPDIAYVYDVAKRMH
K293	AYVYDVAKRMHACTA

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