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Protein Page:
NEK7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NEK7 a protein kinase of the NEK family. Phosphorylates and activates p70S6 kinase. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Other group; NEK family
Cellular Component: spindle pole; microtubule; cytoplasm; microtubule organizing center; nucleus
Molecular Function: protein serine/threonine kinase activity; metal ion binding; ATP binding
Biological Process: regulation of mitotic cell cycle; cytokinesis; spindle assembly; protein amino acid phosphorylation
Reference #:  Q8TDX7 (UniProtKB)
Alt. Names/Synonyms: NEK7; Never in mitosis A-related kinase 7; NIMA (never in mitosis gene a)-related kinase 7; NimA-related protein kinase 7; Serine/threonine-protein kinase Nek7
Gene Symbols: NEK7
Molecular weight: 34,551 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NEK7

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y97‑p
enzymatic activity, inhibited: Y97‑p
protein conformation: Y97‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S5-p ___MDEQsQGMQGPP
0 1 T30-p RPDMGYNtLANFRIE
0 1 K74 IFDLMDAKARADCIK
1 0 Y97-p NHPNVIKyYASFIED
0 1 S147-p KYFVQLCsALEHMHS
0 4 S187-p LGLGRFFssKttAAH
0 11 S188-p GLGRFFssKttAAHs
0 1 K189 LGRFFssKttAAHsL
0 5 T190-p GRFFssKttAAHsLV
0 5 T191-p RFFssKttAAHsLVG
0 66 S195-p sKttAAHsLVGtPYY
0 6 T199-p AAHsLVGtPYYMSPE
0 116 Y244-p YGDKMNLySLCKKIE
0 1 T286-p PEKRPDVtyVyDVAk
0 2 Y287-p EKRPDVtyVyDVAkR
0 4 Y289-p RPDVtyVyDVAkRMH
0 1 K293-ub tyVyDVAkRMHACTA
  mouse

 
S5 ___MDEQSQGMQGPP
T30 RPDMGYNTLANFRIE
K74-ub IFDLMDAkARADCIK
Y97 NHPNVIKYYASFIED
S147 KYFVQLCSALDHMHS
S187 LGLGRFFSskttAAH
S188-p GLGRFFSskttAAHs
K189-ub LGRFFSskttAAHsL
T190-p GRFFSskttAAHsLV
T191-p RFFSskttAAHsLVG
S195-p skttAAHsLVGTPYY
T199 AAHsLVGTPYYMSPE
Y244 YGDKMNLYSLCKKIE
A286 PEKRPDIAYVYDVAK
Y287 EKRPDIAYVYDVAKR
Y289 RPDIAYVYDVAKRMH
K293 AYVYDVAKRMHACTA
  rat

 
P5 ___MDEQPQGMQGPP
T30 RPDMGYNTLANFRIE
K74 IFDLMDAKARADCIK
Y97 NHPNVIKYYASFIED
S147 KYFVQLCSALDHMHS
S187 LGLGRFFSSKTTAAH
S188 GLGRFFSSKTTAAHS
K189 LGRFFSSKTTAAHSL
T190 GRFFSSKTTAAHSLV
T191 RFFSSKTTAAHSLVG
S195 SKTTAAHSLVGTPYY
T199 AAHSLVGTPYYMSPE
Y244 YGDKMNLYSLCKKIE
A286 PEKRPDIAYVYDVAK
Y287 EKRPDIAYVYDVAKR
Y289 RPDIAYVYDVAKRMH
K293 AYVYDVAKRMHACTA
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