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Protein Page:
ATPIF1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATPIF1 Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Homodimer at a pH value below 6.5, inactive homotetramer above. Belongs to the ATPase inhibitor family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Inhibitor protein
Cellular Component: cell surface; mitochondrion; mitochondrial proton-transporting ATP synthase complex
Molecular Function: calmodulin binding; enzyme inhibitor activity; angiostatin binding; protein homodimerization activity; ATPase inhibitor activity; ATPase binding
Biological Process: generation of precursor metabolites and energy; negative regulation of hydrolase activity; negative regulation of endothelial cell proliferation; erythrocyte differentiation; angiogenesis; protein homooligomerization; negative regulation of nucleotide metabolic process; heme biosynthetic process; protein homotetramerization
Reference #:  Q9UII2 (UniProtKB)
Alt. Names/Synonyms: ATIF1; ATP synthase inhibitor protein; ATPase inhibitor protein; ATPase inhibitor, mitochondrial; ATPase inhibitory factor 1; ATPI; ATPIF1; ATPIP; IF(1); IF1; Inhibitor of F(1)F(o)-ATPase; IP; MGC1167; MGC8898
Gene Symbols: ATPIF1
Molecular weight: 12,249 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATPIF1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S27-p MQARGFGsDQSENVD
0 1 N32 FGsDQSENVDRGAGs
0 3 S39-p NVDRGAGsIREAGGA
0 2 K49 EAGGAFGKREQAEEE
0 1 K49-sc EAGGAFGkREQAEEE
0 3 Y58-p EQAEEERyFRAQsRE
0 2 S63-p ERyFRAQsREQLAAL
0 1 R64 RyFRAQsREQLAALk
0 3 K71-ac REQLAALkKHHEEEI
0 84 K82-ac EEEIVHHkkEIERLQ
0 1 K82-sc EEEIVHHkkEIERLQ
0 19 K83-ac EEIVHHkkEIERLQk
0 1 K90 kEIERLQKEIERHKQ
0 1 K90-sc kEIERLQkEIERHKQ
0 1 K103 KQKIKMLKHDD____
  mouse

 
S27 LQTRGFVSDSSDsMD
S32-p FVSDSSDsMDTGAGS
S39 sMDTGAGSIREAGGA
K49-ac EAGGAFGkREKAEED
K49 EAGGAFGKREKAEED
Y58 EKAEEDRYFREKTkE
T63 DRYFREKTkEQLAAL
K64-ub RYFREKTkEQLAALR
R71 kEQLAALRKHHEDEI
S82 EDEIDHHSKEIERLQ
S82 EDEIDHHSKEIERLQ
K83 DEIDHHSKEIERLQk
K90-ac KEIERLQkQIERHKK
K90 KEIERLQKQIERHKK
K103-ac KKKIQQLkNNH____
  rat

 
S27 LQTRGFGSDSSESMD
S32 FGSDSSESMDSGAGS
S39 SMDSGAGSIREAGGA
K49 EAGGAFGKREKAEED
K49 EAGGAFGKREKAEED
Y58 EKAEEDRYFREKTRE
T63 DRYFREKTREQLAAL
R64 RYFREKTREQLAALK
K71 REQLAALKKHHEDEI
S82 EDEIDHHSKEIERLQ
S82 EDEIDHHSKEIERLQ
K83 DEIDHHSKEIERLQK
K90 KEIERLQKQIERHKK
K90 KEIERLQKQIERHKK
K103 KKKIKYLKNSEH___
  cow

 
S27 MQGRGFGSESGDNVR
N32 FGSESGDNVRSSAGA
A39 NVRSSAGAVRDAGGA
K49 DAGGAFGKREQAEEE
K49 DAGGAFGKREQAEEE
Y58 EQAEEERYFRARAKE
A63 ERYFRARAKEQLAAL
K64 RYFRARAKEQLAALK
K71 KEQLAALKKHHENEI
A82 ENEISHHAKEIERLQ
A82 ENEISHHAKEIERLQ
K83 NEISHHAKEIERLQK
K90 KEIERLQKEIERHKQ
K90 KEIERLQKEIERHKQ
K103 KQSIKKLKQSEDDD_
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