Home

ATPIF1 (human)

Overview ATPIF1 Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Homodimer at a pH value below 6.5, inactive homotetramer above. Belongs to the ATPase inhibitor family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Inhibitor protein; Mitochondrial Cellular Component: cell surface; mitochondrion; mitochondrial proton-transporting ATP synthase complex Molecular Function: calmodulin binding; enzyme inhibitor activity; angiostatin binding; protein homodimerization activity; ATPase inhibitor activity; ATPase binding Biological Process: regulation of apoptosis; generation of precursor metabolites and energy; negative regulation of hydrolase activity; negative regulation of endothelial cell proliferation; angiogenesis; negative regulation of nucleotide metabolic process; protein homooligomerization; protein homotetramerization Reference #:  Q9UII2 (UniProtKB) Alt. Names/Synonyms: ATIF1; ATP synthase inhibitor protein; ATPase inhibitor protein; ATPase inhibitor, mitochondrial; ATPase inhibitory factor 1; ATPI; ATPIF1; ATPIP; IF(1); IF1; Inhibitor of F(1)F(o)-ATPase; IP; MGC1167; MGC8898 Gene Symbols: ATPIF1 Molecular weight: 12,249 Da Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATPIF1 1GMJ - A/B/C/D=26-109 (cow) 1HF9 - A/B=69-109 (cow) 1OHH - H=26-109 (cow) 2V7Q - H=23-168 (cow)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S27-p	MQARGFGsDQSENVD
0	1		N32	FGsDQSENVDRGAGs
0	1		S39-p	NVDRGAGsIREAGGA
0	2		K49-a	EAGGAFGkREQAEEE
0	3		Y58-p	EQAEEERyFRAQsRE
0	1		S63-p	ERyFRAQsREQLAAL
0	1		R64	RyFRAQsREQLAALk
0	3		K71-a	REQLAALkKHHEEEI
0	83		K82-a	EEEIVHHkkEIERLQ
0	19		K83-a	EEIVHHkkEIERLQK
0	1		K90	kEIERLQKEIERHKQ
0	1		K103	KQKIKMLKHDD____

	mouse
S27	LQTRGFVSDSSDsMD
S32-p	FVSDSSDsMDTGAGS
S39	sMDTGAGSIREAGGA
K49-a	EAGGAFGkREKAEED
Y58	EKAEEDRYFREKTkE
T63	DRYFREKTkEQLAAL
K64-u	RYFREKTkEQLAALR
R71	kEQLAALRKHHEDEI
S82	EDEIDHHSKEIERLQ
K83	DEIDHHSKEIERLQk
K90-a	KEIERLQkQIERHKK
K103-a	KKKIQQLkNNH____

	rat
S27	LQTRGFGSDSSESMD
S32	FGSDSSESMDSGAGS
S39	SMDSGAGSIREAGGA
K49	EAGGAFGKREKAEED
Y58	EKAEEDRYFREKTRE
T63	DRYFREKTREQLAAL
R64	RYFREKTREQLAALK
K71	REQLAALKKHHEDEI
S82	EDEIDHHSKEIERLQ
K83	DEIDHHSKEIERLQK
K90	KEIERLQKQIERHKK
K103	KKKIKYLKNSEH___

	cow
S27	MQGRGFGSESGDNVR
N32	FGSESGDNVRSSAGA
A39	NVRSSAGAVRDAGGA
K49	DAGGAFGKREQAEEE
Y58	EQAEEERYFRARAKE
A63	ERYFRARAKEQLAAL
K64	RYFRARAKEQLAALK
K71	KEQLAALKKHHENEI
A82	ENEISHHAKEIERLQ
K83	NEISHHAKEIERLQK
K90	KEIERLQKEIERHKQ
K103	KQSIKKLKQSEDDD_

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.