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Protein Page:
TH1L (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TH1L Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is composed of 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform NELF-C or isoform NELF-D) and RDBP/NELF-E. Interacts with ARAF1. Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas. Belongs to the NELF-D family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: nucleoplasm
Molecular Function: protein binding
Biological Process: transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression; negative regulation of transcription, DNA-dependent
Reference #:  Q8IXH7 (UniProtKB)
Alt. Names/Synonyms: HSPC130; Negative elongation factor C/D; negative elongation factor proteins C and D; NELF-C; NELF-C/D; NELF-D; NELFD; TH1; TH1 drosophila homolog; TH1-like (Drosophila); TH1-like protein; TH1L; trihydrophobin 1
Gene Symbols: TH1L
Molecular weight: 66,247 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TH1L

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 Y15 AIMDEDYYGSAAEWG
0 2 K67-u PSIFNTLkRYFQAGG
0 1 K125-u HLKSLLIkHFDPRKA
  TH1L iso4  
Y6-p __MDEDYyGSAAEWG
K58 PSIFNTLKRYFQAGG
K116 HLKSLLIKHFDPRKA
  mouse

 
F15 TIMGEDYFGNASEWG
K68 PSIFNTLKRYFQAGG
K126 HLKSLLIKHFDPRKA
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