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Protein Page:
NELFCD (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NELFCD Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is composed of 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform NELF-C or isoform NELF-D) and RDBP/NELF-E. Interacts with ARAF1. Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas. Belongs to the NELF-D family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: nucleoplasm; membrane
Molecular Function: protein binding
Biological Process: transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression; negative regulation of transcription, DNA-dependent
Reference #:  Q8IXH7 (UniProtKB)
Alt. Names/Synonyms: HSPC130; Negative elongation factor C/D; negative elongation factor proteins C and D; NELF-C; NELF-C/D; NELF-D; NELFCD; NELFD; TH1; TH1 drosophila homolog; TH1-like (Drosophila); TH1-like protein; TH1L; trihydrophobin 1
Gene Symbols: NELFCD
Molecular weight: 66,247 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NELFCD

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 Y15 AIMDEDYYGSAAEWG
0 1 S34-p GGQQEDDsGEGEDDA
0 2 K67-ub PSIFNTLkRYFQAGG
0 1 S121-p TVENHLKsLLIkHFD
0 1 K125-ub HLKsLLIkHFDPRKA
0 2 T280-p GHDASQItLALGtAA
0 1 T285-p QItLALGtAASyPRA
0 1 Y289-p ALGtAASyPRACQAL
0 1 S301-p QALGAMLsKGALNPA
0 1 K372-ac SVVETWKkNkRVSIN
0 1 K374-ac VETWKkNkRVSINkD
0 1 K380-ac NkRVSINkDELKSTS
  NELFCD iso4  
Y6-p __MDEDYyGSAAEWG
S25 GGQQEDDSGEGEDDA
K58 PSIFNTLKRYFQAGG
S112 TVENHLKSLLIKHFD
K116 HLKSLLIKHFDPRKA
T271 GHDASQITLALGTAA
T276 QITLALGTAASYPRA
Y280 ALGTAASYPRACQAL
S292 QALGAMLSKGALNPA
K363 SVVETWKKNKRVSIN
K365 VETWKKNKRVSINKD
K371 NKRVSINKDELKSTS
  mouse

 
F15 TIMGEDYFGNASEWG
S35 GQHQEDDSGEGEDDA
K68 PSIFNTLKRYFQAGG
S122 TVENHLKSLLIKHFD
K126 HLKSLLIKHFDPRKA
T281 GHDASQITLALGTAA
T286 QITLALGTAASYPRA
Y290 ALGTAASYPRACQAL
S302 QALGAMLSRGALNPA
K373 SVVETWKKNKRVSIG
K375 VETWKKNKRVSIGKD
K381 NKRVSIGKDELKSTS
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