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Protein Page:
RNASEH2B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RNASEH2B Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. Belongs to the RNase H2 subunit B family. Note: This description may include information from UniProtKB.
Protein type: DNA replication; RNA processing
Cellular Component: nucleolus; nucleus
Molecular Function: ribonuclease H activity
Biological Process: positive regulation of fibroblast proliferation; ribonucleotide metabolic process; in utero embryonic development; regulation of G2/M transition of mitotic cell cycle; RNA catabolic process
Reference #:  Q5TBB1 (UniProtKB)
Alt. Names/Synonyms: AGS2; Aicardi-Goutieres syndrome 2 protein; deleted in leukemia 8 protein; Deleted in lymphocytic leukemia 8; DLEU8; FLJ11712; Ribonuclease H2 subunit B; ribonuclease H2, subunit B; Ribonuclease HI subunit B; RNase H2 subunit B; RNASEH2B; RNH2B
Gene Symbols: RNASEH2B
Molecular weight: 35,139 Da
Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states
Select Structure to View Below

RNASEH2B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 N33 DASKKMKNGLMFVKL
0 2 G34 ASKKMKNGLMFVKLV
0 1 T174-p LEKKVNQtVAALKTN
0 2 S191-p NVSSRVQsTAFFSGD
0 1 K230-ub ELSDDLSkYLKLPEP
0 1 S240-p KLPEPSAsLPNPPSk
0 3 K247-ac sLPNPPSkKIKLSDE
0 9 Y262-p PVEAKEDytkFNtKD
0 2 T263-p VEAKEDytkFNtKDL
0 1 K264-ac EAKEDytkFNtKDLK
0 2 T267-p EDytkFNtKDLKTEK
0 1 K295-ac KVDKSGMksIDtFFG
0 1 S296-p VDKSGMksIDtFFGV
0 2 T299-p SGMksIDtFFGVKNK
  mouse

 
S33-p ASKKKKKssLLFVKL
S34-p SKKKKKssLLFVKLA
T171 LEKKVNQTVVALKAN
S188 NVGARVQSSAYFSGG
K227 ELSDDLSKFLKLPEP
S237 KLPEPPASLTNPPSK
K244 SLTNPPSKKLKLSDE
Y259 PVEAKEDYTKFNTKD
T260 VEAKEDYTKFNTKDL
K261 EAKEDYTKFNTKDLK
T264 EDYTKFNTKDLKTGK
K292 KVDKSGMKSIDAFFG
S293 VDKSGMKSIDAFFGA
A296 SGMKSIDAFFGAKNK
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