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PANK4 (human)

Overview PANK4 a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK4 is ubiquitously expressed but is enriched in muscle. Plays a role in the physiological regulation of the intracellular CoA concentration. Regulated by feedback inhibition by CoA and its thioesters. Interacts with M2-type pyruvate kinase (PKM2) and may modulate glucose metabolism through regulating the activity of PKM2. Expression is up-regulated by high glucose concentrations. Note: This description may include information from UniProtKB. Protein type: EC 2.7.1.33; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Kinase, other Cellular Component: cytoplasm Molecular Function: pantothenate kinase activity; ATP binding Biological Process: coenzyme A biosynthetic process Reference #:  Q9NVE7 (UniProtKB) Alt. Names/Synonyms: DKFZp547M242; FLJ10782; hPanK4; PANK4; Pantothenate kinase 4; Pantothenic acid kinase 4 Gene Symbols: PANK4 Molecular weight: 85,991 Da Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PANK4

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y51-p	SLTKLAYySTVQHKV
0	2		S63-p	HKVAKVRsFDHSGKD
0	1		K118-u	HLVNTETkVIQAtGG
0	1		T123-p	ETkVIQAtGGGAYkF
0	1		K129-u	AtGGGAYkFKDLIEE
0	2		K137-u	FKDLIEEkLRLKVDK
0	2		K171-u	HEAFVYQkDSDPEFR
0	2		K234-u	ALLTKTKkFDELLHL
0	1		K278-u	LIASSFGksATADQE
0	1		S279-p	IASSFGksATADQEF
0	1		K288-u	TADQEFSkEDMAKSL
0	1		S391	AGSSGLMSASPELGP
0	34		S404-p	GPAQRARsGtFDLLE
0	62		T406-p	AQRARsGtFDLLEMD
0	2		K487-u	FRQKYWNkLQTLRQQ
0	1		K559-u	ERQLALVkGLLAGNV
0	2		K590-u	YFGFEEAkRKLQERP

	mouse
Y51	SLTKLAYYSTVQHKV
S63	HKVAKVRSFDHPGKD
K118	HLVNTETKVIQATGG
T123	ETKVIQATGGGAYKF
K129	ATGGGAYKFKDLIEE
K137-u	FKDLIEEkLRLKVDK
K171-u	HEAFMYQkDSDPEFR
K234-u	ALLTKTKkFDELLQL
K278	LIASSFGKSATADRE
S279	IASSFGKSATADREF
K288	TADREFSKEDMAKSL
S391-p	AASSGLMsTSPELCP
S404-p	CPTQRARsGtFDLLE
T406-p	TQRARsGtFDLLEMD
K487-u	FRQKYWGkLQTLRHQ
K559	ERQLALVKGLLAGNV
K590-u	QFGFEEAkRKLQERP

	rat
Y51	SLTKLAYYSTVQHKV
S63	HKVAKVRSFDHPGKD
K118	HLVNTETKVIQATGG
T123	ETKVIQATGGGAYKF
K129	ATGGGAYKFKDLIEE
K137	FKDLIEEKLRLKVDK
K171	HEAFMYQKDSDPEFR
K234	ALLTKTKKFDELLQL
K278	LIASSFGKSATADRE
S279	IASSFGKSATADREF
K288	TADREFSKEDMAKSL
S391	AASSGLMSTAPELCP
S404	CPTQRARSGTFDLLE
T406	TQRARSGTFDLLEMD
K487	FRQKYWGKLQTLRHQ
K559	ERQLALVKGLLAGNV
K590	QFGFEEAKRKLQERP

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