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Protein Page:
PANK4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PANK4 a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK4 is ubiquitously expressed but is enriched in muscle. Plays a role in the physiological regulation of the intracellular CoA concentration. Regulated by feedback inhibition by CoA and its thioesters. Interacts with M2-type pyruvate kinase (PKM2) and may modulate glucose metabolism through regulating the activity of PKM2. Expression is up-regulated by high glucose concentrations. Note: This description may include information from UniProtKB.
Protein type: Kinase, other; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.7.1.33
Chromosomal Location of Human Ortholog: 1p36.32
Cellular Component: cytoplasm
Molecular Function: pantothenate kinase activity; ATP binding
Biological Process: coenzyme A biosynthetic process; phosphorylation
Reference #:  Q9NVE7 (UniProtKB)
Alt. Names/Synonyms: DKFZp547M242; FLJ10782; hPanK4; PANK4; Pantothenate kinase 4; Pantothenic acid kinase 4
Gene Symbols: PANK4
Molecular weight: 85,991 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PANK4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S19-p SGDSLDKsITLPPDE
0 2 Y51-p SLTKLAYySTVQHKV
0 2 S63-p HKVAKVRsFDHSGKD
0 1 K118-ub HLVNTETkVIQAtGG
0 1 T123-p ETkVIQAtGGGAYkF
0 1 K129-ub AtGGGAYkFKDLIEE
0 2 K137-ub FKDLIEEkLRLKVDK
0 2 K171-ub HEAFVYQkDSDPEFR
0 2 K234-ub ALLTKTKkFDELLHL
0 1 K278-ub LIASSFGksATADQE
0 1 S279-p IASSFGksATADQEF
0 1 K288-ub TADQEFSkEDMAKSL
0 1 S391-p AGSSGLMsAsPELGP
0 2 S393-p SSGLMsAsPELGPAQ
0 35 S404-p GPAQRARsGtFDLLE
0 62 T406-p AQRARsGtFDLLEMD
0 2 K487-ub FRQKYWNkLQTLRQQ
0 1 K559-ub ERQLALVkGLLAGNV
0 2 K590-ub YFGFEEAkRKLQERP
  mouse

 
S19 GGDSLDKSITLPPDE
Y51 SLTKLAYYSTVQHKV
S63 HKVAKVRSFDHPGKD
K118 HLVNTETKVIQATGG
T123 ETKVIQATGGGAYKF
K129 ATGGGAYKFKDLIEE
K137-ub FKDLIEEkLRLKVDK
K171-ub HEAFMYQkDSDPEFR
K234-ub ALLTKTKkFDELLQL
K278 LIASSFGKSATADRE
S279 IASSFGKSATADREF
K288 TADREFSKEDMAKSL
S391-p AASSGLMsTSPELCP
S393 SSGLMsTSPELCPTQ
S404-p CPTQRARsGtFDLLE
T406-p TQRARsGtFDLLEMD
K487-ub FRQKYWGkLQTLRHQ
K559 ERQLALVKGLLAGNV
K590-ub QFGFEEAkRKLQERP
  rat

 
S19 GGDSLDKSITLPPDE
Y51 SLTKLAYYSTVQHKV
S63 HKVAKVRSFDHPGKD
K118 HLVNTETKVIQATGG
T123 ETKVIQATGGGAYKF
K129 ATGGGAYKFKDLIEE
K137 FKDLIEEKLRLKVDK
K171 HEAFMYQKDSDPEFR
K234 ALLTKTKKFDELLQL
K278 LIASSFGKSATADRE
S279 IASSFGKSATADREF
K288 TADREFSKEDMAKSL
S391 AASSGLMSTAPELCP
A393 SSGLMSTAPELCPTQ
S404 CPTQRARSGtFDLLE
T406-p TQRARSGtFDLLEMD
K487 FRQKYWGKLQTLRHQ
K559 ERQLALVKGLLAGNV
K590 QFGFEEAKRKLQERP
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