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Protein Page:
LIN28B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LIN28B Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Interacts with ZCCHC11/TUT4. Might be negatively regulated by the microRNA let-7b. High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta. Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues. Belongs to the lin-28 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding; RNA binding
Biological Process: regulation of transcription, DNA-dependent; pre-microRNA processing; RNA 3'-end processing
Reference #:  Q6ZN17 (UniProtKB)
Alt. Names/Synonyms: CSDD2; FLJ16517; lin-28 homolog B (C. elegans); Lin-28.2; Lin-28B; LIN28B; LN28B; Protein lin-28 homolog B
Gene Symbols: LIN28B
Molecular weight: 27,084 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LIN28B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S54-p SMINREGsPLDIPVD
0 2 S96-p KSSKGLEsIRVTGPG
0 3 S105-p RVTGPGGsPCLGsER
0 1 S110-p GGsPCLGsERRPKGK
0 2 S203-p GGGHGCTsPPFPQEA
0 1 S218-p RAEISERsGRsPQEA
0 3 S221-p ISERsGRsPQEASST
0 3 K240-ac APEEQSKkGPSVQKR
  mouse

 
N52 SMISREGNPLDIPVD
S94 KSPKGLESIRVTGPG
S103 RVTGPGGSPCLGSER
S108 GGSPCLGSERRPKGK
- gap
S215 KSEMAEHSDRsPQEV
S218-p MAEHSDRsPQEVSST
K237 AIGEQNKKGPLIQKR
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