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MYPT1 (human)

Overview MYPT1 myosin phosphatase target subunit 1, a regulatory subunit of protein phosphatase 1. Also called the myosin-binding subunit of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. Four splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Cellular Component: kinetochore; centrosome; contractile fiber Molecular Function: enzyme inhibitor activity; signal transducer activity; protein binding; phosphatase regulator activity; protein kinase binding; phosphoprotein phosphatase activity Biological Process: regulation of cell adhesion; mitosis; centrosome organization and biogenesis; regulation of nucleocytoplasmic transport; negative regulation of catalytic activity; positive regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; signal transduction Reference #:  O14974 (UniProtKB) Alt. Names/Synonyms: MBS; MGC133042; Myosin phosphatase target subunit 1; myosin phosphatase, target subunit 1; Myosin phosphatase-targeting subunit 1; MYPT1; PPP1R12A; Protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; Protein phosphatase myosin-binding subunit Gene Symbols: PPP1R12A Molecular weight: 115,281 Da Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MYPT1 2KJY - A=658-714 (human)

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	Sites Implicated In
cell adhesion, altered: S445‑p, S472‑p, S910‑p intracellular localization: T696‑p molecular association, regulation: S445‑p, S472‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K9-a	KMADAKQkRNEQLKR
1	0		S20-p	QLKRWIGsEtDLEPP
1	0		T22-p	KRWIGsEtDLEPPVV
0	1		Y68-p	HRGADINyANVDGLT
0	15		K285-u	GYLEELQkkQNLLHS
0	3		K286-u	YLEELQkkQNLLHSE
1	31		S299-p	SEKRDKKsPLIEsTA
1	1		S304-p	KKsPLIEsTANMDNN
0	1		S313-p	ANMDNNQsQKTFKNK
0	1		K320	sQKTFKNKETLIIEP
0	1		S353	EEGKKDESSCSSEED
0	1		S354	EGKKDESSCSSEEDE
0	1		S367	DEEDDSESEAETDKT
0	1		T371	DSESEAETDKTKPLA
0	1		T381	TKPLASVTNANTSST
0	1		T406-p	TVSSGQAtPTsPIKK
0	8		S409-p	SGQAtPTsPIKKFPT
0	1		T417-p	PIKKFPTtAtKIsPK
0	2		T419-p	KKFPTtAtKIsPKEE
1	12		S422-p	PTtAtKIsPKEEERK
1	1		S432-p	EEERKDEsPATWRLG
0	1		K442-a	TWRLGLRktGsyGAL
1	19		T443-p	WRLGLRktGsyGALA
2	85		S445-p	LGLRktGsyGALAEI
0	67		Y446-p	GLRktGsyGALAEIt
1	2		T453-p	yGALAEItASkEGQk
0	1		K456-a	LAEItASkEGQkEKD
0	1		K460-a	tASkEGQkEKDtAGV
0	3		T464-p	EGQkEKDtAGVTRsA
0	4		S470-p	DtAGVTRsAssPRLs
1	42		S472-p	AGVTRsAssPRLsss
2	9		S473-p	GVTRsAssPRLsssL
1	3		S477-p	sAssPRLsssLDNKE
1	1		S478-p	AssPRLsssLDNKEK
0	2		S479-p	ssPRLsssLDNKEKE
0	460		Y496-p	SKGTRLAyVAPtIPR
0	6		A498	GTRLAyVAPtIPRRL
1	22		T500-p	RLAyVAPtIPRRLAs
1	769		S507-p	tIPRRLAstsDIEEK
1	134		T508-p	IPRRLAstsDIEEKE
1	242		S509-p	PRRLAstsDIEEKEN
0	1		S520-p	EKENRDSssLRTsSS
0	3		S521-p	KENRDSssLRTsSSY
0	2		S525-p	DSssLRTsSSYtRRK
0	1		S526	SssLRTsSSYtRRKW
0	1		S527	ssLRTsSSYtRRKWE
0	2		T529-p	LRTsSSYtRRKWEDD
0	2		S541-p	EDDLKKNssVNEGst
0	2		S542-p	DDLKKNssVNEGsty
0	5		S547-p	NssVNEGstyHKsCs
0	14		T548-p	ssVNEGstyHKsCsF
0	71		Y549-p	sVNEGstyHKsCsFG
0	1		S552-p	EGstyHKsCsFGRRQ
0	4		S554-p	styHKsCsFGRRQDD
0	1		T571-p	SSSVPSTtStPtVTs
0	1		T573-p	SVPSTtStPtVTsAA
0	1		T575-p	PSTtStPtVTsAAGL
0	1		S578-p	tStPtVTsAAGLQKS
0	1		S591	KSLLSSTSTTTKITT
0	3		I596	STSTTTKITTGSSSA
1	0		S601	TKITTGSSSAGTQsS
0	1		S607-p	SSSAGTQsSTSNRLW
0	1		S618	NRLWAEDSTEKEKDS
0	1		T619	RLWAEDSTEKEKDSV
0	1		T631-p	DSVPTAVtIPVAPTV
0	1		T645-p	VVNAAAStTtLTTTt
0	1		T647-p	NAAAStTtLTTTtAG
0	1		T652-p	tTtLTTTtAGTVSST
3	142		S668-p	EVRERRRsyLtPVRD
0	24		Y669-p	VRERRRsyLtPVRDE
1	12		T671-p	ERRRsyLtPVRDEEs
1	2		S678-p	tPVRDEEsEsQRKAR
1	0		S680-p	VRDEEsEsQRKARSR
0	9		S692-p	RSRQARQsRRstQGV
9	46		S695-p	QARQsRRstQGVtLt
49	223		T696-p	ARQsRRstQGVtLtD
0	1		T700-p	RRstQGVtLtDLQEA
0	4		T702-p	stQGVtLtDLQEAEK
1	1		T710-p	DLQEAEKtIGRSRst
0	6		S716-p	KtIGRSRstRTREQE
1	4		T717-p	tIGRSRstRTREQEN
0	1		K743-a	DKEKQEEkKESEtsR
0	1		T748-p	EEkKESEtsREDEyk
0	1		S749-p	EkKESEtsREDEykQ
0	3		Y754-p	EtsREDEykQKysRt
0	1		K755-a	tsREDEykQKysRty
0	7		Y758-p	EDEykQKysRtyDEt
0	2		S759-p	DEykQKysRtyDEty
0	18		T761-p	ykQKysRtyDEtyQR
0	233		Y762-p	kQKysRtyDEtyQRY
0	48		T765-p	ysRtyDEtyQRYRPV
0	430		Y766-p	sRtyDEtyQRYRPVS
0	1		Y769	yDEtyQRYRPVSTSS
0	1		S781-p	TSSSTTPsSSLSTMS
0	8		S790-p	SLSTMSSsLyAssQL
0	20		Y792-p	STMSSsLyAssQLNR
0	1		S794-p	MSSsLyAssQLNRPN
0	4		S795-p	SSsLyAssQLNRPNs
0	43		S802-p	sQLNRPNsLVGITSA
0	29		Y810-p	LVGITSAysRGITKE
0	1		S811-p	VGITSAysRGITKEN
0	1		K816	AysRGITKENEREGE
0	1		S835	EKEGEDKSQPKsIRE
0	3		S839-p	EDKSQPKsIRERRRP
7	15		S852-p	RPREKRRstGVsFWt
28	17		T853-p	PREKRRstGVsFWtQ
0	1		S856-p	KRRstGVsFWtQDsD
0	3		T859-p	stGVsFWtQDsDENE
0	22		S862-p	VsFWtQDsDENEQEQ
1	38		S871-p	ENEQEQQsDtEEGsN
0	3		T873-p	EQEQQsDtEEGsNKK
0	2		S877-p	QsDtEEGsNKKETQt
0	4		T884-p	sNKKETQtDsIsRyE
0	2		S886-p	KKETQtDsIsRyEts
0	1		S888-p	ETQtDsIsRyEtssT
0	78		Y890-p	QtDsIsRyEtssTsA
0	9		T892-p	DsIsRyEtssTsAGD
0	3		S893-p	sIsRyEtssTsAGDR
0	1		S894-p	IsRyEtssTsAGDRy
0	4		S896-p	RyEtssTsAGDRyDs
0	115		Y901-p	sTsAGDRyDsLLGRs
0	33		S903-p	sAGDRyDsLLGRsGs
0	11		S908-p	yDsLLGRsGsysyLE
2	70		S910-p	sLLGRsGsysyLEER
0	339		Y911-p	LLGRsGsysyLEERK
0	13		S912-p	LGRsGsysyLEERKP
0	77		Y913-p	GRsGsysyLEERKPy
0	7		Y920-p	yLEERKPyssRLEKD
0	1		S921-p	LEERKPyssRLEKDD
0	1		S922-p	EERKPyssRLEKDDS
0	1		Y936-p	STDFKKLyEQILAEN
1	38		S995-p	RALERRIsEMEEELk
0	1		K1002-m2	sEMEEELkMLPDLkA
0	1		K1008-m2	LkMLPDLkADNQRLK

	mouse
K9	KMADAKQKRNEQLKR
S20	QLKRWIGSETDLEPP
T22	KRWIGSETDLEPPVV
Y68	HRGADINYANVDGLT
K285-u	GYLEELQkkQTLLHS
K286-u	YLEELQkkQTLLHSE
S299-p	SEKRDKKsPLIESTA
S304	KKsPLIESTANMENN
P313	ANMENNQPQKAFKNk
K320-u	PQKAFKNkETLIIEP
S353-p	EEGKKDEssCSSEED
S354-p	EGKKDEssCSSEEDE
S367-p	DEEDDSEsEAEtDKT
T371-p	DSEsEAEtDKTKPMA
S381-gl	TKPMASVsNAHTSST
T406	TLSSNQGTPTSPVKK
S409	SNQGTPTSPVKKFPI
S417	PVKKFPISTTKIsPK
T419	KKFPISTTKIsPKEE
S422-p	PISTTKIsPKEEERK
S432	EEERKDESPASWRLG
K442	SWRLGLRKtGsyGAL
T443-p	WRLGLRKtGsyGALA
S445-p	LGLRKtGsyGALAEI
Y446-p	GLRKtGsyGALAEIS
S453	yGALAEISASKEAQK
K456	LAEISASKEAQKEKD
K460	SASKEAQKEKDtAGV
T464-p	EAQKEKDtAGVMRSA
S470	DtAGVMRSAssPRLS
S472-p	AGVMRSAssPRLSSS
S473-p	GVMRSAssPRLSSSL
S477	SAssPRLSSSLDNKE
S478	AssPRLSSSLDNKEK
S479	ssPRLSSSLDNKEKE
Y496-p	NKGTRLAyVtPTIPR
T498-p	GTRLAyVtPTIPRRL
T500	RLAyVtPTIPRRLAs
S507-p	TIPRRLAstsDIEEK
T508-p	IPRRLAstsDIEEKE
S509-p	PRRLAstsDIEEKEN
S520	EKENRESSsLRTsss
S521-p	KENRESSsLRTsssY
S525-p	ESSsLRTsssYTRRK
S526-p	SSsLRTsssYTRRKW
S527-p	SsLRTsssYTRRKWE
T529	LRTsssYTRRKWEDD
S541	EDDLKKNSSINEGST
S542	DDLKKNSSINEGSTy
S547	NSSINEGSTyHRSCs
T548	SSINEGSTyHRSCsF
Y549-p	SINEGSTyHRSCsFG
S552	EGSTyHRSCsFGRRQ
S554-p	STyHRSCsFGRRQDD
T571	SCSVPSTTSTPTVTS
T573	SVPSTTSTPTVTSAA
T575	PSTTSTPTVTSAAGL
S578	TSTPTVTSAAGLQRS
S591-p	RSLPSSTsTAAKtPP
T596-p	STsTAAKtPPGSSSA
S601	AKtPPGSSSAGTQSS
S607	SSSAGTQSSTSNRLW
S618-p	NRLWAEDstEKEKDS
T619-p	RLWAEDstEKEKDSA
T631	DSAPTAVTIPVAPTV
T646	VNAAAPSTTTLTTTT
T648	AAAPSTTTLTTTTAG
T653	TTTLTTTTAGTVSEV
S666-p	EVRERRRsyLTPVRD
Y667-p	VRERRRsyLTPVRDE
T669	ERRRsyLTPVRDEES
S676	TPVRDEESESQRKAR
S678	VRDEESESQRKARSR
S690	RSRQARQSRRstQGV
S693-p	QARQSRRstQGVTLT
T694-p	ARQSRRstQGVTLTD
T698	RRstQGVTLTDLQEA
T700	stQGVTLTDLQEAEK
T708	DLQEAEKTIGRSRST
S714	KTIGRSRSTRTREQE
T715	TIGRSRSTRTREQEN
K741	DKEKQEEKKESEASR
A746	EEKKESEASREDEYK
S747	EKKESEASREDEYKQ
Y752	EASREDEYKQKySRT
K753	ASREDEYKQKySRTY
Y756-p	EDEYKQKySRTYDET
S757	DEYKQKySRTYDETy
T759	YKQKySRTYDETyTR
Y760	KQKySRTYDETyTRy
T763	ySRTYDETyTRyRPV
Y764-p	SRTYDETyTRyRPVS
Y767-p	YDETyTRyRPVSTSS
S780	SSSSAPSSSSLSTLG
T789-p	SLSTLGStLYASSQL
Y791	STLGStLYASSQLNR
S793	LGStLYASSQLNRPN
S794	GStLYASSQLNRPNs
S801-p	SQLNRPNsLVGITSA
Y809	LVGITSAYSRGLAkE
S810	VGITSAYSRGLAkEN
K815-u	AYSRGLAkENEREGE
S834-p	EKEGEDKsQPKsIRE
S838-p	EDKsQPKsIRERRRP
S851-p	RPREKRRstGVSFWt
T852-p	PREKRRstGVSFWtQ
S855	KRRstGVSFWtQDsD
T858-p	stGVSFWtQDsDENE
S861-p	VSFWtQDsDENEQER
S870-p	ENEQERQsDtEDGSS
T872-p	EQERQsDtEDGSSKR
S876	QsDtEDGSSKRETQT
T883	SSKRETQTDSVSRYD
S885	KRETQTDSVSRYDsS
S887	ETQTDSVSRYDsSST
Y889	QTDSVSRYDsSSTSS
S891-p	DSVSRYDsSSTSSSD
S892	SVSRYDsSSTSSSDR
S893	VSRYDsSSTSSSDRy
S895	RYDsSSTSSSDRyDs
Y900-p	STSSSDRyDsLLGRs
S902-p	SSSDRyDsLLGRsAs
S907-p	yDsLLGRsAsySYLE
S909-p	sLLGRsAsySYLEDR
Y910-p	LLGRsAsySYLEDRK
S911	LGRsAsySYLEDRKP
Y912	GRsAsySYLEDRKPY
Y919	YLEDRKPYSSRLEKD
S920	LEDRKPYSSRLEKDD
S921	EDRKPYSSRLEKDDS
Y935	STDFKKLYEQILAEN
S994-p	RALERRIsEMEEELK
K1001	sEMEEELKMLPDLKA
K1007	LKMLPDLKADNQRLK

	rat
K9	KMADAKQKRNEQLKR
S20	QLKRWIGSETDLEPP
T22	KRWIGSETDLEPPVV
Y68	HRGADINYANVDGLT
K285	GYLEELQKKQNLLHS
K286	YLEELQKKQNLLHSE
S299	SEKRDKKSPLIESTA
S304	KKSPLIESTANMENN
P313	ANMENNQPQKTFKNK
K320	PQKTFKNKETLIIEP
S353	EEGKKDESSCSSEED
S354	EGKKDESSCSSEEDE
S367	DEEDDSESEAETDKT
T371	DSESEAETDKTKPMA
T381	TKPMASVTNAHTAST
T406	TLSSNQGTPTSPVKK
S409	SNQGTPTSPVKKFPT
S417	PVKKFPTSTTKISPK
T419	KKFPTSTTKISPKEE
S422	PTSTTKISPKEEERK
S432-p	EEERKDEsPASWRLG
K442	SWRLGLRKTGsyGAL
T443	WRLGLRKTGsyGALA
S445-p	LGLRKTGsyGALAEI
Y446-p	GLRKTGsyGALAEIT
T453	yGALAEITASKEAQK
K456	LAEITASKEAQKEKD
K460	TASKEAQKEKDTAGV
T464	EAQKEKDTAGVIRSA
S470	DTAGVIRSASsPRLS
S472	AGVIRSASsPRLSSS
S473-p	GVIRSASsPRLSSSL
S477	SASsPRLSSSLDNKE
S478	ASsPRLSSSLDNKEK
S479	SsPRLSSSLDNKEKE
Y496	NKGTRLAYVAPTIPR
A498	GTRLAYVAPTIPRRL
T500	RLAYVAPTIPRRLGs
S507-p	TIPRRLGstsDIEEK
T508-p	IPRRLGstsDIEEKE
S509-p	PRRLGstsDIEEKEN
S520	EKENRESSNLRTSSS
N521	KENRESSNLRTSSSY
S525	ESSNLRTSSSYTRRK
S526	SSNLRTSSSYTRRKW
S527	SNLRTSSSYTRRKWE
T529	LRTSSSYTRRKWEDD
S541	EDDLKKNSSINEGST
S542	DDLKKNSSINEGSTY
S547	NSSINEGSTYHRSCS
T548	SSINEGSTYHRSCSF
Y549	SINEGSTYHRSCSFG
S552	EGSTYHRSCSFGRRQ
S554	STYHRSCSFGRRQDD
T571	SCSVPSTTSTPTVTS
T573	SVPSTTSTPTVTSAA
T575	PSTTSTPTVTSAAGL
S578	TSTPTVTSAAGLQKS
S591	KSFLSSTSTTAKTPP
T596	STSTTAKTPPGSsPA
S601-p	AKTPPGSsPAGTQSS
S607	SsPAGTQSSTSNRLW
S618	NRLWAEDSTEKEKDS
T619	RLWAEDSTEKEKDSA
T631	DSAPTAATILVAPTV
T646	VSAAASSTTALTTTT
A648	AAASSTTALTTTTAG
T653	TTALTTTTAGTLSST
S669-p	EVRERRRsYLTPVRD
Y670	VRERRRsYLTPVRDE
T672	ERRRsYLTPVRDEES
S679	TPVRDEESESQRKAR
S681	VRDEESESQRKARSR
S693	RSRQARQSRRstQGV
S696-p	QARQSRRstQGVTLT
T697-p	ARQSRRstQGVTLTD
T701	RRstQGVTLTDLQEA
T703	stQGVTLTDLQEAEK
T711	DLQEAEKTIGRSRST
S717	KTIGRSRSTRTREQE
T718	TIGRSRSTRTREQEN
K744	DKEKQEEKKESEVSR
V749	EEKKESEVSREDEYK
S750	EKKESEVSREDEYKQ
Y755	EVSREDEYKQKYSRT
K756	VSREDEYKQKYSRTY
Y759	EDEYKQKYSRTYDET
S760	DEYKQKYSRTYDETY
T762	YKQKYSRTYDETYAR
Y763	KQKYSRTYDETYARY
T766	YSRTYDETYARYRPV
Y767	SRTYDETYARYRPVS
Y770	YDETYARYRPVSTSS
S783	SSSSTPSSSSLSTLG
S792	SLSTLGSSLYASSQL
Y794	STLGSSLYASSQLNR
S796	LGSSLYASSQLNRPN
S797	GSSLYASSQLNRPNS
S804	SQLNRPNSLVGITSA
Y812	LVGITSAYSRGLTKD
S813	VGITSAYSRGLTKDN
K818	AYSRGLTKDNEREGE
S837	EKEGEDKSQPKSIRE
S841	EDKSQPKSIRERRRP
S854-p	RPREKRRstGVSFWT
T855-p	PREKRRstGVSFWTQ
S858	KRRstGVSFWTQDsD
T861	stGVSFWTQDsDENE
S864-p	VSFWTQDsDENEQER
S873	ENEQERQSDTEDGSS
T875	EQERQSDTEDGSSKR
S879	QSDTEDGSSKRDTQT
T886	SSKRDTQTDSVSRYD
S888	KRDTQTDSVSRYDSS
S890	DTQTDSVSRYDSSST
Y892	QTDSVSRYDSSSTSS
S894	DSVSRYDSSSTSSSD
S895	SVSRYDSSSTSSSDR
S896	VSRYDSSSTSSSDRY
S898	RYDSSSTSSSDRYDS
Y903	STSSSDRYDSLLGRS
S905	SSSDRYDSLLGRSAs
S910	YDSLLGRSAsYSYLE
S912-p	SLLGRSAsYSYLEER
Y913	LLGRSAsYSYLEERK
S914	LGRSAsYSYLEERKP
Y915	GRSAsYSYLEERKPY
Y922	YLEERKPYGSRLEKD
G923	LEERKPYGSRLEKDD
S924	EERKPYGSRLEKDDS
Y938	STDFKKLYEQILAEN
S997-p	RALERRIsEMEEELK
K1004	sEMEEELKMLPDLKA
K1010	LKMLPDLKADNQRLK

	pig
K9	KMADAKQKRNEQLKR
S20	QLKRWIGSETDLEPP
T22	KRWIGSETDLEPPVV
Y68	HRGADINYANVDGLT
K285	GYLEELQKKQNLLHS
K286	YLEELQKKQNLLHSE
S299	SEKREKKSPLIESTA
S304	KKSPLIESTANMDNN
S313	ANMDNNQSQKTFKNK
K320	SQKTFKNKETLIIEP
S353	EEGKKDESSCSSEED
S354	EGKKDESSCSSEEDE
S367	DEEDDSESEAETDKT
T371	DSESEAETDKTKPMA
T381	TKPMAPVTNANTSST
T406	TLSSGQATPTSPIKK
S409	SGQATPTSPIKKFPT
P417	PIKKFPTPATKISPK
T419	KKFPTPATKISPKEE
S422	PTPATKISPKEEERK
S432	EEERKDESPASWRLG
K442	SWRLGLRKTGSYGAL
T443	WRLGLRKTGSYGALA
S445	LGLRKTGSYGALAEI
Y446	GLRKTGSYGALAEIT
T453	YGALAEITASKEAQK
K456	LAEITASKEAQKEKD
K460	TASKEAQKEKDTAGV
T464	EAQKEKDTAGVIRSA
S470	DTAGVIRSASSPRLS
S472	AGVIRSASSPRLSSS
S473	GVIRSASSPRLSSSL
S477	SASSPRLSSSLDNKE
S478	ASSPRLSSSLDNKEK
S479	SSPRLSSSLDNKEKE
Y496	NKGTRLAYVAPTIPR
A498	GTRLAYVAPTIPRRL
T500	RLAYVAPTIPRRLAS
S507	TIPRRLASTSDMEEK
T508	IPRRLASTSDMEEKE
S509	PRRLASTSDMEEKEN
L520	EKENRDSLGLRTSSS
G521	KENRDSLGLRTSSSY
S525	DSLGLRTSSSYTRRK
S526	SLGLRTSSSYTRRKW
S527	LGLRTSSSYTRRKWE
T529	LRTSSSYTRRKWEDD
S541	EDDLKKNSSINEGST
S542	DDLKKNSSINEGSTY
S547	NSSINEGSTYQKSCS
T548	SSINEGSTYQKSCSF
Y549	SINEGSTYQKSCSFG
S552	EGSTYQKSCSFGRRQ
S554	STYQKSCSFGRRQDD
T571	SSSVPSTTSTPTVTS
T573	SVPSTTSTPTVTSAA
T575	PSTTSTPTVTSAAGL
S578	TSTPTVTSAAGLQKG
S591	KGLLSSTSTTTKITT
I596	STSTTTKITTGSSSA
S601	TKITTGSSSAGTQSS
S607	SSSAGTQSSTSNRVW
S618	NRVWAEDSTEKDKDS
T619	RVWAEDSTEKDKDSV
T631	DSVPTALTVPVAPAV
T645	VVNAAAATTTLTTTT
T647	NAAAATTTLTTTTAG
T652	TTTLTTTTAGTVSST
S668	EVRERRRSYLTPVRD
Y669	VRERRRSYLTPVRDE
T671	ERRRSYLTPVRDEES
S678	TPVRDEESESQRKAR
S680	VRDEESESQRKARSR
S692	RSRQARQSRRStQGV
S695	QARQSRRStQGVTLT
T696-p	ARQSRRStQGVTLTD
T700	RRStQGVTLTDLQEA
T702	StQGVTLTDLQEAEK
T710	DLQEAEKTIGRSRST
S716	KTIGRSRSTRTREQE
T717	TIGRSRSTRTREQEN
K743	DKEKQEEKKESETSR
T748	EEKKESETSREDEYK
S749	EKKESETSREDEYKQ
Y754	ETSREDEYKQKYSRT
K755	TSREDEYKQKYSRTF
Y758	EDEYKQKYSRTFDET
S759	DEYKQKYSRTFDETY
T761	YKQKYSRTFDETYQR
F762	KQKYSRTFDETYQRY
T765	YSRTFDETYQRYRPA
Y766	SRTFDETYQRYRPAS
Y769	FDETYQRYRPASTSG
S781	TSGSATPSSSLSTMS
S790	SLSTMSSSLYASSQL
Y792	STMSSSLYASSQLNR
S794	MSSSLYASSQLNRPN
S795	SSSLYASSQLNRPNS
S802	SQLNRPNSLVGITSA
Y810	LVGITSAYSRGST__
S811	VGITSAYSRGST___
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	chicken
K9	KMADAKQKRNEQLKR
S20	QLKRWIGSETDLEPP
T22	KRWIGSETDLEPPVV
Y68	ERGADINYANVDGLT
K285	GYLEELQKKQNLLHS
K286	YLEELQKKQNLLHSE
S299	SEKREKKSPLIESTA
S304	KKSPLIESTANLDNN
T313	ANLDNNQTQKTFKNK
K320	TQKTFKNKETLIMEQ
S353	EEGKKDESSCSSEEE
S354	EGKKDESSCSSEEEE
S367	EEDDDSESEAETDKA
T371	DSESEAETDKAKTLA
-	gap
T401	SVAGGQGTPTSPLKK
S404	GGQGTPTSPLKKFPT
S412	PLKKFPTSTTKVSPK
T414	KKFPTSTTKVSPKEE
S417	PTSTTKVSPKEEERK
S427	EEERKDESPASWRLG
K437	SWRLGLRKTGSYGAL
T438	WRLGLRKTGSYGALA
S440	LGLRKTGSYGALAEI
Y441	GLRKTGSYGALAEIT
T448	YGALAEITASKEAQK
K451	LAEITASKEAQKEKD
K455	TASKEAQKEKDSAGV
S459	EAQKEKDSAGVIRSA
S465	DSAGVIRSASSPRLS
S467	AGVIRSASSPRLSSS
S468	GVIRSASSPRLSSSL
S472	SASSPRLSSSLDNKE
S473	ASSPRLSSSLDNKEK
S474	SSPRLSSSLDNKEKE
Y491	GKGTRLAYVAPtIPR
A493	GTRLAYVAPtIPRRL
T495-p	RLAYVAPtIPRRLAS
S502	tIPRRLASTSDIDEK
T503	IPRRLASTSDIDEKE
S504	PRRLASTSDIDEKEN
S515	EKENRDSSASSIRSG
S518	NRDSSASSIRSGSSY
G522	SASSIRSGSSYARRK
S523	ASSIRSGSSYARRKW
S524	SSIRSGSSYARRKWE
A526	IRSGSSYARRKWEED
S538	EEDVKKNSLNEGPTS
-	gap
T548	EGPTSLNTSYQRSGS
S549	GPTSLNTSYQRSGSF
Y550	PTSLNTSYQRSGSFG
S553	LNTSYQRSGSFGRRQ
S555	TSYQRSGSFGRRQDD
A572	SSNVPSTASTVTSSA
T574	NVPSTASTVTSSAGL
-	gap
S577	STASTVTSSAGLQKT
N590	KTLPASANTTTKSTT
S595	SANTTTKSTTGSTSA
T600	TKSTTGSTSAGVQSS
S606	STSAGVQSSTSNRLW
S617	NRLWAEDSTEKEKDS
T618	RLWAEDSTEKEKDSV
T630	DSVPTAVTVPVAPSV
T644	VVNAAATTTAMTTAT
A646	NAAATTTAMTTATSG
T651	TTAMTTATSGTVSST
S667-p	EVRERRRsYLTPVRD
Y668	VRERRRsYLTPVRDE
T670	ERRRsYLTPVRDEES
S677	TPVRDEESESQRKAR
S679	VRDEESESQRKARSR
S691	RSRQARQSRRstQGV
S694-p	QARQSRRstQGVTLT
T695-p	ARQSRRstQGVTLTD
T699	RRstQGVTLTDLQEA
T701	stQGVTLTDLQEAEK
T709-p	DLQEAEKtIGRSRSt
S715	KtIGRSRStRTREQE
T716-p	tIGRSRStRTREQEN
K742	DKEKQEEKKESETKD
T747	EEKKESETKDDDYRQ
-	gap
Y752	SETKDDDYRQRYSRT
R753	ETKDDDYRQRYSRTV
Y756	DDDYRQRYSRTVEEP
S757	DDYRQRYSRTVEEPY
T759	YRQRYSRTVEEPYHR
V760	RQRYSRTVEEPYHRY
P763	YSRTVEEPYHRYRPT
Y764	SRTVEEPYHRYRPTS
Y767	VEEPYHRYRPTSTST
T779	TSTSTSSTSSLSTST
S788	SLSTSTSSLSSSSQL
S790	STSTSSLSSSSQLNR
S792	STSSLSSSSQLNRPN
S793	TSSLSSSSQLNRPNS
S800	SQLNRPNSLIGITSA
Y808	LIGITSAYSRSGTKE
S809	IGITSAYSRSGTKES
K814	AYSRSGTKESEREGG
S832	EEKEEDKSQPKSIRE
S836	EDKSQPKSIRERRRP
S849-p	RPREKRRstGVSFWT
T850-p	PREKRRstGVSFWTQ
S853	KRRstGVSFWTQDSD
T856	stGVSFWTQDSDENE
S859	VSFWTQDSDENEQEH
S868	ENEQEHQSDSEEGTN
S870	EQEHQSDSEEGTNKK
T874	QSDSEEGTNKKETQS
S881	TNKKETQSDSLSRYD
S883	KKETQSDSLSRYDTG
S885	ETQSDSLSRYDTGSL
Y887	QSDSLSRYDTGSLSV
T889	DSLSRYDTGSLSVSS
S891	LSRYDTGSLSVSSGD
S893	RYDTGSLSVSSGDRY
S895	DTGSLSVSSGDRYDS
Y900	SVSSGDRYDSAQGRS
S902	SSGDRYDSAQGRSGS
S907	YDSAQGRSGSQSYLE
S909	SAQGRSGSQSYLEDR
Q910	AQGRSGSQSYLEDRK
S911	QGRSGSQSYLEDRKP
Y912	GRSGSQSYLEDRKPY
Y919	YLEDRKPYCSRLEKE
C920	LEDRKPYCSRLEKED
S921	EDRKPYCSRLEKEDS
Y935	STDFKKLYEQILAEN
-	gap
-	gap
-	gap

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