a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors.. Seems to activate the transcription of growth-related genes. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Molecular Function: protein dimerization activity; protein binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; double-stranded DNA binding; protein complex binding; transcription factor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; positive regulation of catalytic activity; response to alkaloid; positive regulation of apoptosis; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; transcription initiation; regulation of mitotic cell cycle; B cell apoptosis; positive regulation of caspase activity; middle ear morphogenesis; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; chromosome organization and biogenesis; regulation of apoptosis; response to radiation; positive regulation of fibroblast proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to gamma radiation; DNA fragmentation during apoptosis; cell cycle arrest; negative regulation of protein binding; caspase activation; release of cytochrome c from mitochondria; Wnt receptor signaling pathway; positive regulation of B cell apoptosis; transcription, DNA-dependent; regulation of telomere maintenance; MAPKKK cascade; glucose metabolic process; negative regulation of cell division; detection of mechanical stimulus involved in sensory perception of sound; negative regulation of monocyte differentiation; chromatin remodeling; pigmentation; regulation of gene expression; ureteric bud branching; skeletal morphogenesis; negative regulation of fibroblast proliferation; protein processing; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.