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Myc (mouse)

Overview Myc a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors.. Seems to activate the transcription of growth-related genes. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: nucleoplasm; nuclear body; protein complex; axon; cytoplasm; nucleolus; spindle; nucleus Molecular Function: protein dimerization activity; protein binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; double-stranded DNA binding; protein complex binding; transcription factor activity; transcription factor binding Biological Process: transcription from RNA polymerase II promoter; positive regulation of catalytic activity; response to alkaloid; positive regulation of apoptosis; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; transcription initiation; regulation of mitotic cell cycle; B cell apoptosis; positive regulation of caspase activity; middle ear morphogenesis; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; chromosome organization and biogenesis; regulation of apoptosis; response to radiation; positive regulation of fibroblast proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to gamma radiation; DNA fragmentation during apoptosis; cell cycle arrest; negative regulation of protein binding; caspase activation; release of cytochrome c from mitochondria; Wnt receptor signaling pathway; positive regulation of B cell apoptosis; transcription, DNA-dependent; regulation of telomere maintenance; MAPKKK cascade; glucose metabolic process; negative regulation of cell division; detection of mechanical stimulus involved in sensory perception of sound; negative regulation of monocyte differentiation; chromatin remodeling; pigmentation; regulation of gene expression; ureteric bud branching; skeletal morphogenesis; negative regulation of fibroblast proliferation; protein processing; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation Reference #:  P01108 (UniProtKB) Alt. Names/Synonyms: AU016757; bHLHe39; c-myc proto-oncogene; Myc; Myc proto-oncogene protein; Myc2; myelocytomatosis oncogene; Niard; Nird; Proto-oncogene c-Myc; Transcription factor p64 Gene Symbols: Myc Molecular weight: 48,971 Da Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  MAPK/Erk in Growth and Differentiation  |  Signaling Pathways Activating p38 MAPK  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Myc 1A93 - A=406-434 (human) 1EE4 - C/D/E/F=320-328 (human) 1MV0 - A=55-68 (human) 1NKP - A/D=353-434 (human) 2A93 - A=406-434 (human)

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	Sites Implicated In
apoptosis, inhibited: T358‑p, S373‑p, T400‑p cell cycle regulation: T358‑p, S373‑p, T400‑p cell differentiation, altered: T58‑p cell growth, altered: S329‑p, T358‑p, S373‑p, T400‑p transcription, altered: S62‑p, S329‑p, T358‑p, S373‑p, T400‑p inhibition: T358‑p, S373‑p, T400‑p molecular association, regulation: T58‑p, S62‑p, S373‑p, T400‑p phosphorylation: S62‑p protein degradation: T58‑p protein stabilization: S62‑p, S329‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	2		N6	__MPLNVNFTNRNYD
1	0		T8	MPLNVNFTNRNYDLD
1	0		Y12	VNFTNRNYDLDYDSV
1	2		Y16	NRNYDLDYDSVQPYF
1	0		Y22	DYDSVQPYFICDEEE
1	0		Y32	CDEEENFYHQQQQSE
0	1		K52	PSEDIWKKFELLPtP
39	33		T58-p	KKFELLPtPPLsPsR
2	0		T58	KKFELLPTPPLsPsR
31	35		S62-p	LLPtPPLsPsRRsGL
1	10		S64-p	PtPPLsPsRRsGLCS
2	2		S67-p	PLsPsRRsGLCSPSy
3	2		S71	sRRsGLCSPSyVAVA
1	1		Y74-p	sGLCSPSyVAVAtSF
0	1		T79-p	PSyVAVAtSFSPRED
0	1		S137-p	IIQDCMWsGFsAAAK
0	1		S140-p	DCMWsGFsAAAKLVS
2	0		K144	sGFsAAAKLVSEkLA
2	21		K149-a	AAKLVSEkLASYQAA
0	55		K149-u	AAKLVSEkLASYQAA
2	0		K158	ASYQAARKDSTSLSP
0	1		K158	ASYQAARKDSTSLSP
0	1		S162	AARKDSTSLSPARGH
1	0		S249	EETPPTTSSDSEEEQ
1	0		S250	ETPPTTSSDSEEEQE
2	0		S252	PPTTSSDSEEEQEDE
2	0		K275	EKRQTPAKRSESGSS
0	1		S279	TPAKRSESGSSPSRG
0	1		S288	SSPSRGHSKPPHsPL
0	9		S293-p	GHSKPPHsPLVLKRC
2	0		K317	AAPPSTRKDYPAAkR
3	5		K323-a	RKDYPAAkRAKLDsG
0	1		K323	RKDYPAAKRAKLDsG
1	0		S329-p	AkRAKLDsGRVLKQI
0	1		S337	GRVLKQISNNRKCSS
0	1		S343	ISNNRKCSSPRSSDT
1	0		S347	RKCSSPRSSDTEEND
1	0		S348	KCSSPRSSDTEENDK
0	1		K355	SDTEENDKRRtHNVL
3	0		T358-p	EENDKRRtHNVLERQ
2	0		K371	RQRRNELKRsFFALR
4	1		S373-p	RRNELKRsFFALRDQ
0	4		K389	PELENNEKAPKVVIL
3	0		T400-p	VVILKKAtAYILSIQ
0	1		S405	KAtAYILSIQADEHK
0	1		K412	SIQADEHKLTSEkDL
1	0		K417-a	EHKLTSEkDLLRKRR

	human
S6-p	__MPLNVsFtNRNyD
T8-p	MPLNVsFtNRNyDLD
Y12-p	VsFtNRNyDLDyDSV
Y16-p	NRNyDLDyDSVQPyF
Y22-p	DyDSVQPyFYCDEEE
Y32-p	CDEEENFyQQQQQSE
K52-u	PSEDIWKkFELLPtP
T58-p	KkFELLPtPPLsPsR
T58-g	KkFELLPtPPLsPsR
S62-p	LLPtPPLsPsRRsGL
S64-p	PtPPLsPsRRsGLCs
S67-p	PLsPsRRsGLCsPSy
S71-p	sRRsGLCsPSyVAVT
Y74-p	sGLCsPSyVAVTPFS
T78	sPSyVAVTPFSLRGD
S136	IIQDCMWSGFSAAAk
S139	DCMWSGFSAAAkLVS
K143-a	SGFSAAAkLVSEkLA
K148-a	AAkLVSEkLASYQAA
K148-u	AAkLVSEkLASYQAA
K157-a	ASYQAARkDSGsPNP
K157-u	ASYQAARkDSGsPNP
S161-p	AARkDSGsPNPARGH
S249-p	EETPPTTssDsEEEQ
S250-p	ETPPTTssDsEEEQE
S252-p	PPTTssDsEEEQEDE
K275-a	EKRQAPGkRSEsGSP
S279-p	APGkRSEsGSPSAGG
S288-p	SPSAGGHsKPPHsPL
S293-p	GHsKPPHsPLVLKRC
K317-a	AAPPSTRkDYPAAkR
K323-a	RkDYPAAkRVKLDSV
K323-u	RkDYPAAkRVKLDSV
S329	AkRVKLDSVRVLRQI
S337-p	VRVLRQIsNNRKCtS
T343-p	IsNNRKCtSPRssDT
S347-p	RKCtSPRssDTEENV
S348-p	KCtSPRssDTEENVk
K355-u	sDTEENVkRRtHNVL
T358-p	EENVkRRtHNVLERQ
K371-a	RQRRNELkRsFFALR
S373-p	RRNELkRsFFALRDQ
K389-u	PELENNEkAPKVVIL
T400-p	VVILKKAtAYILsVQ
S405-p	KAtAYILsVQAEEQk
K412-u	sVQAEEQkLISEEDL
E417	EQkLISEEDLLRKRR

	rat
S6	__MPLNVSFANRNYD
A8	MPLNVSFANRNYDLD
Y12	VSFANRNYDLDYDSV
Y16	NRNYDLDYDSVQPYF
Y22	DYDSVQPYFICDEEE
Y32	CDEEENFYHQQQQSE
K52	PSEDIWKKFELLPTP
T58	KKFELLPTPPLSPSR
T58	KKFELLPTPPLSPSR
S62	LLPTPPLSPSRRSGL
S64	PTPPLSPSRRSGLCS
S67	PLSPSRRSGLCSPSY
S71	SRRSGLCSPSYVAVA
Y74	SGLCSPSYVAVATSF
T79	PSYVAVATSFSPRED
S137	IIQDCMWSGFSAAAK
S140	DCMWSGFSAAAKLVS
K144	SGFSAAAKLVSEKLA
K149	AAKLVSEKLASYQAA
K149	AAKLVSEKLASYQAA
K158	ASYQAARKDSTSLSP
K158	ASYQAARKDSTSLSP
S162	AARKDSTSLSPARGH
S249	EETPPTTSSDSEEEQ
S250	ETPPTTSSDSEEEQD
S252	PPTTSSDSEEEQDDE
K275	EKRQPPAKRSESGSS
S279	PPAKRSESGSSPSRG
S288	SSPSRGHSKPPHSPL
S293	GHSKPPHSPLVLKRC
K317	AAPPSTRKDYPAAKR
K323	RKDYPAAKRAKLDSG
K323	RKDYPAAKRAKLDSG
S329	AKRAKLDSGRVLKQI
S337	GRVLKQISNNRKCSS
S343	ISNNRKCSSPRSSDT
S347	RKCSSPRSSDTEEND
S348	KCSSPRSSDTEENDK
K355	SDTEENDKRRTHNVL
T358	EENDKRRTHNVLERQ
K371	RQRRNELKRSFFALR
S373	RRNELKRSFFALRDQ
K389	PELENNEKAPKVVIL
T400	VVILKKATAYILSVQ
S405	KATAYILSVQADEHK
K412	SVQADEHKLISEKDL
K417	EHKLISEKDLLRKRR

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