a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors.. Seems to activate the transcription of growth-related genes. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Transcription factor; DNA binding protein
Molecular Function: protein dimerization activity; protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; double-stranded DNA binding; protein complex binding; transcription factor binding; transcription factor activity
Biological Process: positive regulation of catalytic activity; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; transcription initiation; regulation of mitotic cell cycle; positive regulation of caspase activity; B cell apoptosis; Wnt receptor signaling pathway through beta-catenin; middle ear morphogenesis; regulation of apoptosis; positive regulation of fibroblast proliferation; positive regulation of mesenchymal cell proliferation; cell cycle arrest; negative regulation of protein binding; inner mitochondrial membrane organization and biogenesis; positive regulation of B cell apoptosis; regulation of telomere maintenance; transcription, DNA-dependent; glucose metabolic process; positive regulation of cell cycle; pyruvate transport; detection of mechanical stimulus involved in sensory perception of sound; DNA damage response, signal transduction resulting in induction of apoptosis; regulation of gene expression; negative regulation of fibroblast proliferation; regulation of oxidative phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation; response to alkaloid; transcription from RNA polymerase II promoter; lactic acid secretion; negative regulation of transcription from RNA polymerase II promoter; chromosome organization and biogenesis; response to radiation; regulation of transcription, DNA-dependent; amino acid transport; positive regulation of cell proliferation; response to gamma radiation; caspase activation; Wnt receptor signaling pathway; MAPKKK cascade; negative regulation of cell division; negative regulation of monocyte differentiation; chromatin remodeling; cell proliferation; negative regulation of glucose import; pigmentation; ureteric bud branching; skeletal morphogenesis; positive regulation of glycolysis; protein processing; response to DNA damage stimulus; transformation of host cell by virus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.