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G-alpha1(i) (human)

Overview G-alpha1(i) Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Interacts with GPSM1. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains); the interaction occurs in the centrosomes. Interacts (GDP-bound form) with RIC8A (via C-terminus). Interacts with DRD2. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Note: This description may include information from UniProtKB. Protein type: G protein, heterotrimeric alpha G((i/o/t/z)); G protein; G protein, heterotrimeric Cellular Component: centrosome; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; midbody; nucleus Molecular Function: GTPase activity; signal transducer activity; protein binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; metabotropic serotonin receptor binding Biological Process: platelet activation; response to peptide hormone stimulus; G-protein coupled receptor protein signaling pathway; synaptic transmission; cell division; GTP catabolic process; G-protein signaling, adenylate cyclase inhibiting pathway; cell cycle; blood coagulation Reference #:  P63096 (UniProtKB) Alt. Names/Synonyms: Adenylate cyclase-inhibiting G alpha protein; Gi; Gi1 protein alpha subunit; GNAI1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; Guanine nucleotide-binding protein G(i) subunit alpha-1 Gene Symbols: GNAI1 Molecular weight: 40,361 Da Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states CST Pathways:  Hedgehog Signaling  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below G-alpha1(i) 1KJY - A/C=31-354 (human) 1Y3A - A/B/C/D=26-354 (human) 2EBC - A=1-354 (human) 2G83 - A/B=33-345 (human) 2GTP - A/B=32-354 (human) 2HLB - A=1-354 (human) 2IK8 - A/C=31-354 (human) 2OM2 - A/C=31-354 (human) 2PZ2 - A=1-354 (human) 2PZ3 - A=1-354 (human) 2XNS - A/B=30-354 (human) 3ONW - A/B=31-354 (human) 3QE0 - A/C/B=33-354 (human) 3QI2 - A/B=31-354 (human) 3UMR - A=1-354 (human) 3UMS - A=1-354 (human) 4G5Q - H/F/G/E=628-652 (human) 1AGR - A/D=1-353 (rat) 1AS0 - A=1-353 (rat) 1AS2 - A=1-353 (rat) 1AS3 - A=1-353 (rat) 1BH2 - A=31-345 (rat) 1BOF - A=1-353 (rat) 1CIP - A=2-354 (rat) 1GDD - A=1-353 (rat) 1GFI - A=1-353 (rat) 1GG2 - A=1-353 (rat) 1GIA - A=1-353 (rat) 1GIL - A=1-353 (rat) 1GIT - A=1-353 (rat) 1GP2 - A=1-353 (rat) 1SVK - A=1-353 (rat) 1SVS - A=1-353 (rat) 2RGN - A/D=1-28 (rat) 2ZJY - A=1-354 (rat) 2ZJZ - A/B=1-354 (rat) 3AH8 - A=2-28 (rat) 3D7M - A=1-354 (rat) 3FFA - A=33-348 (rat) 3FFB - A=6-354 (rat) 3V00 - A/C/B=220-298 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1KJY 1Y3A 2EBC 2G83 2GTP 2HLB 2IK8 2OM2 2PZ2 2PZ3 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q  |  Phospho3D  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	11		K29-u	NLREDGEkAAREVkL
0	2		K35-a	EkAAREVkLLLLGAG
0	3		K35-u	EkAAREVkLLLLGAG
0	47		K46-u	LGAGESGkSTIVkQM
0	42		K51-u	SGkSTIVkQMKIIHE
0	1		K54	STIVkQMKIIHEAGY
0	1		K67	GYSEEECKQYKAVVY
0	1		Y69	SEEECKQYKAVVYSN
0	11		K92-u	IRAMGRLkIDFGDSA
0	1		S98	LkIDFGDSARADDAR
0	1		K128	AELAGVIKRLWKDSG
0	9		K132	GVIKRLWKDSGVQAC
0	1		Y155-p	LNDSAAYyLNDLDRI
0	6		K180	DVLRTRVKTTGIVET
0	3		K192-u	VETHFTFkDLHFkMF
0	1		K197-a	TFkDLHFkMFDVGGQ
0	3		K197-u	TFkDLHFkMFDVGGQ
0	1		K248-a	NRMHESMkLFDSICN
0	12		K248-u	NRMHESMkLFDSICN
0	5		K271	IILFLNKKDLFEEKI
0	2		K277	KKDLFEEKIKKSPLT
0	1		Y290	LTICYPEYAGSNTYE
0	1		S293	CYPEYAGSNTYEEAA
0	8		K312	CQFEDLNKRKDTKEI
0	2		K345-u	AVTDVIIkNNLkDCG
0	8		K349-u	VIIkNNLkDCGLF__

	mouse
K29-u	NLREDGEkAAREVkL
K35	EkAAREVKLLLLGAG
K35-u	EkAAREVkLLLLGAG
K46-u	LGAGESGkSTIVkQM
K51-u	SGkSTIVkQMkIIHE
K54-u	STIVkQMkIIHEAGY
K67-u	GYSEEECkQYKAVVY
Y69	SEEECkQYKAVVYSN
K92-u	IRAMGRLkIDFGDsA
S98-p	LkIDFGDsARADDAR
K128-a	AELAGVIkRLWkDSG
K132-u	GVIkRLWkDSGVQAC
Y155	LNDSAAYYLNDLDRI
K180-u	DVLRTRVkTTGIVET
K192-u	VETHFTFkDLHFkMF
K197	TFkDLHFKMFDVGGQ
K197-u	TFkDLHFkMFDVGGQ
K248	NRMHESMKLFDSICN
K248-u	NRMHESMkLFDSICN
K271-u	IILFLNKkDLFEEkI
K277-u	KkDLFEEkIKKSPLT
Y290-p	LTICYPEyAGsNTYE
S293-p	CYPEyAGsNTYEEAA
K312-u	CQFEDLNkRKDTKEI
K345-u	AVTDVIIkNNLkDCG
K349-u	VIIkNNLkDCGLF__

	rat
K29-u	NLREDGEkAAREVkL
K35-a	EkAAREVkLLLLGAG
K35	EkAAREVKLLLLGAG
K46-u	LGAGESGkSTIVkQM
K51-u	SGkSTIVkQMKIIHE
K54	STIVkQMKIIHEAGY
K67	GYSEEECKQyKAVVY
Y69-p	SEEECKQyKAVVYSN
K92	IRAMGRLKIDFGDAA
A98	LKIDFGDAARADDAR
K128	AELAGVIKRLWKDSG
K132	GVIKRLWKDSGVQAC
Y155	LNDSAAYYLNDLDRI
K180	DVLRTRVKTTGIVET
K192	VETHFTFKDLHFkMF
K197-a	TFKDLHFkMFDVGGQ
K197	TFKDLHFKMFDVGGQ
K248-a	NRMHESMkLFDSICN
K248	NRMHESMKLFDSICN
K271	IILFLNKKDLFEEKI
K277	KKDLFEEKIKKSPLT
Y290	LTICYPEYAGSNTYE
S293	CYPEYAGSNTYEEAA
K312	CQFEDLNKRKDTKEI
K345	AVTDVIIKNNLKDCG
K349	VIIKNNLKDCGLF__

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