galectin-1
May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N- acetyllactosamine). Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion. Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. Note: This description may include information from UniProtKB.
Molecular Function: signal transducer activity; protein homodimerization activity; lactose binding; galactoside binding; laminin binding; glycoprotein binding
Biological Process: myoblast differentiation; regulation of apoptosis; response to drug; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; positive regulation of erythrocyte aggregation; response to axon injury; signal transduction; multicellular organismal response to stress
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.
