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Protein Page:
Galectin-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Galectin-1 May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N- acetyllactosamine). Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion. Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; cell surface; cytoplasm; intracellular; nucleus
Molecular Function: signal transducer activity; protein binding; protein homodimerization activity; lactose binding; laminin binding; galactoside binding; glycoprotein binding
Biological Process: regulation of apoptosis; myoblast differentiation; response to drug; positive regulation of I-kappaB kinase/NF-kappaB cascade; plasma cell differentiation; apoptosis; T cell costimulation; positive regulation of erythrocyte aggregation; response to axon injury; signal transduction; multicellular organismal response to stress
Reference #:  P09382 (UniProtKB)
Alt. Names/Synonyms: 14 kDa laminin-binding protein; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; DKFZp686E23103; Gal-1; GAL1; Galaptin; galectin 1; Galectin-1; GBP; HBL; HLBP14; HPL; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; lectin, galactoside-binding, soluble, 1; LEG1; LGALS1; Putative MAPK-activating protein PM12; S-Lac lectin 1
Gene Symbols: LGALS1
Molecular weight: 14,716 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Galectin-1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K13-sc VASNLNLkPGECLRV
0 1 P26 RVRGEVAPDAksFVL
0 12 K29-ac GEVAPDAksFVLNLG
0 7 K29-ub GEVAPDAksFVLNLG
0 1 K29-sc GEVAPDAksFVLNLG
0 7 S30-p EVAPDAksFVLNLGk
0 12 K37-ub sFVLNLGkDSNNLCL
0 1 S63-p ANTIVCNskDGGAWG
0 4 K64-ac NTIVCNskDGGAWGt
0 11 K64-ub NTIVCNskDGGAWGt
0 1 T71-p kDGGAWGtEQREAVF
0 18 Y105-p TVKLPDGyEFkFPNR
0 2 K108-ac LPDGyEFkFPNRLNL
0 7 K108-ub LPDGyEFkFPNRLNL
0 1 K108-sc LPDGyEFkFPNRLNL
0 1 Y120-p LNLEAINyMAADGDF
0 30 K128-ac MAADGDFkIkCVAFD
0 1 K128-ub MAADGDFkIkCVAFD
0 1 K130-ac ADGDFkIkCVAFD__
0 1 K130-ub ADGDFkIkCVAFD__
  mouse

 
K13 VASNLNLKPGECLKV
S26-p KVRGEVAsDAksFVL
K29 GEVAsDAKsFVLNLG
K29-ub GEVAsDAksFVLNLG
K29 GEVAsDAKsFVLNLG
S30-p EVAsDAksFVLNLGk
K37-ub sFVLNLGkDSNNLCL
T63 ANTIVCNTKEDGTWG
K64 NTIVCNTKEDGTWGT
K64 NTIVCNTKEDGTWGT
T71 KEDGTWGTEHREPAF
H105 TIKLPDGHEFkFPNR
K108-ac LPDGHEFkFPNRLNM
K108-ub LPDGHEFkFPNRLNM
K108 LPDGHEFKFPNRLNM
Y120 LNMEAINYMAADGDF
K128-ac MAADGDFkIKCVAFE
K128 MAADGDFKIKCVAFE
K130 ADGDFkIKCVAFE__
K130 ADGDFkIKCVAFE__
  rat

 
K13 VASNLNLKPGECLKV
P26 KVRGELAPDAksFVL
K29-ac GELAPDAksFVLNLG
K29 GELAPDAKsFVLNLG
K29 GELAPDAKsFVLNLG
S30-p ELAPDAksFVLNLGK
K37 sFVLNLGKDSNNLCL
S63 ANTIVCNSKDDGTWG
K64 NTIVCNSKDDGTWGT
K64 NTIVCNSKDDGTWGT
T71 KDDGTWGTEQRETAF
H105 TIKLPDGHEFkFPNR
K108-ac LPDGHEFkFPNRLNM
K108 LPDGHEFKFPNRLNM
K108 LPDGHEFKFPNRLNM
Y120 LNMEAINYMAADGDF
K128-ac MAADGDFkIKCVAFE
K128 MAADGDFKIKCVAFE
K130 ADGDFkIKCVAFE__
K130 ADGDFkIKCVAFE__
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