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Protein Page:
LPIN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LPIN1 Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription. Interacts with MEF2C. Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. Inhibited by N-ethylmaleimide. Belongs to the lipin family. Note: This description may include information from UniProtKB.
Protein type: Phosphatase, lipid; EC 3.1.3.4
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component: nucleoplasm; endoplasmic reticulum membrane; transcription factor complex; mitochondrial outer membrane; nuclear membrane; cytoplasm; nuclear envelope; cytosol; nucleus
Molecular Function: peroxisome proliferator activated receptor binding; phosphatidate phosphatase activity; histone deacetylase binding; transcription coactivator activity
Biological Process: mitochondrial fission; organ regeneration; transcription, DNA-dependent; regulation of fat cell differentiation; phosphatidylethanolamine biosynthetic process; glycerophospholipid biosynthetic process; mitotic nuclear envelope disassembly; triacylglycerol biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; fatty acid catabolic process; cellular lipid metabolic process; positive regulation of histone deacetylation; dephosphorylation; cellular response to insulin stimulus; phospholipid metabolic process; actin cytoskeleton reorganization; ruffle organization and biogenesis; phosphatidylcholine biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; triacylglycerol mobilization
Disease: Myoglobinuria, Acute Recurrent, Autosomal Recessive
Reference #:  Q14693 (UniProtKB)
Alt. Names/Synonyms: DKFZp781P1796; KIAA0188; lipin 1; Lipin-1; LPIN1; PAP1; Phosphatidate phosphatase LPIN1
Gene Symbols: LPIN1
Molecular weight: 98,664 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LPIN1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 23 T14-p LAGQVFVtVKELYKG
0 1 N42 VIRQPNGNLQCSPFH
2 1 S106-p IPMHLATsPILSEGA
0 1 S124 ECQLKRGSVDRMRGL
0 1 S134-p RMRGLDPstPAQVIA
0 1 T135-p MRGLDPstPAQVIAP
0 1 T145-p QVIAPSEtPSsSSVV
0 1 S148-p APSEtPSsSSVVKKR
0 1 S150 SEtPSsSSVVKKRRK
0 24 S162-p RRKRRRKsQLDsLKR
0 1 S166-p RRKsQLDsLKRDDNM
0 2 T175-p KRDDNMNtsEDEDMF
0 1 S176-p RDDNMNtsEDEDMFP
0 3 S187-p DMFPIEMssDEAMEL
0 3 S188-p MFPIEMssDEAMELL
1 0 S237 PNSDREWSPTPSPSG
0 1 - gap
0 2 - gap
0 2 - gap
0 1 - gap
0 1 S248 SPSGSRPStPKsDsE
0 3 T249-p PSGSRPStPKsDsEL
0 6 S252-p SRPStPKsDsELVSK
0 4 S254-p PStPKsDsELVSKST
0 2 S260 DsELVSKSTERTGQK
0 4 T264 VSKSTERTGQKNPEM
0 1 S293-p SPHKMKEssPLsSRK
0 6 S294-p PHKMKEssPLsSRKI
0 1 S297-p MKEssPLsSRKICDK
0 1 S298 KEssPLsSRKICDKS
0 1 I301 sPLsSRKICDKSHFQ
0 2 S319 SESSDTFSDQSPTLV
0 2 S322 SDTFSDQSPTLVGGA
0 1 T350 VNEEDLETLGAAAPL
0 2 L358 LGAAAPLLPMIEELK
0 4 S434-p ASDNGARsANQSPQS
1 3 S438 GARsANQSPQSVGSS
0 2 S441 sANQSPQSVGSSGVD
0 2 S445 SPQSVGSSGVDsGVE
0 6 S449-p VGSSGVDsGVESTSD
0 1 T479-p LSDHREItKDAFLEQ
0 2 T563-p SWRGRNTtIKEESKP
1 0 K565 RGRNTtIKEESKPEQ
0 1 S580-p CLAGKAHsTGEQPPQ
1 0 K595 LSLATRVKHESSSSD
0 3 S598 ATRVKHESSSSDEER
0 3 S599 TRVKHESSSSDEERA
0 4 S600 RVKHESSSSDEERAA
1 3 S601 VKHESSSSDEERAAA
0 1 A613 AAAKPSNAGHLPLLP
0 1 G614 AAKPSNAGHLPLLPN
0 1 P617 PSNAGHLPLLPNVSY
0 1 S686 IDGTITRSDTLGHIL
0 2 T688 GTITRSDTLGHILPT
0 1 S713-p AKLYHKVsQNGyKFL
0 1 Y717-p HKVsQNGyKFLYCSA
0 1 K770-ub LHREVIEkKPEKFKV
0 1 S814 SYKQVGVSLNRIFTV
0 1 T866 SDFPCSDTFSNFTFW
0 3 S887-p FENQDIHsASA____
0 5 S889 NQDIHsASA______
  LPIN1 iso3  
T14 LAGQVFVTVKELYKG
N42 VIRQPNGNLQCSPFH
S106 IPMHLATSPILSEGA
S124 ECQLKRGSVDRMRGL
S134 RMRGLDPSTPAQVIA
T135 MRGLDPSTPAQVIAP
T145 QVIAPSETPSSSSVV
S148 APSETPSSSSVVKKR
S150 SETPSSSSVVKKRRK
S162 RRKRRRKSQLDSLKR
S166 RRKSQLDSLKRDDNM
T175 KRDDNMNTSEDEDMF
S176 RDDNMNTSEDEDMFP
S187 DMFPIEMSSDEAMEL
S188 MFPIEMSSDEAMELL
S237 PNSDREWSPTPSSLV
T249 SLVDCKRTAPHLAVA
S264-p AEGGLSSsCPPQssL
S269-p SSsCPPQssLFHPSE
S270-p SsCPPQssLFHPSES
S284 SPSGSRPSTPKSDSE
T285 PSGSRPSTPKSDSEL
S288 SRPSTPKSDSELVSK
S290 PSTPKSDSELVSKST
S296 DSELVSKSTERTGQK
T300 VSKSTERTGQKNPEM
S329 SPHKMKESSPLSSRK
S330 PHKMKESSPLSSRKI
S333 MKESSPLSSRKICDK
S334 KESSPLSSRKICDKS
I337 SPLSSRKICDKSHFQ
S355 SESSDTFSDQSPTLV
S358 SDTFSDQSPTLVGGA
T386 VNEEDLETLGAAAPL
L394 LGAAAPLLPMIEELK
S470 ASDNGARSANQSPQS
S474 GARSANQSPQSVGSS
S477 SANQSPQSVGSSGVD
S481 SPQSVGSSGVDSGVE
S485 VGSSGVDSGVESTSD
T515 LSDHREITKDAFLEQ
T599 SWRGRNTTIKEESKP
K601 RGRNTTIKEESKPEQ
S616 CLAGKAHSTGEQPPQ
K631 LSLATRVKHESSSSD
S634 ATRVKHESSSSDEER
S635 TRVKHESSSSDEERA
S636 RVKHESSSSDEERAA
S637 VKHESSSSDEERAAA
A649 AAAKPSNAGHLPLLP
G650 AAKPSNAGHLPLLPN
P653 PSNAGHLPLLPNVSY
S722 IDGTITRSDTLGHIL
T724 GTITRSDTLGHILPT
S749 AKLYHKVSQNGYKFL
Y753 HKVSQNGYKFLYCSA
K806 LHREVIEKKPEKFKV
S850 SYKQVGVSLNRIFTV
T902 SDFPCSDTFSNFTFW
S923 FENQDIHSASA____
S925 NQDIHSASA______
  LPIN1 iso5  
T20 LAGQVFVTVKELYKG
N48 VIRQPNGNLQCSPFH
S112 IPMHLATSPILSEGA
S130 ECQLKRGSVDRMRGL
S140 RMRGLDPSTPAQVIA
T141 MRGLDPSTPAQVIAP
T151 QVIAPSETPSSSSVV
S154 APSETPSSSSVVKKR
S156 SETPSSSSVVKKRRK
S168 RRKRRRKSQLDSLKR
S172 RRKSQLDSLKRDDNM
T181 KRDDNMNTSEDEDMF
S182 RDDNMNTSEDEDMFP
S193 DMFPIEMSSDEAMEL
S194 MFPIEMSSDEAMELL
S243 PNSDREWSPTPSSLV
T255 SLVDCKRTAPHLAVA
S270-p AEGGLSSsCPPQssL
S275-p SSsCPPQssLFHPSE
S276-p SsCPPQssLFHPSES
S290 SPSGSRPSTPKSDSE
T291 PSGSRPSTPKSDSEL
S294 SRPSTPKSDSELVSK
S296 PSTPKSDSELVSKST
S302 DSELVSKSTERTGQK
T306 VSKSTERTGQKNPEM
S335 SPHKMKESSPLSSRK
S336 PHKMKESSPLSSRKI
S339 MKESSPLSSRKICDK
S340 KESSPLSSRKICDKS
I343 SPLSSRKICDKSHFQ
S361 SESSDTFSDQSPTLV
S364 SDTFSDQSPTLVGGA
T392 VNEEDLETLGAAAPL
L400 LGAAAPLLPMIEELK
S476 ASDNGARSANQSPQS
S480 GARSANQSPQSVGSS
S483 SANQSPQSVGSSGVD
S487 SPQSVGSSGVDSGVE
S491 VGSSGVDSGVESTSD
T521 LSDHREITKDAFLEQ
T605 SWRGRNTTIKEESKP
K607 RGRNTTIKEESKPEQ
S622 CLAGKAHSTGEQPPQ
K637 LSLATRVKHESSSSD
S640 ATRVKHESSSSDEER
S641 TRVKHESSSSDEERA
S642 RVKHESSSSDEERAA
S643 VKHESSSSDEERAAA
A655 AAAKPSNAGHLPLLP
G656 AAKPSNAGHLPLLPN
P659 PSNAGHLPLLPNVSY
S728 IDGTITRSDTLGHIL
T730 GTITRSDTLGHILPT
S755 AKLYHKVSQNGYKFL
Y759 HKVSQNGYKFLYCSA
K812 LHREVIEKKPEKFKV
S856 SYKQVGVSLNRIFTV
T908 SDFPCSDTFSNFTFW
S929 FENQDIHSASA____
S931 NQDIHSASA______
  LPIN1 iso6  
T20 LAGQVFVTVKELYKG
N48 VIRQPNGNLQCSPFH
S112 IPMHLATSPILSEGA
S130 ECQLKRGSVDRMRGL
S140 RMRGLDPSTPAQVIA
T141 MRGLDPSTPAQVIAP
T151 QVIAPSETPSSSSVV
S154 APSETPSSSSVVKKR
S156 SETPSSSSVVKKRRK
S168 RRKRRRKSQLDSLKR
S172 RRKSQLDSLKRDDNM
T181 KRDDNMNTSEDEDMF
S182 RDDNMNTSEDEDMFP
S193 DMFPIEMSSDEAMEL
S194 MFPIEMSSDEAMELL
S243 PNSDREWSPTPSSLV
T255 SLVDCKRTAPHLAVA
S270-p AEGGLSSsCPPQssL
S275-p SSsCPPQssLFHPSE
S276-p SsCPPQssLFHPSES
S290 SPSGSRPSTPKSDSE
T291 PSGSRPSTPKSDSEL
S294 SRPSTPKSDSELVSK
S296 PSTPKSDSELVSKST
S302 DSELVSKSTERTGQK
T306 VSKSTERTGQKNPEM
S335 SPHKMKESSPLSSRK
S336 PHKMKESSPLSSRKI
S339 MKESSPLSSRKICDK
S340 KESSPLSSRKICDKS
I343 SPLSSRKICDKSHFQ
S361 SESSDTFSDQSPTLV
S364 SDTFSDQSPTLVGGA
T392 VNEEDLETLGAAAPL
L400 LGAAAPLLPMIEELK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
T14 LAGQVFVTVKELYKG
S42-p VIRQPNGsLQCSPFH
S106-p IPMYLATsPILSEGA
S124-p ESQLKRNsVDRIRCL
T134 RIRCLDPTTAAQGLP
T135 IRCLDPTTAAQGLPP
T145 QGLPPSDTPSTGsLG
T148 PPSDTPSTGsLGKKR
S150-p SDTPSTGsLGKKRRK
A162 RRKRRRKAQLDNLKR
N166 RRKAQLDNLKRDDNV
S175 KRDDNVNSSEDEDMF
S176 RDDNVNSSEDEDMFP
S187-p DMFPIEMssDEDTAP
S188-p MFPIEMssDEDTAPM
S237-p PSSDREWsPSPSSLV
T249-p SLVDCQRtPPHLAEG
S261-p AEGVLSSsCPLQsCH
S266-p SSsCPLQsCHFHASE
C267 SsCPLQsCHFHASES
S281-p SPSGSRPstPKsDsE
T282-p PSGSRPstPKsDsEL
S285-p SRPstPKsDsELVSK
S287-p PstPKsDsELVSKsA
S293-p DsELVSKsADRLtPK
T298-p SKsADRLtPKNNLEM
S327 SPHKMKESsPLGsRK
S328-p PHKMKESsPLGsRKt
G331 MKESsPLGsRKtPDK
S332-p KESsPLGsRKtPDKM
T335-p sPLGsRKtPDKMNFQ
S353-p SESSDTFsDQsPTMA
S356-p SDTFsDQsPTMARGL
S384-p VNEEDLEsLGAAAPP
S392-p LGAAAPPsPVAEELK
S468-p ASDNGARsANQsPQs
S472-p GARsANQsPQsVGGs
S475-p sANQsPQsVGGsGID
S479-p sPQsVGGsGIDsGVE
S483-p VGGsGIDsGVESTSD
T513 LSDHREITKDAFLEQ
T597-p SWRGRNAtIkEESKP
K599-sm RGRNAtIkEESKPEQ
N614 CLTGKGHNTGEQPAQ
K629-sm LGLATRIkHEssssD
S632-p ATRIkHEssssDEEH
S633-p TRIkHEssssDEEHA
S634-p RIkHEssssDEEHAA
S635-p IkHEssssDEEHAAA
S647-p AAAKPSGssHLsLLS
S648-p AAKPSGssHLsLLSN
S651-p PSGssHLsLLSNVSY
S720-p IDGTITRsDtLGHIL
T722-p GTITRsDtLGHILPT
S747 AKLYHKVSQNGYKFL
Y751 HKVSQNGYKFLYCSA
K804 LHREVIEKKPEKFKV
S848-p SYKQVGVsLNRIFTV
T900-p CDFPCSDtFSNFTFW
S921-p FENQDMHsAsA____
S923-p NQDMHsAsA______
  rat

 
T14 LAGQVFVTVKELYKG
S42 VVRQPNGSLQCSPFH
S106 IPMYLATSPILSEGA
S124 ESQLKRNSVDRIRGL
T134 RIRGLDPTTAAQGLP
T135 IRGLDPTTAAQGLPP
T145 QGLPPSDTPSTGSLG
T148 PPSDTPSTGSLGKKR
S150 SDTPSTGSLGKKRRK
A162 RRKRRRKAHLDNLKR
N166 RRKAHLDNLKRDDNV
T175 KRDDNVNTSEDEDMF
S176 RDDNVNTSEDEDMFP
S187-p DMFPIEMssDEDTAL
S188-p MFPIEMssDEDTALM
S237 PNSDREWSPSPSSLV
T249 SLVDCQRTPPHLAEG
S261 AEGVLSSSCPLQSCH
S266 SSSCPLQSCHFHASE
C267 SSCPLQSCHFHASES
S281 SPSGSRPSTPKSDSE
T282 PSGSRPSTPKSDSEL
S285 SRPSTPKSDSELVSK
S287 PSTPKSDSELVSKSA
S293 DSELVSKSADRLTPK
T298 SKSADRLTPKNNLEM
S327 SPHKMKDSsPLGGRK
S328-p PHKMKDSsPLGGRKM
G331 MKDSsPLGGRKMADK
G332 KDSsPLGGRKMADKI
M335 sPLGGRKMADKIHFQ
S353 SESSDTFSDQSPTMA
S356 SDTFSDQSPTMARGL
A384 VNEEDLEALGAAAPP
L392 LGAAAPPLSVAEELK
S468 ASDNGARSANQSPQS
S472 GARSANQSPQSVGSS
S475 SANQSPQSVGSSGID
S479 SPQSVGSSGIDsGVE
S483-p VGSSGIDsGVESTSD
T513 LSDHREITKDAFLEQ
T597 SWRGRNATIKEESKP
K599 RGRNATIKEESKPEQ
N614 GLPGKGHNTGEQPAQ
K629 LGLTTRIKHESSSSD
S632 TTRIKHESSSSDEEH
S633 TRIKHESSSSDEEHS
S634 RIKHESSSSDEEHSA
S635 IKHESSSSDEEHSAT
S647 SATKPSSSSHLSLLS
S648 ATKPSSSSHLSLLSN
S651 PSSSSHLSLLSNVSY
S720 IDGTITRSDTLGHIL
T722 GTITRSDTLGHILPT
S747 AKLYHKVSQNGYKFL
Y751 HKVSQNGYKFLYCSA
K804 LHREVIEKKPEKFKV
S848 SYKQVGVSLNRIFTV
T900 CDFPCSDTFSNFTFW
S921 FENQDVHSAsA____
S923-p NQDVHSAsA______
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