Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
LPIN1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
LPIN1 Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription. Interacts with MEF2C. Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. Inhibited by N-ethylmaleimide. Belongs to the lipin family. Note: This description may include information from UniProtKB.
Protein type: Phosphatase, lipid; EC 3.1.3.4
Cellular Component: endoplasmic reticulum membrane; nuclear membrane; cytoplasm; nucleus; cytosol
Molecular Function: phosphatidate phosphatase activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphatidylcholine biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid catabolic process; triacylglycerol mobilization
Reference #:  Q14693 (UniProtKB)
Alt. Names/Synonyms: DKFZp781P1796; KIAA0188; lipin 1; Lipin-1; LPIN1; PAP1; Phosphatidate phosphatase LPIN1
Gene Symbols: LPIN1
Molecular weight: 98,664 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LPIN1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 23 T14-p LAGQVFVtVKELYKG
2 1 S106-p IPMHLATsPILSEGA
0 1 S150 SETPSSSSVVKKRRK
0 20 S162-p RRKRRRKsQLDSLKR
0 2 T175-p KRDDNMNtsEDEDMF
0 1 S176-p RDDNMNtsEDEDMFP
0 2 S187-p DMFPIEMssDEAMEL
0 2 S188-p MFPIEMssDEAMELL
1 0 S237 PNSDREWSPTPSPSG
0 1 S248 SPSGSRPStPKsDSE
0 3 T249-p PSGSRPStPKsDSEL
0 3 S252-p SRPStPKsDSELVSK
0 2 S254 PStPKsDSELVSKST
0 1 S260 DSELVSKSTERTGQK
0 2 T264 VSKSTERTGQKNPEM
0 2 S294-p PHKMKESsPLSSRKI
0 1 S319 SESSDTFSDQSPTLV
0 1 S322 SDTFSDQSPTLVGGA
0 1 L358 LGAAAPLLPMIEELK
0 3 S434-p ASDNGARsANQSPQS
1 2 S438 GARsANQSPQSVGSS
0 1 S441 sANQSPQSVGSSGVD
0 4 S449-p VGSSGVDsGVESTSD
1 0 K565 RGRNTTIKEESKPEQ
1 0 K595 LSLATRVKHESSSSD
0 2 S598 ATRVKHESSSSDEER
0 2 S599 TRVKHESSSSDEERA
0 3 S600 RVKHESSSSDEERAA
1 2 S601 VKHESSSSDEERAAA
0 1 A613 AAAKPSNAGHLPLLP
0 1 G614 AAKPSNAGHLPLLPN
0 1 S686 IDGTITRSDTLGHIL
0 1 T688 GTITRSDTLGHILPT
0 3 S887-p FENQDIHsASA____
0 2 S889 NQDIHsASA______
  mouse

 
T14 LAGQVFVTVKELYKG
S106-p IPMYLATsPILSEGA
S150-p SDTPSTGsLGKKRRK
A162 RRKRRRKAQLDNLKR
S175 KRDDNVNSSEDEDMF
S176 RDDNVNSSEDEDMFP
S187-p DMFPIEMssDEDTAP
S188-p MFPIEMssDEDTAPM
S237-p PSSDREWsPSPSSLV
S281-p SPSGSRPstPKsDsE
T282-p PSGSRPstPKsDsEL
S285-p SRPstPKsDsELVSK
S287-p PstPKsDsELVSKsA
S293-p DsELVSKsADRLtPK
T298-p SKsADRLtPKNNLEM
S328-p PHKMKESsPLGSRKT
S353-p SESSDTFsDQsPTMA
S356-p SDTFsDQsPTMARGL
S392-p LGAAAPPsPVAEELK
S468-p ASDNGARsANQsPQs
S472-p GARsANQsPQsVGGS
S475-p sANQsPQsVGGSGID
S483-p VGGSGIDsGVESTSD
K599-s RGRNATIkEESKPEQ
K629-s LGLATRIkHEssssD
S632-p ATRIkHEssssDEEH
S633-p TRIkHEssssDEEHA
S634-p RIkHEssssDEEHAA
S635-p IkHEssssDEEHAAA
S647-p AAAKPSGssHLSLLS
S648-p AAKPSGssHLSLLSN
S720-p IDGTITRsDtLGHIL
T722-p GTITRsDtLGHILPT
S921-p FENQDMHsAsA____
S923-p NQDMHsAsA______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.