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LPIN1 (human)

Overview LPIN1 Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription. Interacts with MEF2C. Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. Inhibited by N-ethylmaleimide. Belongs to the lipin family. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.4; Phosphatase, lipid Cellular Component: endoplasmic reticulum membrane; transcription factor complex; nuclear membrane; cytoplasm; nucleus; cytosol Molecular Function: peroxisome proliferator activated receptor binding; phosphatidate phosphatase activity; histone deacetylase binding; transcription coactivator activity Biological Process: mitochondrial fission; organ regeneration; transcription, DNA-dependent; regulation of fat cell differentiation; phosphatidylethanolamine biosynthetic process; glycerophospholipid biosynthetic process; triacylglycerol biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; fatty acid catabolic process; positive regulation of histone deacetylation; cellular response to insulin stimulus; phospholipid metabolic process; actin cytoskeleton reorganization; phosphatidylcholine biosynthetic process; ruffle organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; triacylglycerol mobilization Reference #:  Q14693 (UniProtKB) Alt. Names/Synonyms: DKFZp781P1796; KIAA0188; lipin 1; Lipin-1; LPIN1; PAP1; Phosphatidate phosphatase LPIN1 Gene Symbols: LPIN1 Molecular weight: 98,664 Da Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below LPIN1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 268200 605518  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	23		T14-p	LAGQVFVtVKELYKG
2	1		S106	IPMHLATSPILSEGA
0	1		T135-p	MRGLDPStPAQVIAP
0	1		S150	SETPSSSSVVKKRRK
0	20		S162-p	RRKRRRKsQLDsLKR
0	1		S166-p	RRKsQLDsLKRDDNM
0	1		T175-p	KRDDNMNtSEDEDMF
0	1		S187	DMFPIEMSSDEAMEL
0	1		S188	MFPIEMSSDEAMELL
1	0		S237	PNSDREWSPTPSPSG
0	1		-	gap
0	1		S248	SPSGSRPStPKsDSE
0	3		T249-p	PSGSRPStPKsDSEL
0	3		S252-p	SRPStPKsDSELVSK
0	2		S254	PStPKsDSELVSKST
0	1		S260	DSELVSKSTERTGQK
0	2		T264	VSKSTERTGQKNPEM
0	2		S294-p	PHKMKESsPLSSRKI
0	1		S319	SESSDTFSDQSPTLV
0	1		S322	SDTFSDQSPTLVGGA
0	1		L358	LGAAAPLLPMIEELK
0	2		S434-p	ASDNGARsANQSPQS
1	2		S438	GARsANQSPQSVGSS
0	1		S441	sANQSPQSVGSSGVD
0	1		S449	VGSSGVDSGVESTSD
0	1		T479-p	LSDHREItKDAFLEQ
0	1		T563-p	SWRGRNTtIKEESKP
1	0		K565	RGRNTtIKEESKPEQ
1	0		K595	LSLATRVKHESSSSD
0	2		S598	ATRVKHESSSSDEER
0	2		S599	TRVKHESSSSDEERA
0	3		S600	RVKHESSSSDEERAA
1	2		S601	VKHESSSSDEERAAA
0	1		A613	AAAKPSNAGHLPLLP
0	1		G614	AAKPSNAGHLPLLPN
0	1		S686	IDGTITRSDTLGHIL
0	1		T688	GTITRSDTLGHILPT
0	1		S713-p	AKLYHKVsQNGyKFL
0	1		Y717-p	HKVsQNGyKFLYCSA
0	1		K770-u	LHREVIEkKPEKFKV
0	1		S887	FENQDIHSASA____
0	1		S889	NQDIHSASA______

	mouse
T14	LAGQVFVTVKELYKG
S106-p	IPMYLATsPILSEGA
T135	IRCLDPTTAAQGLPP
S150-p	SDTPSTGsLGKKRRK
A162	RRKRRRKAQLDNLKR
N166	RRKAQLDNLKRDDNV
S175	KRDDNVNSSEDEDMF
S187-p	DMFPIEMssDEDTAP
S188-p	MFPIEMssDEDTAPM
S237-p	PSSDREWsPSPSSLV
S266-p	SSSCPLQsCHFHASE
S281-p	SPSGSRPstPKsDsE
T282-p	PSGSRPstPKsDsEL
S285-p	SRPstPKsDsELVSK
S287-p	PstPKsDsELVSKsA
S293-p	DsELVSKsADRLtPK
T298-p	SKsADRLtPKNNLEM
S328-p	PHKMKESsPLGSRKT
S353-p	SESSDTFsDQsPTMA
S356-p	SDTFsDQsPTMARGL
S392-p	LGAAAPPsPVAEELK
S468-p	ASDNGARsANQsPQs
S472-p	GARsANQsPQsVGGS
S475-p	sANQsPQsVGGSGID
S483-p	VGGSGIDsGVESTSD
T513	LSDHREITKDAFLEQ
T597	SWRGRNATIkEESKP
K599-s	RGRNATIkEESKPEQ
K629-s	LGLATRIkHEssssD
S632-p	ATRIkHEssssDEEH
S633-p	TRIkHEssssDEEHA
S634-p	RIkHEssssDEEHAA
S635-p	IkHEssssDEEHAAA
S647-p	AAAKPSGssHLSLLS
S648-p	AAKPSGssHLSLLSN
S720-p	IDGTITRsDtLGHIL
T722-p	GTITRsDtLGHILPT
S747	AKLYHKVSQNGYKFL
Y751	HKVSQNGYKFLYCSA
K804	LHREVIEKKPEKFKV
S921-p	FENQDMHsAsA____
S923-p	NQDMHsAsA______

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