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Protein Page:
MKK7 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MKK7 a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; STE group; STE7 family
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein C-terminus binding; metal ion binding; magnesium ion binding; nucleotide binding; mitogen-activated protein kinase kinase kinase binding; JUN kinase kinase activity; protein phosphatase binding; protein kinase binding; protein kinase activity; transferase activity; MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding
Biological Process: apoptosis; positive regulation of neuron apoptosis; stress-activated MAPK cascade; JNK cascade; response to stress; positive regulation of protein amino acid phosphorylation; phosphorylation; protein amino acid phosphorylation; activation of JNK activity
Reference #:  Q8CE90 (UniProtKB)
Alt. Names/Synonyms: 5930412N11Rik; c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; Jnkk2; MAP kinase kinase 7; Map2k7; MAPK/ERK kinase 7; MAPKK 7; MEK 7; mitogen activated protein kinase kinase 7; mitogen-activated protein kinase kinase 7; Mkk7; MP2K7; OTTMUSP00000017733; OTTMUSP00000017734; Prkmk7; protein kinase, mitogen activated, kinase 7; sek2
Gene Symbols: Map2k7
Molecular weight: 59,312 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Parkinson's Disease  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MKK7

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K9-u AASSLEQkLSRLEAK
0 1 S35 IDLNLDISPQRPRPI
0 1 S77-p RSPSSESsPQHPtPP
0 2 T82-p ESsPQHPtPPTRPRH
0 14 T99 GLPSTLFTPRSMESI
0 1 S102 STLFTPRSMESIEID
0 1 S105 FTPRSMESIEIDQKL
0 1 K111 ESIEIDQKLQEIMKQ
0 1 K261 GVIHRDVKPSNILLD
2 0 S287-p ISGRLVDsKAKtRSA
2 1 T291-p LVDsKAKtRSAGCAA
0 1 K342-u QFPYKNCkTDFEVLT
0 1 K389 RKRPKYNKLLEHSFI
0 1 S427 PRTSGVLSQHHLPFF
0 1 S464-p RCRGRVPsPRRATGG
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
  human

 
K9 AASSLEQKLSRLEAK
S35-p IDLNLDIsPQRPRPT
S61-p RSPSSESsPQHPtPP
T66-p ESsPQHPtPPARPRH
T83-p GLPSTLFtPRsMEsI
S86-p STLFtPRsMEsIEID
S89-p FtPRsMEsIEIDQkL
K95-u EsIEIDQkLQEIMKQ
K245-u GVIHRDVkPSNILLD
S271-p ISGRLVDsKAKtRSA
T275-p LVDsKAKtRSAGCAA
K326 QFPYKNCKTDFEVLT
K373-u RKRPKYNkLLEHSFI
S411-p PRTSGVLsQPHLPFF
- gap
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
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