a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 126.96.36.199; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein C-terminus binding; metal ion binding; nucleotide binding; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; JUN kinase kinase activity; protein kinase binding; protein phosphatase binding; protein kinase activity; MAP kinase kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding
Biological Process: apoptosis; positive regulation of neuron apoptosis; stress-activated MAPK cascade; JNK cascade; response to stress; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; phosphorylation; activation of JNK activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.