a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, dual-specificity (non-receptor); EC 22.214.171.124; Protein kinase, STE; STE group; STE7 family
Molecular Function: protein C-terminus binding; metal ion binding; nucleotide binding; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; JUN kinase kinase activity; protein kinase binding; protein phosphatase binding; protein kinase activity; transferase activity; MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; enzyme binding; protein-tyrosine kinase activity; kinase activity; ATP binding
Biological Process: apoptosis; stress-activated MAPK cascade; response to osmotic stress; protein amino acid phosphorylation; activation of JNK activity; response to heat; positive regulation of neuron apoptosis; response to wounding; JNK cascade; response to stress; positive regulation of protein amino acid phosphorylation; phosphorylation; response to UV
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.