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Protein Page:
NCBP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NCBP1 mediates U snRNA export from the nucleus. Binds to 5' capped mRNA. Found in aU snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX. Heterodimer with NCBP2. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2. Note: This description may include information from UniProtKB.
Protein type: Translation; Spliceosome; RNA processing
Cellular Component: nucleoplasm; mRNA cap complex; mitochondrion; cytoplasm; nucleolus; plasma membrane; ribonucleoprotein complex; cytosol; nucleus
Molecular Function: protein binding; RNA binding; RNA cap binding
Biological Process: transcription from RNA polymerase II promoter; spliceosomal snRNP biogenesis; viral reproduction; positive regulation of viral transcription; RNA splicing; positive regulation of mRNA 3'-end processing; histone mRNA metabolic process; mRNA metabolic process; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; mRNA capping; RNA metabolic process; RNA elongation from RNA polymerase II promoter; mRNA catabolic process, nonsense-mediated decay; gene expression; RNA-mediated gene silencing; nuclear mRNA cis splicing, via U2-type spliceosome; mRNA 3'-end processing; termination of RNA polymerase II transcription; regulation of translational initiation; mRNA cleavage
Reference #:  Q09161 (UniProtKB)
Alt. Names/Synonyms: 80 kDa nuclear cap-binding protein; CBP80; MGC2087; NCBP; NCBP 80 kDa subunit; NCBP1; nuclear cap binding protein subunit 1, 80kDa; Nuclear cap-binding protein subunit 1; Sto1
Gene Symbols: NCBP1
Molecular weight: 91,839 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NCBP1

Protein Structure Not Found.


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Sites Implicated In
RNA splicing, altered: S7‑p, T21‑p, S22‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 13 S7-p _MSRRRHsDENDGGQ
1 77 T21-p QPHKRRKtsDANEtE
1 41 S22-p PHKRRKtsDANEtED
0 7 T27-p KtsDANEtEDHLEsL
0 2 S33-p EtEDHLEsLICKVGE
0 1 K117-u RQLKESLkANNYNEA
0 1 S201-p RIFANTEsYLkRRQK
0 1 K204-a ANTEsYLkRRQKTHV
0 1 K204-u ANTEsYLkRRQKTHV
0 1 S306-p EGPVMPGsHSVERFV
0 4 S674-p ARQHKRRsDDDDRSS
0 4 K698-a QIERLQEkVESAQSE
  mouse

 
S7-p _MSRRRHsYENDGGQ
T21-p QPHKRRKtsDANEtE
S22-p PHKRRKtsDANEtED
T27-p KtsDANEtEDHLEsL
S33-p EtEDHLEsLICKVGE
K117 RQLKESLKANNYNEA
S201 RIFSTTESYLKRRQK
K204 STTESYLKRRQKTHV
K204 STTESYLKRRQKTHV
S306 EGPVMPGSHSVERFV
S674-p ARQHKRRsDDDDRSS
K698 QIERLQEKVEAAQSE
  rat

 
S7 _MSRRRHSYENDGGQ
T21-p QPHKRRKtsDANETE
S22-p PHKRRKtsDANETED
T27 KtsDANETEDHLESL
S33 ETEDHLESLICKVGE
K117 RQLKESLKANNYNEA
S201 RIFSSTESYLKRRQK
K204 SSTESYLKRRQKTHV
K204 SSTESYLKRRQKTHV
S306 EGPVMPGSHSVERFV
S674 ARQHKRRSDDDDRGS
K698 QIERLQEKVESAQSE
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