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Protein Page:
WDR77 (human)

Overview
WDR77 a WD40 repeat protein. Component of the methylosome, a 20S complex containing at least ICLN, SKB1 and WDR77. Interacts with SKB1 and with SM proteins. The methylosome may regulate an early step in the assembly of U snRNPs, possibly the transfer of Sm proteins to the SMN-complex. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Adaptor/scaffold
Cellular Component: Golgi apparatus; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity
Biological Process: regulation of transcription from RNA polymerase II promoter; spliceosomal snRNP biogenesis; RNA metabolic process; positive regulation of cell proliferation; gene expression
Reference #:  Q9BQA1 (UniProtKB)
Alt. Names/Synonyms: Androgen receptor cofactor p44; HKMT1069; MEP-50; MEP50; Methylosome protein 50; MGC2722; Nbla10071; p44; p44/Mep50; RP11-552M11.3; WD repeat domain 77; WD repeat-containing protein 77; WDR77
Gene Symbols: WDR77
Molecular weight: 36,724 Da
Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WDR77

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, altered: T5‑p, S264‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 90 T5-p ___MRKEtPPPLVPP
0 1 S38-p LEAARYRsDGALLLG
0 1 S47-p GALLLGAsSLSGRCW
0 1 S181-p AASPHKDsVFLSCSE
1 1 S264-p CVTGLVFsPHSVPFL
1 0 S306-p FVRDATWsPLNHSLL
  mouse

 
T5-p ___MRKDtPPPLVPP
S38 LEAARYRSDGSLLLG
S47 GSLLLGVSSLSGRCW
S181 AASPHKDSVFLSCSE
S264 GVTRLVFSPHSVPLL
S306 FVRDATWSPLNHSLL
  rat

 
S5-p ___MRKEsPPPLVPP
S38 LEAARYRSDGSLLLG
S47 GSLLLGASSLSGRCW
T181 AASPHRETVFLSCSE
S264 CVTRLVFSPHSVPFL
S306 FVRDATWSPLNHSLL
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