Home

WDR77 (human)

Overview WDR77 a WD40 repeat protein. Component of the methylosome, a 20S complex containing at least ICLN, SKB1 and WDR77. Interacts with SKB1 and with SM proteins. The methylosome may regulate an early step in the assembly of U snRNPs, possibly the transfer of Sm proteins to the SMN-complex. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Cellular Component: Golgi apparatus; cytoplasm; nucleolus; cytosol; nucleus Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity Biological Process: regulation of transcription from RNA polymerase II promoter; spliceosomal snRNP biogenesis; RNA metabolic process; positive regulation of cell proliferation; gene expression Reference #:  Q9BQA1 (UniProtKB) Alt. Names/Synonyms: Androgen receptor cofactor p44; HKMT1069; MEP-50; MEP50; Methylosome protein 50; MGC2722; Nbla10071; p44; p44/Mep50; RP11-552M11.3; WD repeat domain 77; WD repeat-containing protein 77; WDR77 Gene Symbols: WDR77 Molecular weight: 36,724 Da Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below WDR77 4GQB - A=1-637 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  DISEASE  |  NURSA  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
carcinogenesis, altered: T5‑p, S264‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	70		T5-p	___MRKEtPPPLVPP
0	1		S181-p	AASPHKDsVFLSCSE
1	1		S264-p	CVTGLVFsPHSVPFL
1	0		S306-p	FVRDATWsPLNHSLL

	mouse
T5-p	___MRKDtPPPLVPP
S181	AASPHKDSVFLSCSE
S264	GVTRLVFSPHSVPLL
S306	FVRDATWSPLNHSLL

	rat
S5-p	___MRKEsPPPLVPP
T181	AASPHRETVFLSCSE
S264	CVTRLVFSPHSVPFL
S306	FVRDATWSPLNHSLL

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.