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NCOA4 (human)

Overview NCOA4 Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Defects in NCOA4 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Nuclear receptor co-regulator Cellular Component: nucleus Molecular Function: androgen receptor binding; transcription coactivator activity Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; male gonad development; androgen receptor signaling pathway Reference #:  Q13772 (UniProtKB) Alt. Names/Synonyms: 70 kDa androgen receptor coactivator; 70 kDa AR-activator; Androgen receptor coactivator 70 kDa protein; androgen receptor coactivator, 70-kD; Androgen receptor-associated protein of 70 kDa; ARA70; DKFZp762E1112; ELE1; NCoA-4; NCOA4; Nuclear receptor coactivator 4; papillary thyroid carcinoma 3; PTC3; ret fused; RET-activating gene ELE1; Ret-activating protein ELE1; RFG Gene Symbols: NCOA4 Molecular weight: 69,726 Da Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states

Select Structure to View Below NCOA4 1T5Z - B=322-336 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE 188550 601984  |  NURSA  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K42-u	LRAEQQIkDNLREVK
0	1		S57-p	AQIHSCIsRHLECLR
0	1		K181-u	NIGPFLEkRGCISMP
0	1		S194-p	MPEQKSAsGIVAVPF
0	1		S212-p	LLGSKPAsGYQAPYI
0	1		S237-p	QKQTLENsQTssRAC
0	1		S240-p	TLENsQTssRACNFF
0	1		S241-p	LENsQTssRACNFFN
0	3		N245	QTssRACNFFNNVGG
0	3		N248	sRACNFFNNVGGNLk
0	1		K255-u	NNVGGNLkGLENWLL
0	1		K263-u	GLENWLLkSEKSSYQ
0	1		K313-u	VTPQESHkLRKPENG
0	1		S334-p	KFKLLFQsYNVNDWL
0	1		K367-u	IENLGNLkCLNDHLE
0	2		K424-u	VCDENCEkEALYkWL
0	1		K429-u	CEkEALYkWLLKKEG
0	1		S456-p	EPEKHKDsLNMWLCP
0	1		K472-u	KEVIEQTkAPKAMTP
0	1		S485	TPSRIADSFQVIkNS
0	1		K490-u	ADSFQVIkNSPLSEW
0	1		K509-u	PYKEGSPkEVPGTED
0	2		N548	LPGKKMGNLSQLSSG
0	2		S554	GNLSQLSSGEDkWLL
0	1		K558-u	QLSSGEDkWLLRKKA
0	1		S572	AQEVLLNSPLQEEHN

	mouse
K42	LRAEQQIKDNLREVK
S57	AQIHSCISRHLECLR
K181	SIGPFLEKRGYIQVP
S194	VPEQKSASSGTAVSL
I212	LLVSKPAIGLQAPYV
S237	PKQTSENSQTSARAC
S240	TSENSQTSARACsFF
A241	SENSQTSARACsFFs
S245-p	QTSARACsFFsDAWG
S248-p	ARACsFFsDAWGNLK
K255	sDAWGNLKGLENWLL
-	under review
E319	VTPQEPCELEKPVDG
P344	LFQVFREPYSVSDWL
K377	IENLGNLKCLNDHLE
K435	VCDDNCEKEAMYKWL
K440	CEKEAMYKWLLKKGG
S467	EPEKHRESLTLWLCP
K484	NELTEQAKAPKAMAP
S497-p	APARIADsFHVIKNS
K502	ADsFHVIKNSSLSEW
K520-u	PTCKGGPkDVPNTEE
S559-p	LPGKKVGsLSQFPsG
S565-p	GsLSQFPsGEDKWLL
K569	QFPsGEDKWLLRKKA
S583-p	AQEAFLNsPLQEERN

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