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Protein Page:
NCOA4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NCOA4 Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Defects in NCOA4 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: nucleus
Molecular Function: androgen receptor binding; transcription coactivator activity
Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; male gonad development; androgen receptor signaling pathway; response to hormone stimulus
Reference #:  Q13772 (UniProtKB)
Alt. Names/Synonyms: 70 kDa androgen receptor coactivator; 70 kDa AR-activator; Androgen receptor coactivator 70 kDa protein; androgen receptor coactivator, 70-kD; Androgen receptor-associated protein of 70 kDa; ARA70; DKFZp762E1112; ELE1; NCoA-4; NCOA4; Nuclear receptor coactivator 4; papillary thyroid carcinoma 3; PTC3; ret fused; RET-activating gene ELE1; Ret-activating protein ELE1; RFG
Gene Symbols: NCOA4
Molecular weight: 69,726 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below

NCOA4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K42-ub LRAEQQIkDNLREVK
0 1 S57-p AQIHSCIsRHLECLR
0 1 K181-ub NIGPFLEkRGCIsMP
0 2 S186-p LEkRGCIsMPEQKSA
0 1 S194-p MPEQKSAsGIVAVPF
0 1 S212-p LLGSKPAsGYQAPYI
0 1 S237-p QKQTLENsQTssRAC
0 1 S240-p TLENsQTssRACNFF
0 1 S241-p LENsQTssRACNFFN
0 4 N245 QTssRACNFFNNVGG
0 4 N248 sRACNFFNNVGGNLk
0 1 K255-ub NNVGGNLkGLENWLL
0 1 K263-ub GLENWLLkSEKSSYQ
0 1 T307-p DLSDWLVtPQESHkL
0 1 K313-ub VtPQESHkLRKPENG
0 1 S334-p KFKLLFQsYNVNDWL
0 1 K367-ub IENLGNLkCLNDHLE
0 2 K424-ub VCDENCEkEALYkWL
0 1 K429-ub CEkEALYkWLLKKEG
0 1 S456-p EPEKHKDsLNMWLCP
0 1 K472-ub KEVIEQTkAPKAMTP
0 1 S485 TPSRIADSFQVIkNs
0 1 K490-ub ADSFQVIkNsPLSEW
0 1 S492-p SFQVIkNsPLSEWLI
0 1 P493 FQVIkNsPLSEWLIR
0 1 S507-p RPPYKEGsPKEVPGT
0 1 K509 PYKEGsPKEVPGTED
0 2 N548 LPGKKMGNLSQLSsG
0 3 S554-p GNLSQLSsGEDkWLL
0 1 K558-ub QLSsGEDkWLLRKKA
0 1 S572 AQEVLLNSPLQEEHN
  mouse

 
K42 LRAEQQIKDNLREVK
S57 AQIHSCISRHLECLR
K181 SIGPFLEKRGYIQVP
Q186 LEKRGYIQVPEQKSA
S194 VPEQKSASSGTAVSL
I212 LLVSKPAIGLQAPYV
S237 PKQTSENSQTSARAC
S240 TSENSQTSARACsFF
A241 SENSQTSARACsFFs
S245-p QTSARACsFFsDAWG
S248-p ARACsFFsDAWGNLK
K255 sDAWGNLKGLENWLL
N263 GLENWLLNSHQQEIA
T313 DLSDWLVTPQEPCEL
E319 VTPQEPCELEKPVDG
P344 LFQVFREPYSVSDWL
K377 IENLGNLKCLNDHLE
K435 VCDDNCEKEAMYKWL
K440 CEKEAMYKWLLKKGG
S467 EPEKHRESLTLWLCP
K484 NELTEQAKAPKAMAP
S497-p APARIADsFHVIKNS
K502 ADsFHVIKNSsLSEW
S504 sFHVIKNSsLSEWLM
S505-p FHVIKNSsLSEWLMG
G518 MGPTCKGGPkDVPNT
K520-ub PTCKGGPkDVPNTEE
S559-p LPGKKVGsLSQFPsG
S565-p GsLSQFPsGEDKWLL
K569 QFPsGEDKWLLRKKA
S583-p AQEAFLNsPLQEERN
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