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eIF3S3 (human)

Overview eIF3S3 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination- dependent manner. Belongs to the eIF-3 subunit H family. Note: This description may include information from UniProtKB. Protein type: Translation; Translation initiation Cellular Component: eukaryotic translation initiation factor 3 complex; cytoplasm; cytosol Molecular Function: protein binding; translation initiation factor activity Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression; regulation of translational initiation Reference #:  O15372 (UniProtKB) Alt. Names/Synonyms: eIF-3-gamma; eIF3 p40 subunit; eIF3-gamma; eIF3-p40; EIF3H; EIF3S3; Eukaryotic translation initiation factor 3 subunit 3; Eukaryotic translation initiation factor 3 subunit H; eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD); eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD); eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa; eukaryotic translation initiation factor 3, subunit H; MGC102958 Gene Symbols: EIF3H Molecular weight: 39,930 Da Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states CST Pathways:  Translational Control Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below eIF3S3

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	Sites Implicated In
cell growth, altered: S183‑p activation: S183‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	8		K5-u	___MASRkEGtGSTA
0	1		T8-p	MASRkEGtGSTATSS
0	1		S17-p	STATSSSsTAGAAGk
0	2		K24-a	sTAGAAGkGkGkGGs
0	3		K24-u	sTAGAAGkGkGkGGs
0	2		K26-a	AGAAGkGkGkGGsGD
0	1		K28-u	AAGkGkGkGGsGDSA
0	1		S31-p	kGkGkGGsGDSAVkQ
0	1		K37-u	GsGDSAVkQVQIDGL
0	1		K156-u	VLIYDPIkTAQGSLs
0	1		S163-p	kTAQGSLsLkAYRLT
0	1		K165-u	AQGSLsLkAYRLTPK
1	10		S183-p	VCKEKDFsPEALkKA
0	2		K188-u	DFsPEALkKANITFE
0	1		N191	PEALkKANITFEYMF
0	1		K220-u	VLMWELEkKSAVADk
0	3		K227-u	kKSAVADkHELLSLA
0	1		K241-u	ASSNHLGkNLQLLMD
0	3		K259-u	EMSQDIVkYNTyMRN
0	1		Y263-p	DIVkYNTyMRNTSKQ
0	1		K274-u	TSKQQQQkHQYQQRR
0	2		K303-u	LPEEDLSkLFkPPQP
0	7		K306-u	EDLSkLFkPPQPPAR
0	1		S316-p	QPPARMDsLLIAGQI
0	3		K331-u	NTYCQNIkEFTAQNL
0	1		K340-u	FTAQNLGkLFMAQAL

	mouse
K5	___MASRKEGTGSTA
T8	MASRKEGTGSTATSS
S17	STATSSGSAGGAVGk
K24-a	SAGGAVGkGkGKGGS
K24	SAGGAVGKGkGKGGS
K26-a	GGAVGkGkGKGGSGD
K28	AVGkGkGKGGSGDSA
S31	kGkGKGGSGDSAVKQ
K37	GSGDSAVKQVQIDGL
K156	VLIYDPIKTAQGSLS
S163	KTAQGSLSLKAYRLT
K165	AQGSLSLKAYRLTPK
S183-p	VCKEKDFsPEALkKA
K188-u	DFsPEALkKAsITFE
S191-p	PEALkKAsITFEHMF
K220	VLMWELEKKSAVADk
K227-u	KKSAVADkHELLSLA
K241	ASSNHLGKSLQLLMD
K259-u	EMSQDIIkYNTYMRN
Y263	DIIkYNTYMRNTSKQ
K274	TSKQQQQKHQYQQRR
K303-u	LPEEDLSkLFkPHQA
K306-u	EDLSkLFkPHQAPAR
S316	QAPARMDSLLIAGQI
K331	NTYCQNIKEFTAQNL
K340	FTAQNLGKLFMAQAL

	rat
K5	___MASRKEGTGSTA
T8	MASRKEGTGSTATSS
S17	STATSSSSTGGAVGK
K24	STGGAVGKGKGKGGS
K24	STGGAVGKGKGKGGS
K26	GGAVGKGKGKGGSGD
K28	AVGKGKGKGGSGDSA
S31	KGKGKGGSGDSAVKQ
K37	GSGDSAVKQVQIDGL
K156	VLIYDPIKTAQGSLS
S163	KTAQGSLSLKAYRLT
K165	AQGSLSLKAYRLTPK
S183	VCKEKDFSPEALKKA
K188	DFSPEALKKANITFE
N191	PEALKKANITFEHMF
K220	VLMWELEKKSAVADK
K227	KKSAVADKHELLSLA
K241	ASSNHLGKNLQLLMD
K259	EMSQDIIKYNTYMRN
Y263	DIIKYNTYMRNSSKQ
K274	SSKQQQQKHQYQQRR
K303	LPEEDLSKLFkPHQA
K306-u	EDLSKLFkPHQAPAR
S316	QAPARMDSLLIAGQI
K331	NTYCQNIKEFTAQNL
K340	FTAQNLGKLFMAQAL

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