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Protein Page:
MLLT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MLLT1 a transcriptional regulator that can activate transcription from synthetic reporter genes in both lymphoid and myeloid cells. A chromosomal aberration involving MLLT1 is associated with acute leukemias. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; negative regulation of protein kinase activity
Reference #:  Q03111 (UniProtKB)
Alt. Names/Synonyms: ENL; ENL/MLL fusion partner; LTG19; MLLT1; MLLT1/MLL fusion partner; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); Protein ENL; translocated to, 1; YEATS domain-containing protein 1; YEATS1
Gene Symbols: MLLT1
Molecular weight: 62,056 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MLLT1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y78 YKVEESGYAGFIMPI
0 3 H88 FIMPIEVHFKNKEEP
0 3 S155-p ADTVSRPsPDyPMLP
0 2 Y158-p VSRPsPDyPMLPtIP
0 1 T163-p PDyPMLPtIPLsAFs
0 1 S167-p MLPtIPLsAFsDPKK
0 1 S170-p tIPLsAFsDPKKTKP
0 36 S209-p RERPRKDsESKSSSK
0 8 K252-ac PPPKAAFkEPKMALK
0 1 S265-p LKETKLEsTsPKGGP
0 6 S267-p ETKLEsTsPKGGPPP
0 1 S283-p PPPPPRAssKRPAtA
0 1 S284-p PPPPRAssKRPAtAD
0 1 T289-p AssKRPAtADsPKPs
0 14 S292-p KRPAtADsPKPsAkK
0 4 S296-p tADsPKPsAkKQKKS
0 8 K298-ac DsPKPsAkKQKKSSS
0 1 K299 sPKPsAkKQKKSSSK
0 1 K301 KPsAkKQKKSSSKGS
0 1 S310-p SSSKGSRsAPGTsPR
0 1 S315-p SRsAPGTsPRTSSSS
0 1 K327-ac SSSSFSDkKPAKDKS
0 15 S359-p KALEVEEsNsEDEAs
0 14 S361-p LEVEEsNsEDEAsFK
0 1 S366-p sNsEDEAsFKSESAQ
0 1 S414-p EDLQSEEsDEDDsss
0 1 S419-p EEsDEDDsssGEEAA
0 1 S420-p EsDEDDsssGEEAAG
0 1 S421-p sDEDDsssGEEAAGK
0 16 S475-p SKVSGRRsPEsCsKP
0 2 S478-p SGRRsPEsCsKPEKI
0 1 S480-p RRsPEsCsKPEKILK
0 1 T490-p EKILKKGtyDKAYTD
0 1 Y491-p KILKKGtyDKAYTDE
  mouse

 
Y78 YKVEESGYAGFIMLI
Y88 FIMLIEVYFKNKEEP
S155 ADTVSRPSPDYPMLP
Y158 VSRPSPDYPMLPTIP
T163 PDYPMLPTIPLSAFS
S167 MLPTIPLSAFSDPKK
S170 TIPLSAFSDPKKNKP
S209-p RERPRKDsESRSCSK
K246-ac PVPKAAFkEPKMALK
S259 LKETKLESLsPKGVP
S261-p ETKLESLsPKGVPQP
S275 PPTLPKASSKRPAAT
S276 PTLPKASSKRPAATD
A281 ASSKRPAATDsPKLS
S284-p KRPAATDsPKLSAKk
S288 ATDsPKLSAKkPkKS
K290 DsPKLSAKkPkKSGS
K291-ac sPKLSAKkPkKSGSK
K293-ac KLSAKkPkKSGSKGT
R302 SGSKGTRRAPGTsPR
S307-p TRRAPGTsPRASSFP
K316 RASSFPDKKVARDKN
S347-p RTLQTEDsNsEDEAS
S349-p LQTEDsNsEDEASFR
S354 sNsEDEASFRSESAQ
S402 EDLQSEGSDEDDSSS
S407 EGSDEDDSSSGEENT
S408 GSDEDDSSSGEENTR
S409 SDEDDSSSGEENTRK
S463-p SKVSGRRsPEPCSKP
P466 SGRRsPEPCSKPEKM
S468 RRsPEPCSKPEKMLK
T478 EKMLKKATYDKAYTD
Y479 KMLKKATYDKAYTDE
  rat

 
Y78-p YKVEESGyAGFIMLI
Y88-p FIMLIEVyFKNKEEP
S155 ADTVSRPSPDYPMLP
Y158 VSRPSPDYPMLPTIP
T163 PDYPMLPTIPLSAFS
S167 MLPTIPLSAFSDPKK
S170 TIPLSAFSDPKKNKP
S209 RERPRKDSESRSCSK
K246 PVPKAAFKEPKMALK
S259 LKETKLESLSPKGVS
S261 ETKLESLSPKGVSQP
S275 PPTLPKASSKRPAAT
S276 PTLPKASSKRPAATD
A281 ASSKRPAATDSPKPS
S284 KRPAATDSPKPSAKK
S288 ATDSPKPSAKKPKKS
K290 DSPKPSAKKPKKSGS
K291 SPKPSAKKPKKSGSK
K293 KPSAKKPKKSGSKGA
R302 SGSKGARRAPGTSPR
S307 ARRAPGTSPRASSFP
K316 RASSFPDKKVARDKS
S347-p RTLQAEDsNsEDEAS
S349-p LQAEDsNsEDEASFR
S354 sNsEDEASFRSESAQ
S402 EDLQSEGSDEDDSSS
S407 EGSDEDDSSSGEEST
S408 GSDEDDSSSGEESTV
S409 SDEDDSSSGEESTVK
S463 SKVTGRRSPEPCSKP
P466 TGRRSPEPCSKPEKI
S468 RRSPEPCSKPEKILK
T478 EKILKKATYDKAYTD
Y479 KILKKATYDKAYTDE
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