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MLLT1 (human)

Overview MLLT1 a transcriptional regulator that can activate transcription from synthetic reporter genes in both lymphoid and myeloid cells. A chromosomal aberration involving MLLT1 is associated with acute leukemias. Note: This description may include information from UniProtKB. Protein type: Transcription regulation Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function: protein binding; DNA binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; negative regulation of protein kinase activity Reference #:  Q03111 (UniProtKB) Alt. Names/Synonyms: ENL; ENL/MLL fusion partner; LTG19; MLLT1; MLLT1/MLL fusion partner; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); Protein ENL; translocated to, 1; YEATS domain-containing protein 1; YEATS1 Gene Symbols: MLLT1 Molecular weight: 62,056 Da Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MLLT1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		Y78	YKVEESGYAGFIMPI
0	3		H88	FIMPIEVHFKNKEEP
0	3		S155-p	ADTVSRPsPDyPMLP
0	2		Y158-p	VSRPsPDyPMLPtIP
0	1		T163-p	PDyPMLPtIPLsAFs
0	1		S167-p	MLPtIPLsAFsDPKK
0	1		S170-p	tIPLsAFsDPKKTKP
0	36		S209-p	RERPRKDsESKSSSK
0	8		K252-a	PPPKAAFkEPKMALK
0	4		S267-p	ETKLESTsPKGGPPP
0	1		S283-p	PPPPPRAssKRPAtA
0	1		S284-p	PPPPRAssKRPAtAD
0	1		T289-p	AssKRPAtADsPKPs
0	11		S292-p	KRPAtADsPKPsAkK
0	4		S296-p	tADsPKPsAkKQKKS
0	8		K298-a	DsPKPsAkKQKKSSS
0	1		K299	sPKPsAkKQKKSSSK
0	1		K301	KPsAkKQKKSSSKGS
0	1		S310-p	SSSKGSRsAPGTsPR
0	1		S315-p	SRsAPGTsPRTSSSS
0	10		S359-p	KALEVEEsNsEDEAs
0	10		S361-p	LEVEEsNsEDEAsFK
0	1		S366-p	sNsEDEAsFKSESAQ
0	1		S414-p	EDLQSEEsDEDDsss
0	1		S419-p	EEsDEDDsssGEEAA
0	1		S420-p	EsDEDDsssGEEAAG
0	1		S421-p	sDEDDsssGEEAAGK
0	14		S475-p	SKVSGRRsPEsCsKP
0	1		S478-p	SGRRsPEsCsKPEKI
0	1		S480-p	RRsPEsCsKPEKILK
0	1		T490-p	EKILKKGtyDKAYTD
0	1		Y491-p	KILKKGtyDKAYTDE

	mouse
Y78	YKVEESGYAGFIMLI
Y88	FIMLIEVYFKNKEEP
S155	ADTVSRPSPDYPMLP
Y158	VSRPSPDYPMLPTIP
T163	PDYPMLPTIPLSAFS
S167	MLPTIPLSAFSDPKK
S170	TIPLSAFSDPKKNKP
S209-p	RERPRKDsESRSCSK
K246-a	PVPKAAFkEPKMALK
S261-p	ETKLESLsPKGVPQP
S275	PPTLPKASSKRPAAT
S276	PTLPKASSKRPAATD
A281	ASSKRPAATDsPKLS
S284-p	KRPAATDsPKLSAKk
S288	ATDsPKLSAKkPkKS
K290	DsPKLSAKkPkKSGS
K291-a	sPKLSAKkPkKSGSK
K293-a	KLSAKkPkKSGSKGT
R302	SGSKGTRRAPGTSPR
S307	TRRAPGTSPRASSFP
S347-p	RTLQTEDsNsEDEAS
S349-p	LQTEDsNsEDEASFR
S354	sNsEDEASFRSESAQ
S402	EDLQSEGSDEDDSSS
S407	EGSDEDDSSSGEENT
S408	GSDEDDSSSGEENTR
S409	SDEDDSSSGEENTRK
S463-p	SKVSGRRsPEPCSKP
P466	SGRRsPEPCSKPEKM
S468	RRsPEPCSKPEKMLK
T478	EKMLKKATYDKAYTD
Y479	KMLKKATYDKAYTDE

	rat
Y78-p	YKVEESGyAGFIMLI
Y88-p	FIMLIEVyFKNKEEP
S155	ADTVSRPSPDYPMLP
Y158	VSRPSPDYPMLPTIP
T163	PDYPMLPTIPLSAFS
S167	MLPTIPLSAFSDPKK
S170	TIPLSAFSDPKKNKP
S209	RERPRKDSESRSCSK
K246	PVPKAAFKEPKMALK
S261	ETKLESLSPKGVSQP
S275	PPTLPKASSKRPAAT
S276	PTLPKASSKRPAATD
A281	ASSKRPAATDSPKPS
S284	KRPAATDSPKPSAKK
S288	ATDSPKPSAKKPKKS
K290	DSPKPSAKKPKKSGS
K291	SPKPSAKKPKKSGSK
K293	KPSAKKPKKSGSKGA
R302	SGSKGARRAPGTSPR
S307	ARRAPGTSPRASSFP
S347	RTLQAEDSNSEDEAS
S349	LQAEDSNSEDEASFR
S354	SNSEDEASFRSESAQ
S402	EDLQSEGSDEDDSSS
S407	EGSDEDDSSSGEEST
S408	GSDEDDSSSGEESTV
S409	SDEDDSSSGEESTVK
S463	SKVTGRRSPEPCSKP
P466	TGRRSPEPCSKPEKI
S468	RRSPEPCSKPEKILK
T478	EKILKKATYDKAYTD
Y479	KILKKATYDKAYTDE

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