Home

SLC1A1 (human)

Overview SLC1A1 Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Transporter Cellular Component: membrane; integral to plasma membrane; plasma membrane Molecular Function: glutamate binding; sodium:dicarboxylate symporter activity; glutamate:sodium symporter activity; L-glutamate transmembrane transporter activity Biological Process: synaptic transmission; L-glutamate import; ion transport; transmembrane transport; protein homooligomerization Reference #:  P43005 (UniProtKB) Alt. Names/Synonyms: EAA3; EAAC1; EAAT3; excitatory amino acid carrier 1; Excitatory amino acid transporter 3; excitatory amino acid transporter-3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; SLC1A1; Sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 member 1 Gene Symbols: SLC1A1 Molecular weight: 57,100 Da Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SLC1A1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		A5	___MGKPARKGCEWK
0	1		S45	VREHSNLSTLEKFyF
0	2		Y51-p	LSTLEKFyFAFPGEI
0	1		S193-p	AVMTTAIsKNKTKEY
0	1		K201-u	KNKTKEYkIVGMYSD
0	1		K464	FGTGIVEKLSKKELE
2	0		S466	TGIVEKLSKKELEQM
0	1		K468	IVEKLSKKELEQMDV
0	1		S476	ELEQMDVSSEVNIVN
0	1		S513-p	GGFAVDKsDtIsFtQ
0	1		T515-p	FAVDKsDtIsFtQTs
0	3		S517-p	VDKsDtIsFtQTsQF
0	1		T519-p	KsDtIsFtQTsQF__
0	2		S522-p	tIsFtQTsQF_____

	mouse
T5	___MGKPTSSGCDWR
S45	VRGHSELSNLDKFyF
Y51-p	LSNLDKFyFAFPGEI
S192	TTAMTTMSENKTKEY
K200	ENKTKEYKIVGLYSD
K463-a	FGTGIVEkLSKkELE
S465	TGIVEkLSKkELEQM
K467-u	IVEkLSKkELEQMDV
S475-p	ELEQMDVsSEVNIVN
S512	GGFAVDKSDTIsFTQ
T514	FAVDKSDTIsFTQTs
S516-p	VDKSDTIsFTQTsQF
T518	KSDTIsFTQTsQF__
S521-p	TIsFTQTsQF_____

	rat
T5-p	___MGKPtSSGCDWR
S45-p	VRGHSELsNLDKFYF
Y51	LsNLDKFYFAFPGEI
S192	TTAMTTMSENKTKEY
K200	ENKTKEYKIVGLYSD
K463	FGTGIVEKLsKKELE
S465-p	TGIVEKLsKKELEQV
K467	IVEKLsKKELEQVDV
S475	ELEQVDVSSEVNIVN
S512	GGFSVDKSDTISFTQ
T514	FSVDKSDTISFTQTS
S516	VDKSDTISFTQTSQF
T518	KSDTISFTQTSQF__
S521	TISFTQTSQF_____

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.