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Protein Page:
SLC1A1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SLC1A1 Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: membrane; integral to plasma membrane; plasma membrane
Molecular Function: glutamate binding; glutamate:sodium symporter activity; sodium:dicarboxylate symporter activity; L-glutamate transmembrane transporter activity
Biological Process: synaptic transmission; L-glutamate import; ion transport; transmembrane transport; protein homooligomerization
Reference #:  P43005 (UniProtKB)
Alt. Names/Synonyms: EAA3; EAAC1; EAAT3; excitatory amino acid carrier 1; Excitatory amino acid transporter 3; excitatory amino acid transporter-3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; SLC1A1; Sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 member 1
Gene Symbols: SLC1A1
Molecular weight: 57,100 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC1A1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 A5 ___MGKPARKGCEWK
0 1 S45 VREHSNLSTLEKFyF
0 2 Y51-p LSTLEKFyFAFPGEI
2 0 S466 TGIVEKLSKKELEQM
0 1 K468 IVEKLSKKELEQMDV
0 1 S476 ELEQMDVSSEVNIVN
0 1 S513-p GGFAVDKsDtIsFtQ
0 1 T515-p FAVDKsDtIsFtQTs
0 3 S517-p VDKsDtIsFtQTsQF
0 1 T519-p KsDtIsFtQTsQF__
0 2 S522-p tIsFtQTsQF_____
  mouse

 
T5 ___MGKPTSSGCDWR
S45 VRGHSELSNLDKFyF
Y51-p LSNLDKFyFAFPGEI
S465 TGIVEKLSKkELEQM
K467-u IVEKLSKkELEQMDV
S475-p ELEQMDVsSEVNIVN
S512 GGFAVDKSDTIsFTQ
T514 FAVDKSDTIsFTQTs
S516-p VDKSDTIsFTQTsQF
T518 KSDTIsFTQTsQF__
S521-p TIsFTQTsQF_____
  rat

 
T5-p ___MGKPtSSGCDWR
S45-p VRGHSELsNLDKFYF
Y51 LsNLDKFYFAFPGEI
S465-p TGIVEKLsKKELEQV
K467 IVEKLsKKELEQVDV
S475 ELEQVDVSSEVNIVN
S512 GGFSVDKSDTISFTQ
T514 FSVDKSDTISFTQTS
S516 VDKSDTISFTQTSQF
T518 KSDTISFTQTSQF__
S521 TISFTQTSQF_____
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