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Protein Page:
CNGB3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CNGB3 Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. Defects in CNGB3 are the cause of Stargardt disease type 1 (STGD1). STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD1 inheritance is autosomal recessive. Defects in CNGB3 are the cause of achromatopsia type 3 (ACHM3); also known as Pingelapese blindness. ACHM3 is a congenital complete achromatopsia and is distinct from total colorblindness mainly because of the consistent concurrence of severe myopia. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass
Cellular Component: photoreceptor outer segment; integral to plasma membrane
Molecular Function: voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; cGMP binding
Biological Process: phototransduction, visible light; regulation of membrane potential; visual perception; transport; signal transduction; cation transport
Reference #:  Q9NQW8 (UniProtKB)
Alt. Names/Synonyms: CNG channel beta-3; CNGB3; cone photoreceptor cGMP-gated cation channel beta-subunit; Cone photoreceptor cGMP-gated channel subunit beta; cyclic nucleotide gated channel beta 3; Cyclic nucleotide-gated cation channel beta-3; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-3
Gene Symbols: CNGB3
Molecular weight: 92,167 Da
Basal Isoelectric point: 8.06  Predict pI for various phosphorylation states
Select Structure to View Below

CNGB3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S31-p SRRNEEGsHPSNQSQ
0 1 T40-p PSNQSQQttAQEENK
0 1 T41-p SNQSQQttAQEENKG
0 2 K51-ub EENKGEEkSLKTKST
0 1 S74-p TNIQDKLsKKNSSGD
0 1 T95-p PQNAAEPtGtVPEQK
0 1 T97-p NAAEPtGtVPEQKEM
0 1 K166-ac EASPQTAkPTAVPPV
0 1 Y200-p KKMPLTEyLKRIKLP
1 0 Y545-p LRLKSVLyLPGDFVC
0 1 Y631 LQEILVHYPDSERIL
0 1 D633 EILVHYPDSERILMK
0 2 T652-p LLKQKAKtAEAtPPR
0 2 T656-p KAKtAEAtPPRKDLA
0 1 K677 EETPKLFKTLLGGTG
0 1 K714-ac EGGEEEGkENEDKQK
  mouse

 
C24 GRMEKKLCPNLSSLS
P33 NLSSLSQPTIAQGDN
T34 LSSLSQPTIAQGDNQ
- gap
T66 HSKEDNSTGENSLRD
T87 PECRAELTRTMAEME
T89 CRAELTRTMAEMEKT
M159 EASSQTAMSTNISPK
H192 QRVPVKEHLRRMILP
Y537 LRLKSTIYLPGDFVC
Y623-p LQEILLHyPtSKKLL
T625-p EILLHyPtSKKLLMK
T644 LLSQKGKTTQAIPAR
I648 KGKTTQAIPARPGPA
K669-ac EETPRMLkVLLGNTG
- gap
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