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CA9 (human)

Overview CA9 Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Forms oligomers linked by disulfide bonds. By hypoxia. Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). Belongs to the alpha-carbonic anhydrase family. Note: This description may include information from UniProtKB. Protein type: EC 4.2.1.1; Lyase; Membrane protein, integral; Energy Metabolism - nitrogen Cellular Component: microvillus membrane; nucleolus; plasma membrane; integral to membrane Molecular Function: carbonate dehydratase activity; zinc ion binding Biological Process: secretion; bicarbonate transport; cellular response to stress; morphogenesis of an epithelium; one-carbon compound metabolic process Reference #:  Q16790 (UniProtKB) Alt. Names/Synonyms: CA-IX; CA9; CAH9; CAIX; Carbonate dehydratase IX; Carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; MN; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; Renal cell carcinoma-associated antigen G250 Gene Symbols: CA9 Molecular weight: 49,698 Da Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CA9 2HKF - P=83-91 (human) 3IAI - A/D/C/B=137-391 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2HKF 3IAI  |  ENZYME  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell motility, induced: T443‑p enzymatic activity, induced: T443‑p enzymatic activity, inhibited: S448‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		T115-g	LKLEDLPtVEAPGDP
1	0		T443-p	RRQHRRGtKGGVsyR
1	0		S448-p	RGtKGGVsyRPAEVA
2	4		Y449-p	GtKGGVsyRPAEVAE

	mouse
T98	LGLEDLSTPEAPEHS
T421	QHRHRSGTKDRVSYS
S426	SGTKDRVSYSPAEMT
Y427	GTKDRVSYSPAEMTE

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