Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Forms oligomers linked by disulfide bonds. By hypoxia. Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). Belongs to the alpha-carbonic anhydrase family. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Energy Metabolism - nitrogen; Lyase; Membrane protein, integral; Nucleolus
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: basolateral plasma membrane; microvillus membrane; integral to membrane; nucleolus; plasma membrane
Molecular Function: carbonate dehydratase activity; zinc ion binding
Biological Process: response to drug; secretion; bicarbonate transport; morphogenesis of an epithelium; one-carbon compound metabolic process; response to testosterone stimulus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.