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Protein Page:
CA9 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CA9 Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Forms oligomers linked by disulfide bonds. By hypoxia. Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). Belongs to the alpha-carbonic anhydrase family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Lyase; EC 4.2.1.1; Nucleolus; Energy Metabolism - nitrogen
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: basolateral plasma membrane; microvillus membrane; nucleolus; integral to membrane; plasma membrane
Molecular Function: carbonate dehydratase activity; zinc ion binding
Biological Process: response to drug; secretion; bicarbonate transport; morphogenesis of an epithelium; one-carbon compound metabolic process; response to testosterone stimulus
Reference #:  Q16790 (UniProtKB)
Alt. Names/Synonyms: CA-IX; CA9; CAH9; CAIX; Car9; Carbonate dehydratase IX; Carbonic anhydrase 9; Carbonic anhydrase IX; G250; Membrane antigen MN; MN; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; Renal cell carcinoma-associated antigen G250
Gene Symbols: CA9
Molecular weight: 49,698 Da
Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CA9

Protein Structure Not Found.


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Sites Implicated In
cell motility, induced: T443‑p
enzymatic activity, induced: T443‑p
enzymatic activity, inhibited: S448‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T115-gl LKLEDLPtVEAPGDP
0 1 T115-ga LKLEDLPtVEAPGDP
1 0 T443-p RRQHRRGtKGGVsyR
1 1 S448-p RGtKGGVsyRPAEVA
2 5 Y449-p GtKGGVsyRPAEVAE
  mouse

 
T98 LGLEDLSTPEAPEHS
T98 LGLEDLSTPEAPEHS
T421 QHRHRSGTKDRVSYS
S426 SGTKDRVSYSPAEMT
Y427 GTKDRVSYSPAEMTE
  rat

 
T98 LALEDLPTPEAPENR
T98 LALEDLPTPEAPENR
- under review  
T426 SGTKDGVTYSPAEMT
Y427 GTKDGVTYSPAEMTE
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