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Protein Page:
CSFR (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CSFR an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; Membrane protein, integral; TK group; PDGFR family
Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; intracellular; receptor complex
Molecular Function: macrophage colony stimulating factor receptor activity; protein homodimerization activity; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; protein kinase activity; transferase activity; protein binding; cytokine binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding
Biological Process: regulation of bone resorption; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; positive regulation of osteoclast differentiation; immune system process; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; osteoclast differentiation; protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; cell proliferation; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; phosphatidylinositol metabolic process; positive regulation of protein amino acid phosphorylation; intercellular junction maintenance; inflammatory response; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
Reference #:  P09581 (UniProtKB)
Alt. Names/Synonyms: AI323359; c-fms; CD115; colony stimulating factor 1 receptor; CSF-1-R; CSF-1R; Csf1r; Csfmr; Fim-2; Fms; M-CSFR; Macrophage colony-stimulating factor 1 receptor; OTTMUSP00000015851; Proto-oncogene c-Fms; proto-oncogene fms
Gene Symbols: Csf1r
Molecular weight: 109,179 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CSFR

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y807‑p
apoptosis, inhibited: Y559‑p, Y807‑p
cell cycle regulation: Y559‑p, Y697‑p, Y807‑p
cell differentiation, altered: Y544‑p, Y559‑p, Y697‑p, Y721‑p, Y807‑p, Y974‑p
cell growth, altered: Y544‑p, Y559‑p, Y697‑p, Y721‑p, Y807‑p, Y921‑p
cell motility, altered: Y559‑p, Y697‑p, Y721‑p
cytoskeletal reorganization: Y559‑p, Y697‑p, Y706‑p, Y721‑p, Y921‑p, Y974‑p
transcription, altered: Y559‑p, Y807‑p
transcription, induced: Y559‑p, Y807‑p
activity, induced: Y559‑p, Y697‑p, Y706‑p
enzymatic activity, induced: Y544‑p, Y559‑p, Y697‑p, Y706‑p, Y721‑p, Y807‑p
molecular association, regulation: Y559‑p, Y697‑p, Y721‑p, Y807‑p, Y921‑p, Y974‑p
phosphorylation: Y559‑p
protein degradation: Y559‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 2 T361-p QRAIYRYtFKLFLNR
4 0 Y544-p KYKQKPKyQVRWKII
0 1 R553 VRWKIIERYEGNSyT
0 7 Y554 RWKIIERYEGNSyTF
10 7 Y559-p ERYEGNSyTFIDPTQ
0 1 T560 RYEGNSyTFIDPTQL
0 1 T565 SyTFIDPTQLPYNEk
0 4 Y569 IDPTQLPYNEkWEFP
0 2 K572-u TQLPYNEkWEFPRNN
0 3 K584-u RNNLQFGkTLGAGAF
0 3 K604-u ATAFGLGkEDAVLKV
0 2 S686 AMLGPSLSPGQDSEG
0 2 S695-p GQDSEGDsSykNIHL
14 36 Y697-p DSEGDsSykNIHLEK
0 1 K698-u SEGDsSykNIHLEKK
12 0 Y706-p NIHLEKKyVRRDsGF
0 4 S711-p KKyVRRDsGFsSQGV
0 2 S714-p VRRDsGFsSQGVDTy
14 1 Y721-p sSQGVDTyVEMRPVS
0 1 K791-u LTSGHVAkIGDFGLA
21 14 Y807-p DIMNDSNyVVkGNAR
0 3 K810-u NDSNyVVkGNARLPV
0 2 K868-u NKFYKLVkDGYQMAQ
0 7 Y871 YKLVkDGYQMAQPVF
3 2 Y921-p LERRDQDyANLPSSG
2 0 Y974-p PLLQPNNyQFC____
3083 : Phospho-M-CSF Receptor (Tyr546) Antibody
3399 : Phospho-M-CSF Receptor (Tyr699) Antibody
3080 : Phospho-M-CSF Receptor (Tyr708) Antibody
3151 : Phospho-M-CSF Receptor (Tyr723) Antibody
3155 : Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb
3154 : Phospho-M-CSF Receptor (Tyr809) Antibody
3406 : Phospho-M-CSF Receptor (Tyr923) Antibody
  human

 
T363-p TKDTYRHtFTLSLPR
Y546-p KYKQKPKyQVRWKII
S555-p VRWKIIEsyEGNSyt
Y556-p RWKIIEsyEGNSytF
Y561-p EsyEGNSytFIDPtQ
T562-p syEGNSytFIDPtQL
T567-p SytFIDPtQLPyNEK
Y571-p IDPtQLPyNEKWEFP
K574 tQLPyNEKWEFPRNN
K586-u RNNLQFGkTLGAGAF
K606 ATAFGLGKEDAVLKV
S688-p AMLGPSLsPGQDPEG
V697 GQDPEGGVDyKNIHL
Y699-p DPEGGVDyKNIHLEK
K700 PEGGVDyKNIHLEKK
Y708-p NIHLEKKyVRRDsGF
S713-p KKyVRRDsGFsSQGV
S716-p VRRDsGFsSQGVDTy
Y723-p sSQGVDTyVEMRPVS
K793 LTNGHVAKIGDFGLA
Y809-p DIMNDSNyIVkGNAR
K812-u NDSNyIVkGNARLPV
K870-u SKFYKLVkDGyQMAQ
Y873-p YKLVkDGyQMAQPAF
Y923-p EDRRERDyTNLPSSS
Y969 PLLQPNNYQFC____
3083 : Phospho-M-CSF Receptor (Tyr546) Antibody
3399 : Phospho-M-CSF Receptor (Tyr699) Antibody
12251 : Phospho-M-CSF Receptor (Tyr699) (D10B11) Rabbit mAb
3080 : Phospho-M-CSF Receptor (Tyr708) Antibody
3151 : Phospho-M-CSF Receptor (Tyr723) Antibody
3155 : Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb
3154 : Phospho-M-CSF Receptor (Tyr809) Antibody
3406 : Phospho-M-CSF Receptor (Tyr923) Antibody
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