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CSFR (mouse)

Overview CSFR an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors. Note: This description may include information from UniProtKB. Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; EC 2.7.10.1; TK group; PDGFR family Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; receptor complex Molecular Function: transferase activity; macrophage colony stimulating factor receptor activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; cytokine binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity Biological Process: regulation of bone resorption; phosphoinositide-mediated signaling; peptidyl-tyrosine phosphorylation; positive regulation of osteoclast differentiation; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; osteoclast differentiation; protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat3 protein; cell proliferation; regulation of cell shape; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; positive regulation of protein amino acid phosphorylation; phosphatidylinositol metabolic process; intercellular junction maintenance; inflammatory response; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration Reference #:  P09581 (UniProtKB) Alt. Names/Synonyms: AI323359; c-fms; CD115; colony stimulating factor 1 receptor; CSF-1-R; CSF-1R; Csf1r; Csfmr; Fim-2; Fms; M-CSFR; Macrophage colony-stimulating factor 1 receptor; OTTMUSP00000015851; Proto-oncogene c-Fms; proto-oncogene fms Gene Symbols: Csf1r Molecular weight: 109,179 Da Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CSFR 3EJJ - X=20-296 (mouse) 4EXP - X=20-298 (mouse) 2I0V - A=538-922 (human) 2I0Y - A=538-922 (human) 2I1M - A=538-922 (human) 2OGV - A=543-918 (human) 3BEA - A=753-922 (human) 3DPK - A=183-334 (human) 3KRJ - A=753-922 (human) 3KRL - A=753-922 (human) 3LCD - A=741-919 (human) 3LCO - A=742-919 (human) 4DKD - C=20-299 (human) 4HW7 - A=542-919 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3EJJ 4EXP  |  ENZYME  |  Phospho3D  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: Y807‑p apoptosis, inhibited: Y559‑p, Y807‑p cell cycle regulation: Y559‑p, Y697‑p, Y807‑p cell differentiation, altered: Y544‑p, Y559‑p, Y697‑p, Y721‑p, Y807‑p, Y974‑p cell growth, altered: Y544‑p, Y559‑p, Y697‑p, Y721‑p, Y807‑p, Y921‑p cell motility, altered: Y559‑p, Y697‑p, Y721‑p cytoskeletal reorganization: Y559‑p, Y697‑p, Y706‑p, Y721‑p, Y921‑p, Y974‑p transcription, altered: Y559‑p, Y807‑p activation: Y559‑p, Y697‑p, Y706‑p enzymatic activity, induced: Y544‑p, Y559‑p, Y697‑p, Y706‑p, Y721‑p, Y807‑p molecular association, regulation: Y559‑p, Y697‑p, Y721‑p, Y807‑p, Y921‑p, Y974‑p phosphorylation: Y559‑p protein degradation: Y559‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		T179	SNTYVCKTMVNGRES
0	1		Y360-p	TQRAIYRytFKLFLN
0	2		T361-p	QRAIYRytFKLFLNR
0	1		K363	AIYRytFKLFLNRVK
0	1		Y495-p	SVGNSSQyFRAVSLG
4	0		Y544-p	KYKQKPKyQVRWKII
0	1		R553	VRWKIIERYEGNSyT
0	7		Y554	RWKIIERYEGNSyTF
0	1		S558	IERYEGNSyTFIDPT
10	7		Y559-p	ERYEGNSyTFIDPTQ
0	1		T560	RYEGNSyTFIDPTQL
0	1		T565	SyTFIDPTQLPYNEk
0	4		Y569	IDPTQLPYNEkWEFP
0	2		K572-u	TQLPYNEkWEFPRNN
0	3		K584-u	RNNLQFGkTLGAGAF
0	3		K604-u	ATAFGLGkEDAVLkV
0	1		K610-u	GkEDAVLkVAVKMLK
0	1		S684	AEAMLGPSLSPGQDs
0	2		S686	AMLGPSLSPGQDsEG
0	1		S691-p	SLSPGQDsEGDssyk
0	2		S695-p	GQDsEGDssykNIHL
0	1		S696-p	QDsEGDssykNIHLE
14	36		Y697-p	DsEGDssykNIHLEK
0	1		K698-u	sEGDssykNIHLEKK
12	0		Y706-p	NIHLEKKyVRRDsGF
0	3		S711-p	KKyVRRDsGFsSQGV
0	2		S714-p	VRRDsGFsSQGVDTy
13	1		Y721-p	sSQGVDTyVEMRPVS
0	1		K737-u	SSSDSFFkQDLDKEA
0	1		K791-u	LTSGHVAkIGDFGLA
21	14		Y807-p	DIMNDSNyVVkGNAR
0	3		K810-u	NDSNyVVkGNARLPV
0	2		K868-u	NKFYKLVkDGYQMAQ
0	7		Y871	YKLVkDGYQMAQPVF
3	2		Y921-p	LERRDQDyANLPSSG
2	0		Y974-p	PLLQPNNyQFC____

	human
S178-p	QSQDYQCsALMGGRK
H362	TTKDTYRHtFtLSLP
T363-p	TKDTYRHtFtLSLPR
T365-p	DTYRHtFtLSLPRLK
A497	SVGSGSWAFIPISAG
Y546-p	KYKQKPKyQVRWKII
S555-p	VRWKIIEsyEGNsyt
Y556-p	RWKIIEsyEGNsytF
S560-p	IEsyEGNsytFIDPt
Y561-p	EsyEGNsytFIDPtQ
T562-p	syEGNsytFIDPtQL
T567-p	sytFIDPtQLPyNEK
Y571-p	IDPtQLPyNEKWEFP
K574	tQLPyNEKWEFPRNN
K586-u	RNNLQFGkTLGAGAF
K606	ATAFGLGKEDAVLKV
K612	GKEDAVLKVAVKMLK
S686-p	AEAMLGPsLsPGQDP
S688-p	AMLGPsLsPGQDPEG
P693	sLsPGQDPEGGVDyK
V697	GQDPEGGVDyKNIHL
D698	QDPEGGVDyKNIHLE
Y699-p	DPEGGVDyKNIHLEK
K700	PEGGVDyKNIHLEKK
Y708-p	NIHLEKKyVRRDsGF
S713-p	KKyVRRDsGFsSQGV
S716-p	VRRDsGFsSQGVDTy
Y723-p	sSQGVDTyVEMRPVS
E739	SSNDSFSEQDLDKED
K793	LTNGHVAKIGDFGLA
Y809-p	DIMNDSNyIVkGNAR
K812-u	NDSNyIVkGNARLPV
K870-u	SKFYKLVkDGyQMAQ
Y873-p	YKLVkDGyQMAQPAF
Y923-p	EDRRERDyTNLPSSS
Y969	PLLQPNNYQFC____

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