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Protein Page:
FREQ (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FREQ Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel. Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes with CALN2/CABP7 binding to PI4KB. Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in a calcium-dependent manner with PICK1 (via AH domain). Interacts with IL1RAPL1. Belongs to the recoverin family. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding protein
Cellular Component: postsynaptic membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; axon; postsynaptic density; cytoplasm; dendrite; plasma membrane; cytoplasmic vesicle; cell junction; cytosol
Molecular Function: voltage-gated calcium channel activity; protein binding; magnesium ion binding; calcium ion binding; protein kinase binding
Biological Process: phosphoinositide-mediated signaling; positive regulation of exocytosis
Reference #:  P62166 (UniProtKB)
Alt. Names/Synonyms: DKFZp761L1223; FLUP; FREQ; Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein; NCS-1; NCS1; Neuronal calcium sensor 1
Gene Symbols: NCS1
Molecular weight: 21,879 Da
Basal Isoelectric point: 4.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FREQ

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K25-ub RKTYFTEkEVQQWYK
0 1 K50 LDAAGFQKIYkQFFP
0 2 K53-ub AGFQKIYkQFFPFGD
0 1 K106 EKLRWAFKLYDLDND
0 26 Y115-p YDLDNDGyITRNEML
0 1 T144-p ELPEEENtPEKRVDR
  mouse

 
K25 RKTYFTEKEVQQWYK
K50-ub LDAAGFQkIYkQFFP
K53-ub AGFQkIYkQFFPFGD
K106-ub EKLRWAFkLYDLDND
Y115 YDLDNDGYITRNEML
T144 ELPEEENTPEKRVDR
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