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Protein Page:
CYLD (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CYLD Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline-rich C-terminal region). Interacts with TRAF2 and TRIP. Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and DDX58. Interacts (via CAP-Gly domain) with microtubules. Interacts with HDAC6 and BCL3. Interacts with SQSTM1 and MAP3K7. Identified in a complex with TRAF6 and SQSTM1. Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. Inhibited by phosphorylation at serine residues. Belongs to the peptidase C67 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin-specific protease; EC 3.1.2.15; Protease; Ubiquitin conjugating system; EC 3.4.19.12
Cellular Component: microtubule; extrinsic to internal side of plasma membrane; cytoskeleton; membrane; cytoplasmic microtubule; cytoplasm; plasma membrane; midbody; cytosol
Molecular Function: peptidase activity; protein binding; zinc ion binding; hydrolase activity; metal ion binding; ubiquitin-specific protease activity; protein kinase binding; cysteine-type peptidase activity
Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; Wnt receptor signaling pathway; inhibition of NF-kappaB transcription factor; regulation of mitotic cell cycle; innate immune response; negative regulation of NF-kappaB import into nucleus; proteolysis
Reference #:  Q80TQ2 (UniProtKB)
Alt. Names/Synonyms: 2010013M14Rik; 2900009M21Rik; C130039D01Rik; CDMT; Cyld; Cyld1; cylindromatosis (turban tumor syndrome); Deubiquitinating enzyme CYLD; EAC; Kiaa0849; mKIAA0849; Probable ubiquitin carboxyl-terminal hydrolase CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD
Gene Symbols: Cyld
Molecular weight: 106,586 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CYLD

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell growth, induced: S414
enzymatic activity, inhibited: S414

Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 2 S13 WSQEKVTsPyWEERI
0 4 Y15 QEKVTsPyWEERIFY
0 2 S45 LLKVPKGSIGQYIQD
0 7 Y181 QGFTDGVYQGKQLFQ
0 2 S341 PKVTGSTSDPGSRNR
0 3 Y353 RNRSELFYTLNGSSV
0 2 S383 VAEDPAKSLTEMSSD
1 0 - under review  
0 1 S395 SSDFGHSSPPPQPPS
3 33 S414 SSENRFHsLPFsLtK
1 7 S418 RFHsLPFsLtKMPNT
0 2 T420 HsLPFsLtKMPNTNG
1 0 S428 KMPNTNGSMAHSPLS
1 0 S432 TNGSMAHSPLSLSVQ
1 0 S435 SMAHSPLSLSVQSVM
1 0 S437 AHSPLSLSVQSVMGE
1 0 S440 PLSLSVQSVMGELNS
0 1 S543 RPDSRFASLQPVSNQ
1 0 - under review  
  human

 
S13 WSQEKVTsPyWEERI
Y15 QEKVTsPyWEERIFY
S45 LLKVPKGsIGQYIQD
Y181 QGFTDGVYQGKQLFQ
S344 PKATGSTsDPGNRNR
Y356 RNRSELFyTLNGSsV
S387 VAEDPAKsLTEISTD
S362 FyTLNGSsVDSQPQS
S399 STDFDRSsPPLQPPP
S418 TTENRFHsLPFsLtK
S422 RFHsLPFsLtKMPNT
T424 HsLPFsLtKMPNTNG
S432 KMPNTNGsIGHsPLs
S436 TNGsIGHsPLsLsAQ
S439 sIGHsPLsLsAQsVM
S441 GHsPLsLsAQsVMEE
S444 PLsLsAQsVMEELNT
S547 RPDSRFAsLQPVSNQ
S772 LFKKIFPsLELNITD
4500 : Phospho-CYLD (Ser418) Antibody
  rat

 
S13 WNQEKVTSPyWEERL
Y15 QEKVTSPyWEERLFY
S45 LLRVPKGSIGQYIQD
Y181 QGFTDGVyQGKQLFQ
S341 PKVTGSTSDPGSRNR
Y353 RNRSELFYTLNGSSV
S384 VAEDPAKSLTEMSSD
- under review  
S396 SSDFGHSSPPPQPPS
S415 SSENRFHSLPFSLTK
S419 RFHSLPFSLTKMPNT
T421 HSLPFSLTKMPNTNG
S429 KMPNTNGSMAHSPLS
S433 TNGSMAHSPLSLSVQ
S436 SMAHSPLSLSVQSVM
S438 AHSPLSLSVQSVMGE
S441 PLSLSVQSVMGELNS
S544 RPDSRFASLQPVSNQ
- under review  
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