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IRF4 (human)

Overview IRF4 Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: cytoplasm; nucleolus; nucleus; cytosol Molecular Function: protein binding; sequence-specific DNA binding; transcription factor binding; transcription factor activity Biological Process: transcription, DNA-dependent; T cell activation; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-2 biosynthetic process; regulation of T-helper cell differentiation; myeloid dendritic cell differentiation; defense response to protozoan; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-4 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; negative regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding Reference #:  Q15306 (UniProtKB) Alt. Names/Synonyms: Interferon regulatory factor 4; IRF-4; IRF4; LSIRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM1; NF-EM5 Gene Symbols: IRF4 Molecular weight: 51,772 Da Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IRF4 2DLL - A=22-130 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K36-u	IDQIDSGkyPGLVWE
0	3		Y37-p	DQIDSGkyPGLVWEN
0	1		K59-u	IPWKHAGkQDYNREE
0	1		K103-a	RLRCALNkSNDFEEL
0	15		K103-u	RLRCALNkSNDFEEL
0	4		Y122-p	QLDISDPykVyRIVP
0	8		K123-u	LDISDPykVyRIVPE
0	3		Y125-p	ISDPykVyRIVPEGA
0	1		Y192-p	QPHPEIPyQCPMTFG
0	17		K264-u	YYREILVkELTTSSP
0	2		K306-u	GQRKNIEkLLSHLER
0	1		Y325-p	WMAPDGLyAkRLCQS
0	17		K327-u	APDGLyAkRLCQSRI
0	1		K349-u	LCNDRPNkLERDQTC
0	5		K357-u	LERDQTCkLFDTQQF
0	11		K399-u	PDPQRQRkLITAHVE
0	3		Y428-p	SGHFLRGyDLPEHIS
0	3		Y440-p	HISNPEDyHRSIRHS

	mouse
K36	IDQIDSGKYPGLVWE
Y37	DQIDSGKYPGLVWEN
K59	IPWKHAGKQDYNREE
K103	RLRCALNKSNDFEEL
K103	RLRCALNKSNDFEEL
Y122	QLDISDPYKVYRIVP
K123	LDISDPYKVYRIVPE
Y125	ISDPYKVYRIVPEGA
Y192	QSHPEIPYQCPVTFG
K264	YYRDILVKELTTTSP
K306	GQRKNIEKLLSHLER
Y325	WMAPDGLYAKRLCQS
K327	APDGLYAKRLCQSRI
K349	LCSDRPNKLERDQTC
K357	LERDQTCKLFDTQQF
K399	PDPQRQRKLITAHVE
Y428	TGHFLRGYELPEHVT
Y439	EHVTTPDYHRSLRHs

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