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Protein Page:
IRF4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRF4 Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleus; cytosol
Molecular Function: protein binding; sequence-specific DNA binding; protein-lysine N-methyltransferase activity; transcription factor binding; transcription factor activity
Biological Process: transcription, DNA-dependent; T cell activation; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; regulation of T-helper cell differentiation; myeloid dendritic cell differentiation; defense response to protozoan; peptidyl-lysine methylation; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-4 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; negative regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding
Reference #:  Q15306 (UniProtKB)
Alt. Names/Synonyms: Interferon regulatory factor 4; IRF-4; IRF4; LSIRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM1; NF-EM5
Gene Symbols: IRF4
Molecular weight: 51,772 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRF4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K36-ub IDQIDSGkyPGLVWE
0 4 Y37-p DQIDSGkyPGLVWEN
0 1 S48-p VWENEEKsIFRIPWK
0 1 K59-ub IPWKHAGkQDyNREE
1 0 Y62-p KHAGkQDyNREEDAA
0 1 K103-ac RLRCALNkSNDFEEL
0 15 K103-ub RLRCALNkSNDFEEL
1 4 Y122-p QLDISDPykVyRIVP
0 8 K123-ub LDISDPykVyRIVPE
1 3 Y125-p ISDPykVyRIVPEGA
1 0 S177-p MMPPLDRsWRDyVPD
1 0 Y181-p LDRsWRDyVPDQPHP
1 1 Y192-p QPHPEIPyQCPMTFG
0 17 K264-ub YYREILVkELTTSSP
0 2 K306-ub GQRKNIEkLLSHLER
1 1 Y325-p WMAPDGLyAkRLCQS
0 17 K327-ub APDGLyAkRLCQSRI
0 1 K349-ub LCNDRPNkLERDQTC
0 5 K357-ub LERDQTCkLFDTQQF
0 11 K399-ub PDPQRQRkLITAHVE
1 3 Y428-p SGHFLRGyDLPEHIS
0 3 Y440-p HISNPEDyHRSIRHs
1 0 S447-p yHRSIRHsSIQE___
  mouse

 
K36 IDQIDSGKYPGLVWE
Y37 DQIDSGKYPGLVWEN
S48 VWENEEKSVFRIPWK
K59 IPWKHAGKQDYNREE
Y62 KHAGKQDYNREEDAA
K103 RLRCALNKSNDFEEL
K103 RLRCALNKSNDFEEL
Y122 QLDISDPYKVYRIVP
K123 LDISDPYKVYRIVPE
Y125 ISDPYKVYRIVPEGA
S177 MMPPHDRSWRDYAPD
Y181 HDRSWRDYAPDQSHP
Y192 QSHPEIPYQCPVTFG
K264 YYRDILVKELTTTSP
K306 GQRKNIEKLLSHLER
Y325 WMAPDGLYAKRLCQS
K327 APDGLYAKRLCQSRI
K349 LCSDRPNKLERDQTC
K357 LERDQTCKLFDTQQF
K399 PDPQRQRKLITAHVE
Y428 TGHFLRGYELPEHVT
Y439 EHVTTPDYHRSLRHs
S446-p YHRSLRHsSIQE___
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