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Protein Page:
PHACTR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PHACTR1 Belongs to the phosphatase and actin regulator family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: synapse; cytosol; cell junction; nucleus
Molecular Function: protein phosphatase inhibitor activity; actin binding
Biological Process: actin cytoskeleton reorganization; actomyosin structure organization and biogenesis; negative regulation of catalytic activity; stress fiber formation; cell motility involved in cell locomotion
Reference #:  Q9C0D0 (UniProtKB)
Alt. Names/Synonyms: dJ257A7.2; KIAA1733; MGC126575; MGC126577; PHACTR1; PHAR1; Phosphatase and actin regulator 1; RPEL; RPEL repeat containing 1; RPEL1
Gene Symbols: PHACTR1
Molecular weight: 66,308 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Select Structure to View Below

PHACTR1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T39 GAQARRATLLLPPTL
0 1 T45 ATLLLPPTLMAASSE
0 4 S67-p IRRVRSKsDTPYLAE
0 1 S78 YLAEARISFNLGAAE
0 2 S97-p LAAMRSDsLVPGTHt
0 1 T102 SDsLVPGTHtPPIRR
0 7 T104-p sLVPGTHtPPIRRRS
0 1 K121 ANLGRIFKPWKWRKK
0 2 S145 AALERKISMRQsREE
0 1 S149-p RKISMRQsREELIKR
0 3 S237-p PCLPVKLsPPLPPKK
0 1 S329 MTMQRLESSEQRVPC
0 2 S339 QRVPCSTSYHSSGLH
0 4 K353 HSGDGVTKAGPMGLP
0 1 S423 MKVCRKDSLAIKLSN
0 27 S467-p TKLTRRLsQRPtAEE
0 1 T471-p RRLsQRPtAEELEQR
0 1 S505-p RRLTRKLsQRPTVEE
0 1 S523 RKILIRFSDyVEVAD
0 3 Y525-p ILIRFSDyVEVADAQ
0 3 K550 TRLTAADKAAIRKEL
0 1 S571-p EMEVHELsRHLTRFH
  mouse

► Hide Isoforms
 
T39-p GAQARRAtLLLPPtL
T45-p AtLLLPPtLMAASSE
S67-p IRRVRSKsDTPYLAE
S78-p YLAEARIsFNLGAAE
S97-p LAAMRSDsLVPGtHt
T102-p SDsLVPGtHtPPIRR
T104-p sLVPGtHtPPIRRRS
K121 ANLGRIFKPWKWRKK
S145-p AALERKIsMRQSREE
S149 RKIsMRQSREELIKR
S237-p PCLPVKLsPPLPPKK
S329-p MTMQRLEsSEQRVPC
S339 QRVPCSTSYHSSGLH
K353 HSSDGITKAGPMGLP
S423-p MKVCRKDsLAIKLSN
S467-p TKLTRRLsQRPTAEE
T471 RRLsQRPTAEELEQR
S505 RRLTRKLSQRPTVEE
S523 RKILIRFSDYVEVAD
Y525 ILIRFSDYVEVADAQ
K550 TRLTAADKAAIRKEL
S571 EMEVHELSRHLTRFH
  PHACTR1 iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S31 DFFRRRLSQRPTAEE
T35 RRLSQRPTAEELEQR
S69 RRLTRKLSQRPTVEE
S87 RKILIRFSDYVEVAD
Y89 ILIRFSDYVEVADAQ
K114 TRLTAADKAAIRKEL
S135 EMEVHELSRHLTRFH
  rat

 
T39 GAQARRATLLLPPTL
T45 ATLLLPPTLMAASSE
S67 IRRVRSKSDTPYLAE
S78 YLAEARISFNLGAAE
S97-p LAAMRSDsLVPGTHt
T102 SDsLVPGTHtPPIRR
T104-p sLVPGTHtPPIRRRS
K121-ub ANLGRIFkPWKWRKK
S145 AALERKISMRQSREE
S149 RKISMRQSREELIKR
S237 PCLPVKLSPPLPPKK
S329 MTMQRLESSEQRVPC
S339-p QRVPCSTsYHSSGLH
K353-ub HSSDGVTkAGPLGLP
S423 MKVCRKDSLAIKLSN
S467-p TKLTRRLsQRPTAEE
T471 RRLsQRPTAEELEQR
S505 RRLTRKLSQRPTVEE
S523-p RKILIRFsDyVEVAD
Y525-p ILIRFsDyVEVADAQ
K550-ub TRLTAADkAAIRKEL
S571 EMEVHELSRHLTRFH
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