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Protein Page:
ADAMTS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ADAMTS1 Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.4.24.-; Protease
Cellular Component: cytoplasm; basement membrane; cytoplasmic vesicle
Molecular Function: heparin binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity
Biological Process: integrin-mediated signaling pathway; negative regulation of cell proliferation; proteolysis; ovulation from ovarian follicle; kidney development
Reference #:  Q9UHI8 (UniProtKB)
Alt. Names/Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; ADAM metallopeptidase with thrombospondin type 1 motif, 1; ADAM-TS 1; ADAM-TS1; ADAMTS-1; ADAMTS1; ATS1; C3-C5; human metalloproteinase with thrombospondin type 1 motifs; KIAA1346; METH-1; METH1
Gene Symbols: ADAMTS1
Molecular weight: 105,358 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ADAMTS1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S16-p FGRRKLGsDMGNAER
0 1 T170-ga AASERLAtAAPGEKP
0 1 T197-ga RQGDVGGtCGVVDDE
0 1 T208-ga VDDEPRPtGKAETED
0 1 T574-p PWGDCSRtCGGGVQy
0 1 Y581-p tCGGGVQytMRECDN
0 1 T582-p CGGGVQytMRECDNP
0 1 K735-ub SGSVTSAkPGYHDII
0 1 Y838-p ALRPKIKyTyFVKKK
0 1 Y840-p RPKIKyTyFVKKKKE
  mouse

 
S16 SRKQKPCSDMGDVQR
P178 VATERLAPAVPEEES
K205 RRGSGGAKCGVMDDE
T216 MDDETLPTSDSRPES
T575 PWGDCSRTCGGGVQY
Y582 TCGGGVQYTMRECDN
T583 CGGGVQYTMRECDNP
R736 SGIVTSTRPGYHDIV
F839 ALRPKIKFTYFMKKK
Y841 RPKIKFTYFMKKKTE
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