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BSG (human)

Overview BSG Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Immunoglobulin superfamily; Transporter; Membrane protein, integral Cellular Component: Golgi membrane; mitochondrion; plasma membrane; melanosome; integral to membrane; sarcolemma; lipid raft; acrosomal membrane Molecular Function: mannose binding; protein binding Biological Process: response to mercury ion; response to peptide hormone stimulus; response to cAMP; cell surface receptor linked signal transduction; decidualization; pyruvate metabolic process; blood coagulation; leukocyte migration; embryo implantation; odontogenesis of dentine-containing teeth Reference #:  P35613 (UniProtKB) Alt. Names/Synonyms: 5F7; BASI; Basigin; basigin (Ok blood group); BSG; CD147; CD147 antigen; Collagenase stimulatory factor; EMMPRIN; Extracellular matrix metalloproteinase inducer; Leukocyte activation antigen M6; M6; OK; OK blood group antigen; TCSF; Tumor cell-derived collagenase stimulatory factor Gene Symbols: BSG Molecular weight: 42,200 Da Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BSG 3QQN - A/B=23-138 (human) 3QR2 - A/B=23-138 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3QQN 3QR2  |  DISEASE 109480 111380  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	14		K173-u	VTGHRWLkGGVVLkE
0	13		K179-u	LkGGVVLkEDALPGQ
0	1		K187-u	EDALPGQkTEFkVDS
0	1		K191-u	PGQkTEFkVDSDDQW
0	2		K227-u	PPRVKAVkSSEHINE
0	2		K257-u	VTDWAWYkITDSEDk
0	1		K264-u	kITDSEDkALMNGSE
0	1		T315-p	GSDQAIItLRVRSHL
0	4		K350-u	FIYEKRRkPEDVLDD
0	5		V354	KRRkPEDVLDDDDAG
0	8		S362-p	LDDDDAGsAPLkssG
0	9		K366-u	DAGsAPLkssGQHQN
0	1		S367-p	AGsAPLkssGQHQND
0	3		S368-p	GsAPLkssGQHQNDk
0	5		K375-u	sGQHQNDkGKNVRQR

	mouse
R173	IVGHRWMRGGKVLQE
Q179	MRGGKVLQEDTLPDL
H187	EDTLPDLHTKYIVDA
I191	PDLHTKYIVDADDRS
K227	PPRIKVGKKSEHSSE
K258	ITDWFWFKTSDTGEE
E266	TSDTGEEEAITNSTE
S319	GTTRETISLRVRSRM
K354-u	FIYEKRRkPDQtLDE
T358-p	KRRkPDQtLDEDDPG
A366	LDEDDPGAAPLKGsG
K370	DPGAAPLKGsGTHMN
G371	PGAAPLKGsGTHMND
S372-p	GAAPLKGsGTHMNDK
K379	sGTHMNDKDKNVRQR

	rat
R173	IVGHRWMRGGKVLQE
Q179	MRGGKVLQEDTLPDL
Q187	EDTLPDLQMKYTVDA
T191	PDLQMKYTVDADDRS
K227	PPRIKVGKKSEHASE
K258	VDEWVWFKTSDTGDQ
Q265	KTSDTGDQTISNGTE
S318	GSARETISLRVRSRL
K353	FIYEKRRKPDQtLDE
T357-p	KRRKPDQtLDEDDPG
A365	LDEDDPGAAPLKGSG
K369	DPGAAPLKGSGSHLN
G370	PGAAPLKGSGSHLND
S371	GAAPLKGSGSHLNDK
K378	SGSHLNDKDKNVRQR

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