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Protein Page:
BSG (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BSG Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Immunoglobulin superfamily
Cellular Component: Golgi membrane; mitochondrion; integral to plasma membrane; plasma membrane; melanosome; sarcolemma; acrosomal membrane; lipid raft
Molecular Function: mannose binding; protein binding
Biological Process: response to peptide hormone stimulus; extracellular matrix organization and biogenesis; response to cAMP; decidualization; odontogenesis of dentine-containing teeth; response to mercury ion; extracellular matrix disassembly; cellular metabolic process; cell surface receptor linked signal transduction; pyruvate metabolic process; blood coagulation; leukocyte migration; embryo implantation
Reference #:  P35613 (UniProtKB)
Alt. Names/Synonyms: 5F7; BASI; Basigin; basigin (Ok blood group); BSG; CD147; CD147 antigen; Collagenase stimulatory factor; EMMPRIN; Extracellular matrix metalloproteinase inducer; Leukocyte activation antigen M6; M6; OK; OK blood group antigen; TCSF; Tumor cell-derived collagenase stimulatory factor
Gene Symbols: BSG
Molecular weight: 42,200 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BSG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T145-ga EPGTVFTtVEDLGSK
0 14 K173-u VTGHRWLkGGVVLkE
0 13 K179-u LkGGVVLkEDALPGQ
0 1 K187-u EDALPGQkTEFKVDS
0 1 W198 KVDSDDQWGEYSCVF
0 2 K227-u PPRVKAVkSSEHINE
0 2 K257-u VTDWAWYkITDSEDk
0 1 K264-u kITDSEDkALMNGSE
0 4 K350-u FIYEKRRkPEDVLDD
0 5 V354 KRRkPEDVLDDDDAG
0 11 S362-p LDDDDAGsAPLkssG
0 9 K366-u DAGsAPLkssGQHQN
0 1 S367-p AGsAPLkssGQHQND
0 4 S368-p GsAPLkssGQHQNDk
0 5 K375-u sGQHQNDkGKNVRQR
  mouse

 
S145 EPGTIQTSVQEVNSK
R173 IVGHRWMRGGKVLQE
Q179 MRGGKVLQEDTLPDL
H187 EDTLPDLHTKYIVDA
S198-p IVDADDRsGEYSCIF
K227 PPRIKVGKKSEHSSE
K258 ITDWFWFKTSDTGEE
E266 TSDTGEEEAITNSTE
K354-u FIYEKRRkPDQtLDE
T358-p KRRkPDQtLDEDDPG
A366 LDEDDPGAAPLKGsG
K370 DPGAAPLKGsGTHMN
G371 PGAAPLKGsGTHMND
S372-p GAAPLKGsGTHMNDK
K379 sGTHMNDKDKNVRQR
  rat

 
S145 EPGTIVTSVQEVDSK
R173 IVGHRWMRGGKVLQE
Q179 MRGGKVLQEDTLPDL
Q187 EDTLPDLQMKYTVDA
S198 TVDADDRSGEYSCIF
K227 PPRIKVGKKSEHASE
K258 VDEWVWFKTSDTGDQ
Q265 KTSDTGDQTISNGTE
K353 FIYEKRRKPDQtLDE
T357-p KRRKPDQtLDEDDPG
A365 LDEDDPGAAPLKGSG
K369 DPGAAPLKGSGSHLN
G370 PGAAPLKGSGSHLND
S371 GAAPLKGSGSHLNDK
K378 SGSHLNDKDKNVRQR
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