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Protein Page:
SGCE (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SGCE Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCE are a cause of dystonia type 11 (DYT11); also known as myoclonic dystonia or alcohol- responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the sarcoglycan alpha/epsilon family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Cellular Component: dystrophin-associated glycoprotein complex; Golgi apparatus; cytoskeleton; integral to plasma membrane; plasma membrane; sarcoglycan complex; sarcolemma
Molecular Function: calcium ion binding
Biological Process: muscle development; cell-matrix adhesion
Reference #:  O43556 (UniProtKB)
Alt. Names/Synonyms: dystonia 11, myoclonic; DYT11; Epsilon-sarcoglycan; Epsilon-SG; ESG; sarcoglycan, epsilon; SGCE
Gene Symbols: SGCE
Molecular weight: 49,851 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Select Structure to View Below

SGCE

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K280-u ISLVDKTkQVSTYQE
0 1 K302-u LPDGGEYkPPSDSLK
  mouse

 
K280 ISLVDKTKQVSTYQE
K302 LPDGGEYKPPSDSLK
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