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Protein Page:
DDIT4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DDIT4 Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism. Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients. Belongs to the DDIT4 family. Note: This description may include information from UniProtKB.
Cellular Component: mitochondrion; cytoplasm; intracellular; cytosol
Biological Process: neuron differentiation; cell proliferation; negative regulation of TOR signaling pathway; protein complex disassembly; nerve growth factor receptor signaling pathway; negative regulation of peptidyl-serine phosphorylation; response to hypoxia; neuron migration; brain development; negative regulation of glycolysis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; defense response to virus
Reference #:  Q9NX09 (UniProtKB)
Alt. Names/Synonyms: DDIT4; Dig2; DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4; FLJ20500; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801 (RTP801); Protein regulated in development and DNA damage response 1; REDD-1; REDD1; RP11-442H21.1; RTP801
Gene Symbols: DDIT4
Molecular weight: 25,371 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  mTOR Signaling  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DDIT4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S18-p SSTSSSPsSLPRtPt
0 1 T23-p SPsSLPRtPtPDRPP
0 2 T25-p sSLPRtPtPDRPPRS
0 65 K129-ub QLVSQVGkELLRLAY
0 1 K155 DVCVEQGKSCHSVGQ
0 1 K188-ub LDSRLWPkIQGLFSS
0 1 K219-ub TGFRVIKkkLYSSEQ
0 3 K220-ub GFRVIKkkLYSSEQL
  mouse

 
S18 SSSSSSSSRTPAADR
T20 SSSSSSRTPAADRPP
A22 SSSSRTPAADRPPRS
K126-ub QLVSQVGkELLRLAY
K152-ub DVCVEQGkSCHSVAQ
K185 LDSRLWPKIQGLLSS
K216 TGFRVIKKkLYSSEQ
K217-ub GFRVIKKkLYSSEQL
  rat

 
S18 SSSSSSSSRTPAADR
T20 SSSSSSRTPAADRPP
A22 SSSSRTPAADRPPRS
K126 QLLSQVGKELLRLAY
K152 DVCVEQGKSCHSVAQ
K185 LDSRLWPKIQGLLSS
K216 TGFRVIKKKLYSSEQ
K217 GFRVIKKKLYSSEQL
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