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DDIT4 (human)

Overview DDIT4 Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism. Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients. Belongs to the DDIT4 family. Note: This description may include information from UniProtKB. Cellular Component: mitochondrion; cytoplasm; intracellular; cytosol Biological Process: neuron differentiation; cell proliferation; protein complex disassembly; negative regulation of TOR signaling pathway; nerve growth factor receptor signaling pathway; response to hypoxia; negative regulation of peptidyl-serine phosphorylation; neuron migration; brain development; negative regulation of glycolysis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; defense response to virus Reference #:  Q9NX09 (UniProtKB) Alt. Names/Synonyms: DDIT4; Dig2; DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4; FLJ20500; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801 (RTP801); Protein regulated in development and DNA damage response 1; REDD-1; REDD1; RP11-442H21.1; RTP801 Gene Symbols: DDIT4 Molecular weight: 25,371 Da Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states CST Pathways:  mTOR Signaling  |  Parkinson's Disease Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DDIT4 3LQ9 - A/B=89-226 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S18-p	SSTSSSPsSLPRTPT
0	65		K129-u	QLVSQVGkELLRLAY
0	1		K155	DVCVEQGKSCHSVGQ
0	1		K188-u	LDSRLWPkIQGLFSS
0	1		K219-u	TGFRVIKkkLYSSEQ
0	3		K220-u	GFRVIKkkLYSSEQL

	mouse
S18	SSSSSSSSRTPAADR
K126-u	QLVSQVGkELLRLAY
K152-u	DVCVEQGkSCHSVAQ
K185	LDSRLWPKIQGLLSS
K216	TGFRVIKKkLYSSEQ
K217-u	GFRVIKKkLYSSEQL

	rat
S18	SSSSSSSSRTPAADR
K126	QLLSQVGKELLRLAY
K152	DVCVEQGKSCHSVAQ
K185	LDSRLWPKIQGLLSS
K216	TGFRVIKKKLYSSEQ
K217	GFRVIKKKLYSSEQL

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