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Protein Page:
JAG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JAG1 Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: membrane; integral to plasma membrane; apical part of cell; plasma membrane; extracellular region
Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding; structural molecule activity
Biological Process: nervous system development; endothelial cell differentiation; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; keratinocyte differentiation; myoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of Notch signaling pathway
Reference #:  P78504 (UniProtKB)
Alt. Names/Synonyms: AGS; AHD; AWS; CD339; hJ1; JAG1; jagged 1 (Alagille syndrome); Jagged1; JAGL1; MGC104644; Protein jagged-1
Gene Symbols: JAG1
Molecular weight: 133,799 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JAG1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T219-p CDQNGNKtCMEGWMG
0 2 K1123-ub REQLNQIkNPIEKHG
0 57 Y1139-p NTVPIKDyENKNSkM
0 1 K1145-ac DyENKNSkMSkIRTH
0 1 K1148-ac NKNSkMSkIRTHNsE
0 1 S1154-p SkIRTHNsEVEEDDM
0 22 Y1176-p RFAKQPAytLVDREE
0 2 T1177-p FAKQPAytLVDREEK
0 1 T1189-p EEKPPNGtPTKHPNW
0 3 S1210-p RDLESAQsLNRMEYI
  mouse

 
T219 CDQNGNKTCMEGWMG
K1123 REQLNQIKNPIEKHG
Y1139-p NTVPIKDyENKNSKM
K1145 DyENKNSKMSKIRTH
K1148 NKNSKMSKIRTHNSE
S1154 SKIRTHNSEVEEDDM
Y1176 RFAKQPVYTLVDREE
T1177 FAKQPVYTLVDREEK
T1189 EEKAPSGTPTKHPNW
S1210-p RDLESAQsLNRMEYI
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