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JAG1 (human)

Overview JAG1 Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: membrane; apical part of cell; integral to plasma membrane; extracellular region; plasma membrane Molecular Function: growth factor activity; calcium ion binding; Notch binding; structural molecule activity Biological Process: endothelial cell differentiation; nervous system development; Notch signaling pathway; positive regulation of myeloid cell differentiation; multicellular organismal development; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; myoblast differentiation; keratinocyte differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of Notch signaling pathway Reference #:  P78504 (UniProtKB) Alt. Names/Synonyms: AGS; AHD; AWS; CD339; hJ1; JAG1; jagged 1 (Alagille syndrome); Jagged1; JAGL1; MGC104644; Protein jagged-1 Gene Symbols: JAG1 Molecular weight: 133,799 Da Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states CST Pathways:  Notch Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below JAG1 2KB9 - A=252-295 (human) 2VJ2 - A/B=185-335 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2KB9 2VJ2  |  Phospho3D  |  DISEASE 118450 187500 601920  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T219-p	CDQNGNKtCMEGWMG
0	2		K1123-u	REQLNQIkNPIEKHG
0	36		Y1139-p	NTVPIKDyENKNSkM
0	1		K1145-a	DyENKNSkMSkIRTH
0	1		K1148-a	NKNSkMSkIRTHNSE
0	13		Y1176-p	RFAKQPAytLVDREE
0	2		T1177-p	FAKQPAytLVDREEK
0	1		S1210	RDLESAQSLNRMEYI

	mouse
T219	CDQNGNKTCMEGWMG
K1123	REQLNQIKNPIEKHG
Y1139-p	NTVPIKDyENKNSKM
K1145	DyENKNSKMSKIRTH
K1148	NKNSKMSKIRTHNSE
Y1176	RFAKQPVYTLVDREE
T1177	FAKQPVYTLVDREEK
S1210-p	RDLESAQsLNRMEYI

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