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Protein Page:
Rab35 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rab35 In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. Interacts with DENND1A and DENND1B in a nucleotide- dependent manner. The low binding to DENND1C is nucleotide- independent. All 3 DENND1 act as GEFs for RAB35 and thus activate the protein. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric, Rab; G protein; G protein, monomeric
Cellular Component: intercellular bridge; mitochondrion; cell projection membrane; melanosome; plasma membrane; coated pit; endosome membrane; clathrin-coated endocytic vesicle
Molecular Function: GTPase activity; protein binding; phosphatidylinositol-4,5-bisphosphate binding; GDP binding; GTP binding
Biological Process: antigen processing and presentation; protein localization; protein transport; GTP catabolic process; small GTPase mediated signal transduction; cytokinesis; endosome transport; neurite development
Reference #:  Q15286 (UniProtKB)
Alt. Names/Synonyms: GTP-binding protein RAY; H-ray; RAB1C; RAB35; RAB35, member RAS oncogene family; Ras-related protein Rab-1C; ras-related protein rab-1c (GTP-binding protein ray); Ras-related protein Rab-35; RAY
Gene Symbols: RAB35
Molecular weight: 23,025 Da
Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rab35

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 Y5-p ___MARDyDHLFKLL
0 1 S17-p KLLIIGDsGVGKSSL
0 2 S36-p ADNTFSGsyItTIGV
0 11 Y37-p DNTFSGsyItTIGVD
0 1 T39-p TFSGsyItTIGVDFK
0 5 T72-p AGQERFRtItsTyYR
0 1 T74-p QERFRtItsTyYRGT
0 1 S75-p ERFRtItsTyYRGTH
0 1 Y77-p FRtItsTyYRGTHGV
0 1 K121-ub CRILVGNkNDDPERk
0 1 K128-ub kNDDPERkVVETEDA
0 1 Y136 VVETEDAYkFAGQMG
0 1 K137-ub VETEDAYkFAGQMGI
0 14 K178-ub AKKDNLAkQQQQQQN
0 7 K189-ub QQQNDVVkLTKNSKR
  mouse

 
Y5 ___MARDYDHLFKLL
S17 KLLIIGDSGVGKSSL
S36 ADNTFSGSYITTIGV
Y37 DNTFSGSYITTIGVD
T39 TFSGSYITTIGVDFK
T72-p AGQERFRtItSTYYR
T74-p QERFRtItSTYYRGT
S75 ERFRtItSTYYRGTH
Y77 FRtItSTYYRGTHGV
K121 CRILVGNKNDDPERK
K128 KNDDPERKVVETEDA
Y136-p VVETEDAyKFAGQMG
K137 VETEDAyKFAGQMGI
K178-ub AKKDNLAkQQQQQQN
K189-ub QQQNDVVkLTKNSKR
  rat

 
Y5 ___MARDYDHLFKLL
S17 KLLIIGDSGVGKSSL
S36 ADNTFSGSYITTIGV
Y37 DNTFSGSYITTIGVD
T39 TFSGSYITTIGVDFK
T72 AGQERFRTITSTYYR
T74 QERFRTITSTYYRGT
S75 ERFRTITSTYYRGTH
Y77 FRTITSTYYRGTHGV
K121 CRILVGNKNDDPERK
K128 KNDDPERKVVETEDA
Y136 VVETEDAYKFAGQMG
K137 VETEDAYKFAGQMGI
K178 AKKDNLAKQQQQQQN
K189 QQQNDVVKLTKNSKR
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