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Protein Page:
PLCG1 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PLCG1 a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.11; Phospholipase; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate
Cellular Component: signalosome; ruffle; neuron projection; cell projection; lamellipodium; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; glutamate receptor binding; signal transducer activity; phosphoric diester hydrolase activity; hydrolase activity; metal ion binding; neurotrophin TRKA receptor binding; phosphoprotein binding; calcium ion binding; receptor tyrosine kinase binding; phosphoinositide phospholipase C activity; insulin receptor binding
Biological Process: positive regulation of angiogenesis; inositol trisphosphate biosynthetic process; phospholipid catabolic process; in utero embryonic development; calcium ion transport; positive regulation of blood vessel endothelial cell migration; protein secretion; lipid metabolic process; signal transduction; T cell receptor signaling pathway; lipid catabolic process
Reference #:  Q62077 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; AI894140; Cded; cell differentiation and embryonic development; OTTMUSP00000001135; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1; Phospholipase C-gamma-1; Plc-1; PLC-gamma-1; Plc-gamma1; Plcg-1; Plcg1
Gene Symbols: Plcg1
Molecular weight: 149,668 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLCG1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell adhesion, altered: Y783‑p
cell cycle regulation: Y771‑p
cell motility, altered: Y771‑p
molecular association, regulation: Y783‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 2 K178-u RISAKDLkNMLSQVN
0 4 Y186-p NMLSQVNyRVPNMRF
0 10 Y210-p QRSGDITyGQFAQLy
0 2 Y217-p yGQFAQLyRSLMYSA
0 2 K226-u SLMYSAQkTMDLPFL
0 10 Y379-p PDGMPVIyHGHtLtt
0 1 T383-p PVIyHGHtLttKIKF
0 1 T385-p IyHGHtLttKIKFSD
0 1 T386-p yHGHtLttKIKFSDV
0 1 K389 HtLttKIKFSDVLHT
0 7 H428 QQRNMAQHFRkVLGD
0 3 K431-u NMAQHFRkVLGDTLL
0 3 K440-u LGDTLLTkPVDIAAD
0 9 S470 HKKLAEGSAyEEVPT
2 133 Y472-p KLAEGSAyEEVPTSV
0 82 Y481-p EVPTSVMySENDISN
0 3 Y496-p SIKNGILyLEDPVNH
0 31 Y506-p DPVNHEWyPHyFVLT
3 8 Y509-p NHEWyPHyFVLTSSK
0 4 Y518 VLTSSKIYYSEETSs
0 1 S525-p YYSEETSsDQGNEDE
0 1 T542 PKEASSSTELHSSEK
0 10 Y702 KRNEPNSYAISFRAE
0 2 T766 EALEKIGTAEPDyGA
0 1 D770 KIGTAEPDyGALyEG
11 567 Y771-p IGTAEPDyGALyEGR
2 392 Y775-p EPDyGALyEGRNPGF
61 558 Y783-p EGRNPGFyVEANPMP
0 7 Y833 GGWWRGDYGGKKQLW
0 2 K941-u DARLTEGkMMERRKK
0 35 Y959 ELSELVVYCRPVPFD
0 675 Y977-p IGTERACyRDMSSFP
0 3 S981 RACyRDMSSFPETKA
0 7 Y991 PETKAEKYVNKAKGK
0 24 Y1003 KGKKFLQYNRLQLSR
0 1 K1215-u KIDIFPAkENGDLsP
0 65 S1221-p AkENGDLsPFsGIsL
0 5 S1224-p NGDLsPFsGIsLRER
0 5 I1226 DLsPFsGIsLRERAS
0 30 S1227-p LsPFsGIsLRERASD
0 32 S1233 IsLRERASDAsSQLF
0 6 S1236-p RERASDAsSQLFHVR
3 241 S1248-p HVRAREGsFEARyQQ
0 14 A1251 AREGsFEARyQQPFE
10 62 Y1253-p EGsFEARyQQPFEDF
0 55 S1263-p PFEDFRIsQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  human

► Hide Isoforms
 
K178-u RISAKDLkNMLSQVN
Y186-p NMLSQVNyRVPNMRF
Y210-p QRSGDITyGQFAQLY
Y217 yGQFAQLYRSLMYSA
K226-u SLMYSAQkTMDLPFL
Y379-p PDGMPVIyHGHTLTT
T383 PVIyHGHTLTTKIkF
T385 IyHGHTLTTKIkFSD
T386 yHGHTLTTKIkFSDV
K389-u HTLTTKIkFSDVLHT
Y428-p QQRNMAQyFKkVLGD
K431-u NMAQyFKkVLGDTLL
K440-u LGDTLLTkPVEISAD
S470-p HKKLAEGsAyEEVPT
Y472-p KLAEGsAyEEVPTSM
Y481-p EVPTSMMySENDISN
Y496-p SIKNGILyLEDPVNH
Y506-p DPVNHEWyPHyFVLT
Y509-p NHEWyPHyFVLTSSK
Y518-p VLTSSKIyYSEETSs
S525-p yYSEETSsDQGNEDE
T542-p PKEVSSStELHSNEK
Y702-p KRNEPNSyAISFRAE
T766-p EALEKIGtAEPdyGA
D770-ca KIGtAEPdyGALyEG
Y771-p IGtAEPdyGALyEGR
Y775-p EPdyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
Y833-p GGWWRGDyGGKKQLW
K941-u DARLTEGkIMERRKK
Y959-p ELSELVVyCRPVPFD
Y977-p IGTERACyRDMsSFP
S981-p RACyRDMsSFPETKA
Y991-p PETKAEKyVNKAKGK
Y1003-p KGKKFLQyNRLQLSR
K1215 KIDIFPAKENGDLsP
S1221-p AKENGDLsPFsGtsL
S1224-p NGDLsPFsGtsLRER
T1226-p DLsPFsGtsLRERGs
S1227-p LsPFsGtsLRERGsD
S1233-p tsLRERGsDAsGQLF
S1236-p RERGsDAsGQLFHGR
S1248-p HGRAREGsFEsRyQQ
S1251-p AREGsFEsRyQQPFE
Y1253-p EGsFEsRyQQPFEDF
S1263-p PFEDFRIsQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  PLCG1 iso2  
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRSGDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
K226 SLMYSAQKTMDLPFL
Y379 PDGMPVIYHGHTLTT
T383 PVIYHGHTLTTKIKF
T385 IYHGHTLTTKIKFSD
T386 YHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
Y428 QQRNMAQYFKKVLGD
K431 NMAQYFKKVLGDTLL
K440 LGDTLLTKPVEISAD
S470 HKKLAEGSAYEEVPT
Y472 KLAEGSAYEEVPTSM
Y481 EVPTSMMYSENDISN
Y496 SIKNGILYLEDPVNH
Y506 DPVNHEWYPHYFVLT
Y509 NHEWYPHYFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
T542 PKEVSSSTELHSNEK
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDYGA
D770 KIGTAEPDYGALYEG
Y771 IGTAEPDYGALYEGR
Y775 EPDYGALYEGRNPGF
Y783 EGRNPGFYVEANPMP
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKIMERRKK
Y959 ELSELVVYCRPVPFD
Y977 IGTERACYRDMSSFP
S981 RACYRDMSSFPETKA
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDIFPAKQENGDLs
S1222-p KQENGDLsPFsGtsL
S1225-p NGDLsPFsGtsLRER
T1227-p DLsPFsGtsLRERGs
S1228-p LsPFsGtsLRERGsD
S1234-p tsLRERGsDAsGQLF
S1237-p RERGsDAsGQLFHGR
S1249 HGRAREGSFESRYQQ
S1252 AREGSFESRYQQPFE
Y1254 EGSFESRYQQPFEDF
S1264 PFEDFRISQEHLADH
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
  rat

 
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRSGDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
K226 SLMYSAQKTMDLPFL
Y379-p PDGMPVIyHGHTLTT
T383 PVIyHGHTLTTKIKF
T385 IyHGHTLTTKIKFSD
T386 yHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
H428 QQRNMAQHFRKVLGD
K431 NMAQHFRKVLGDTLL
K440 LGDTLLTKPVDIAAD
S470 HKKLAEGSAYEEVPT
Y472 KLAEGSAYEEVPTSV
Y481-p EVPTSVMySENDISN
Y496 SIKNGILYLEDPVNH
Y506-p DPVNHEWyPHyFVLT
Y509-p NHEWyPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
T542 PKEASGSTELHSSEK
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771-p IGTAEPDyGALyEGR
Y775-p EPDyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKMMERRKK
Y959 ELSELVVYCRPVPFD
Y977-p IGTERACyRDMSSFP
S981 RACyRDMSSFPETKA
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDIFPAKENGDLSP
S1221 AKENGDLSPFSGTSL
S1224 NGDLSPFSGTSLRER
T1226 DLSPFSGTSLRERAS
S1227 LSPFSGTSLRERASD
S1233 TSLRERASDASSQLF
S1236 RERASDASSQLFHVR
S1248 HVRAREGSFEARyQQ
A1251 AREGSFEARyQQPFE
Y1253-p EGSFEARyQQPFEDF
S1263 PFEDFRISQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  cow

 
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRTSDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
K226 SLMYSAQKTMDLPFL
Y379 PDGMPVIYHGHTLTT
T383 PVIYHGHTLTTKIKF
T385 IYHGHTLTTKIKFSD
T386 YHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
Y428 QQRNMAQYFKKVLGD
K431 NMAQYFKKVLGDTLL
K440 LGDTLLTKPVDIAAD
S470 HKKLAEGSAyEEVPT
Y472-p KLAEGSAyEEVPTSV
Y481 EVPTSVMYSENDISN
Y496 SIKNGILYLEDPVNH
Y506 DPVNHEWYPHyFVLT
Y509-p NHEWYPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
T542 PKEASGSTELHSNEK
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771-p IGTAEPDyGALyEGR
Y775-p EPDyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKMMERRKK
Y959 ELSELVVYCRPVPFD
Y977 IGTERACYRDMSSFP
S981 RACYRDMSSFPETKA
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDVFPAKQENGDLS
S1222 KQENGDLSPFGGASL
G1225 NGDLSPFGGASLRER
A1227 DLSPFGGASLRERSC
S1228 LSPFGGASLRERSCD
C1234 ASLRERSCDASGPLF
S1237 RERSCDASGPLFHGR
S1249 HGRAREGSFEARyQQ
A1252 AREGSFEARyQQPFE
Y1254-p EGSFEARyQQPFEDF
S1264 PFEDFRISQEHLADH
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