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Protein Page:
PLCG1 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PLCG1 a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate
Cellular Component: signalosome; ruffle; neuron projection; cell projection; lamellipodium; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; signal transducer activity; glutamate receptor binding; phosphoric diester hydrolase activity; hydrolase activity; neurotrophin TRKA receptor binding; phospholipid binding; phosphoprotein binding; calcium ion binding; receptor tyrosine kinase binding; phosphoinositide phospholipase C activity; insulin receptor binding
Biological Process: positive regulation of angiogenesis; phospholipid catabolic process; in utero embryonic development; inositol trisphosphate biosynthetic process; calcium ion transport; positive regulation of blood vessel endothelial cell migration; protein secretion; lipid metabolic process; signal transduction; T cell receptor signaling pathway; lipid catabolic process
Reference #:  Q62077 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; AI894140; Cded; cell differentiation and embryonic development; OTTMUSP00000001135; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1; Phospholipase C-gamma-1; Plc-1; PLC-gamma-1; Plc-gamma1; Plcg-1; Plcg1
Gene Symbols: Plcg1
Molecular weight: 149,668 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ErbB/HER Signaling  |  MAPK/Erk in Growth and Differentiation  |  Phospholipase Signaling  |  Regulation of Actin Dynamics  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLCG1
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell adhesion, altered: Y783‑p
cell cycle regulation: Y771‑p
cell motility, altered: Y771‑p
molecular association, regulation: Y783‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        mouse

 
0 1 Y93 TSRDFDRYQEDPAFR
0 2 K178-u RISAKDLkNMLSQVN
0 3 Y186-p NMLSQVNyRVPNMRF
0 10 Y210-p QRSGDITyGQFAQLy
0 2 Y217-p yGQFAQLyRSLMYSA
0 1 S219 QFAQLyRSLMYSAQk
0 2 K226-u SLMYSAQkTMDLPFL
0 1 A237 LPFLETNALRTGERP
0 10 Y379-p PDGMPVIyHGHtLtt
0 1 T383-p PVIyHGHtLttKIKF
0 1 T385-p IyHGHtLttKIKFSD
0 1 T386-p yHGHtLttKIKFSDV
0 1 K389 HtLttKIKFSDVLHT
0 1 S412 SEYPVILSIEDHCSI
0 6 H428 QQRNMAQHFRkVLGD
0 3 K431-u NMAQHFRkVLGDTLL
0 3 K440-u LGDTLLTkPVDIAAD
0 9 S470 HKKLAEGSAyEEVPT
2 132 Y472-p KLAEGSAyEEVPTSV
0 1 T477 SAyEEVPTSVMySEN
0 81 Y481-p EVPTSVMySENDISN
0 3 Y496-p SIKNGILyLEDPVNH
0 31 Y506-p DPVNHEWyPHyFVLT
3 8 Y509-p NHEWyPHyFVLTSSK
0 4 Y518 VLTSSKIYYSEETSS
0 1 Y669 AHESKEWYHASLTRA
0 10 Y702 KRNEPNSYAISFRAE
0 2 T766 EALEKIGTAEPDyGA
0 1 D770 KIGTAEPDyGALyEG
11 564 Y771-p IGTAEPDyGALyEGR
2 391 Y775-p EPDyGALyEGRNPGF
56 556 Y783-p EGRNPGFyVEANPMP
0 1 T791 VEANPMPTFKCAVKA
0 7 Y833 GGWWRGDYGGKKQLW
0 2 K941-u DARLTEGkMMERRKK
0 1 S954 KKIALELSELVVYCR
0 35 Y959 ELSELVVYCRPVPFD
0 672 Y977-p IGTERACyRDMSSFP
0 3 S981 RACyRDMSSFPETKA
0 1 S982 ACyRDMSSFPETKAE
0 7 Y991 PETKAEKYVNKAKGK
0 24 Y1003 KGKKFLQYNRLQLSR
0 1 K1215-u KIDIFPAkENGDLsP
0 64 S1221-p AkENGDLsPFsGIsL
0 4 S1224-p NGDLsPFsGIsLRER
0 5 I1226 DLsPFsGIsLRERAS
0 29 S1227-p LsPFsGIsLRERASD
0 31 S1233 IsLRERASDAsSQLF
0 6 S1236-p RERASDAsSQLFHVR
3 240 S1248-p HVRAREGsFEARyQQ
0 14 A1251 AREGsFEARyQQPFE
10 61 Y1253-p EGsFEARyQQPFEDF
0 53 S1263-p PFEDFRIsQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
  human

► Hide Isoforms 		 
Y93-p TSRDFDRyQEDPAFR
K178-u RISAKDLkNMLSQVN
Y186-p NMLSQVNyRVPNMRF
Y210-p QRSGDITyGQFAQLy
Y217-p yGQFAQLyRsLMYSA
S219-p QFAQLyRsLMYSAQk
K226-u sLMYSAQkTMDLPFL
T237-p LPFLEAStLRAGERP
Y379-p PDGMPVIyHGHTLTT
T383 PVIyHGHTLTTKIkF
T385 IyHGHTLTTKIkFSD
T386 yHGHTLTTKIkFSDV
K389-u HTLTTKIkFSDVLHT
S412-p SEYPVILsIEDHCSI
Y428-p QQRNMAQyFKkVLGD
K431-u NMAQyFKkVLGDTLL
K440-u LGDTLLTkPVEISAD
S470-p HKKLAEGsAyEEVPt
Y472-p KLAEGsAyEEVPtSM
T477-p sAyEEVPtSMMySEN
Y481-p EVPtSMMySENDISN
Y496-p SIKNGILyLEDPVNH
Y506-p DPVNHEWyPHyFVLT
Y509-p NHEWyPHyFVLTSSK
Y518-p VLTSSKIyYSEETSS
Y669-p AHESKEWyHASLTRA
Y702-p KRNEPNSyAISFRAE
T766-p EALEKIGtAEPdyGA
D770-ca KIGtAEPdyGALyEG
Y771-p IGtAEPdyGALyEGR
Y775-p EPdyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
T791-p VEANPMPtFKCAVKA
Y833-p GGWWRGDyGGKKQLW
K941-u DARLTEGkIMERRKK
S954-p KKIALELsELVVyCR
Y959-p ELsELVVyCRPVPFD
Y977-p IGTERACyRDMssFP
S981-p RACyRDMssFPETKA
S982-p ACyRDMssFPETKAE
Y991-p PETKAEKyVNKAKGK
Y1003-p KGKKFLQyNRLQLSR
K1215 KIDIFPAKENGDLsP
S1221-p AKENGDLsPFsGtsL
S1224-p NGDLsPFsGtsLRER
T1226-p DLsPFsGtsLRERGs
S1227-p LsPFsGtsLRERGsD
S1233-p tsLRERGsDAsGQLF
S1236-p RERGsDAsGQLFHGR
S1248-p HGRAREGsFEsRyQQ
S1251-p AREGsFEsRyQQPFE
Y1253-p EGsFEsRyQQPFEDF
S1263-p PFEDFRIsQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
  PLCG1 iso2  
Y93 TSRDFDRYQEDPAFR
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRSGDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
S219 QFAQLYRSLMYSAQK
K226 SLMYSAQKTMDLPFL
T237 LPFLEASTLRAGERP
Y379 PDGMPVIYHGHTLTT
T383 PVIYHGHTLTTKIKF
T385 IYHGHTLTTKIKFSD
T386 YHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
S412 SEYPVILSIEDHCSI
Y428 QQRNMAQYFKKVLGD
K431 NMAQYFKKVLGDTLL
K440 LGDTLLTKPVEISAD
S470 HKKLAEGSAYEEVPT
Y472 KLAEGSAYEEVPTSM
T477 SAYEEVPTSMMYSEN
Y481 EVPTSMMYSENDISN
Y496 SIKNGILYLEDPVNH
Y506 DPVNHEWYPHYFVLT
Y509 NHEWYPHYFVLTSSK
Y518 VLTSSKIYYSEETSS
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDYGA
D770 KIGTAEPDYGALYEG
Y771 IGTAEPDYGALYEGR
Y775 EPDYGALYEGRNPGF
Y783 EGRNPGFYVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKIMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977 IGTERACYRDMSSFP
S981 RACYRDMSSFPETKA
S982 ACYRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDIFPAKQENGDLs
S1222-p KQENGDLsPFsGtsL
S1225-p NGDLsPFsGtsLRER
T1227-p DLsPFsGtsLRERGs
S1228-p LsPFsGtsLRERGsD
S1234-p tsLRERGsDAsGQLF
S1237-p RERGsDAsGQLFHGR
S1249 HGRAREGSFESRYQQ
S1252 AREGSFESRYQQPFE
Y1254 EGSFESRYQQPFEDF
S1264 PFEDFRISQEHLADH
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
  rat

 
Y93 TSRDFDRYQEDPAFR
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRSGDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
S219 QFAQLYRSLMYSAQK
K226 SLMYSAQKTMDLPFL
T237 LPFLETNTLRTGERP
Y379-p PDGMPVIyHGHTLTT
T383 PVIyHGHTLTTKIKF
T385 IyHGHTLTTKIKFSD
T386 yHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
S412 SEYPVILSIEDHCSI
H428 QQRNMAQHFRKVLGD
K431 NMAQHFRKVLGDTLL
K440 LGDTLLTKPVDIAAD
S470 HKKLAEGSAYEEVPT
Y472 KLAEGSAYEEVPTSV
T477 SAYEEVPTSVMySEN
Y481-p EVPTSVMySENDISN
Y496 SIKNGILYLEDPVNH
Y506-p DPVNHEWyPHyFVLT
Y509-p NHEWyPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771-p IGTAEPDyGALyEGR
Y775-p EPDyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKMMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977-p IGTERACyRDMSSFP
S981 RACyRDMSSFPETKA
S982 ACyRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDIFPAKENGDLSP
S1221 AKENGDLSPFSGTSL
S1224 NGDLSPFSGTSLRER
T1226 DLSPFSGTSLRERAS
S1227 LSPFSGTSLRERASD
S1233 TSLRERASDASSQLF
S1236 RERASDASSQLFHVR
S1248 HVRAREGSFEARyQQ
A1251 AREGSFEARyQQPFE
Y1253-p EGSFEARyQQPFEDF
S1263 PFEDFRISQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
  cow

 
Y93 TSRDFDRYQEDPAFR
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRTSDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
S219 QFAQLYRSLMYSAQK
K226 SLMYSAQKTMDLPFL
A237 LPFLEASALRAGERP
Y379 PDGMPVIYHGHTLTT
T383 PVIYHGHTLTTKIKF
T385 IYHGHTLTTKIKFSD
T386 YHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
S412 SEYPVILSIEDHCSI
Y428 QQRNMAQYFKKVLGD
K431 NMAQYFKKVLGDTLL
K440 LGDTLLTKPVDIAAD
S470 HKKLAEGSAyEEVPT
Y472-p KLAEGSAyEEVPTSV
T477 SAyEEVPTSVMYSEN
Y481 EVPTSVMYSENDISN
Y496 SIKNGILYLEDPVNH
Y506 DPVNHEWYPHyFVLT
Y509-p NHEWYPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771-p IGTAEPDyGALyEGR
Y775-p EPDyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKMMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977 IGTERACYRDMSSFP
S981 RACYRDMSSFPETKA
S982 ACYRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDVFPAKQENGDLS
S1222 KQENGDLSPFGGASL
G1225 NGDLSPFGGASLRER
A1227 DLSPFGGASLRERSC
S1228 LSPFGGASLRERSCD
C1234 ASLRERSCDASGPLF
S1237 RERSCDASGPLFHGR
S1249 HGRAREGSFEARyQQ
A1252 AREGSFEARyQQPFE
Y1254-p EGSFEARyQQPFEDF
S1264 PFEDFRISQEHLADH
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