Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ADRB1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ADRB1 a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1
Cellular Component: integral to plasma membrane; early endosome; plasma membrane; nucleus
Molecular Function: protein binding; protein heterodimerization activity; receptor signaling protein activity; dopamine binding; norepinephrine binding; drug binding; epinephrine binding; beta-adrenergic receptor activity; alpha-2A adrenergic receptor binding; Ras guanyl-nucleotide exchange factor activity; PDZ domain binding; beta1-adrenergic receptor activity
Biological Process: fear response; diet induced thermogenesis; wound healing; apoptosis; positive regulation of apoptosis; lipid homeostasis; positive regulation of systemic arterial blood pressure; sensory perception of pain; positive regulation of saliva secretion; Rho protein signal transduction; regulation of inhibitory postsynaptic membrane potential; positive regulation of Ras GTPase activity; negative regulation of smooth muscle contraction; positive regulation of cAMP biosynthetic process; aging; glycogen catabolic process; negative regulation of multicellular organism growth; adenylate cyclase activation; regulation of calcium ion transport; memory; positive regulation of the force of heart contraction by norepinephrine; protein localization in organelle; heat generation; brown fat cell differentiation; response to cold; positive regulation of heart rate by epinephrine-norepinephrine; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure
Reference #:  P08588 (UniProtKB)
Alt. Names/Synonyms: ADRB1; ADRB1R; adrenergic, beta-1-, receptor; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; BETA1AR; RHR
Gene Symbols: ADRB1
Molecular weight: 51,323 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ADRB1

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
molecular association, regulation: S312‑p
receptor desensitization, altered: S312‑p
receptor recycling, altered: S312‑p
receptor recycling, induced: S312‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y157-p CVIALDRyLAITSPF
0 1 T181 RARGLVCTVWAISAL
0 1 S186 VCTVWAISALVSFLP
5 0 S312-p RAGKRRPsRLVALRE
0 2 R357-m2 HRELVPDrLFVFFNW
0 1 S423 ARPGPPPSPGAASDD
0 2 S428 PPSPGAASDDDDDDV
1 0 S475-p RPGFASEsKV_____
  mouse

 
Y157 CVIALDRYLAITSPF
T181-p RARALVCtVWAIsAL
S186-p VCtVWAIsALVSFLP
S301 RSSKRRPSRLVALRE
R346 HRDLVPDRLFVFFNW
S412-p ARAGPPPsPGAPsDD
S417-p PPsPGAPsDDDDDDA
S464 RQGFSSESKV_____
  rat

 
Y157 CVIALDRYLAITLPF
T181 RARALVCTVWAISAL
S186 VCTVWAISALVSFLP
S301 RSSKRRPSRLVALRE
R346 HRDLVPDRLFVFFNW
S412 ARAGPPPSPGAPSDD
S417 PPSPGAPSDDDDDDA
S464 RQGFSSESKV_____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.