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Protein Page:
PPP1CA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PPP1CA is a catalytic subunit of protein phosphatase 1 (PP1), aubiquitous cytosolic serine-threonine phosphatase. Composed of a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer's disease. Down-regulated in lung squamous cell carcinoma. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)
Cellular Component: glycogen granule; cytoplasm; nucleolus; dendritic spine; perikaryon; protein phosphatase type 1 complex; nucleus; cytosol
Molecular Function: ribonucleoprotein binding; protein binding; metal ion binding; phosphoric monoester hydrolase activity; protein serine/threonine phosphatase activity
Biological Process: glycogen metabolic process; regulation of glycogen catabolic process; branching morphogenesis of a tube; cell division; transforming growth factor beta receptor signaling pathway; triacylglycerol catabolic process; regulation of glycogen biosynthetic process; circadian regulation of gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of circadian rhythm; protein amino acid dephosphorylation; cell cycle; lung development; entrainment of circadian clock by photoperiod
Reference #:  P62136 (UniProtKB)
Alt. Names/Synonyms: MGC15877; MGC1674; PP-1A; PP1A; PP1alpha; PPP1A; PPP1CA; protein phosphatase 1, catalytic subunit, alpha isoform; protein phosphatase 1, catalytic subunit, alpha isozyme; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Gene Symbols: PPP1CA
Molecular weight: 37,512 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  Parkinson's Disease  |  Translation: eIF2
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPP1CA

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, altered: T320‑p
activity, inhibited: T320‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2-p ______MsDSEKLNL
0 1 S4 ____MsDSEKLNLDs
0 3 S11-p SEKLNLDsIIGRLLE
0 2 S22-p RLLEVQGsRPGkNVQ
0 17 K26-ub VQGsRPGkNVQLTEN
0 2 S48 KSREIFLSQPILLEL
0 2 K60-ub LELEAPLkICGDIHG
0 22 K98-ub GDYVDRGkQSLETIC
0 3 K113-ub LLLAYKIkYPENFFL
0 3 Y134-p CASINRIyGFyDECk
0 23 Y137-p INRIyGFyDECkRRY
0 19 K141-ac yGFyDECkRRYNIkL
0 14 K141-ub yGFyDECkRRYNIkL
0 3 K147-ub CkRRYNIkLWkTFTD
0 4 K150-ub RYNIkLWkTFTDCFN
0 6 K260-ac DGYEFFAkRQLVTLF
0 34 K260-ub DGYEFFAkRQLVTLF
0 2 K305-ac PADKNKGkyGQFsGL
0 5 K305-ub PADKNKGkyGQFsGL
0 48 Y306-p ADKNKGkyGQFsGLN
0 2 S310-p KGkyGQFsGLNPGGR
18 102 T320-p NPGGRPItPPRNsAK
1 10 S325-p PItPPRNsAKAKK__
2581 : Phospho-PP1alpha (Thr320) Antibody
  mouse

 
S2-p ______MsDsEKLNL
S4-p ____MsDsEKLNLDS
S11 sEKLNLDSIIGRLLE
S22 RLLEVQGSRPGkNVQ
K26-ub VQGSRPGkNVQLTEN
S48-p KSREIFLsQPILLEL
K60 LELEAPLKICGDIHG
K98-ub GDYVDRGkQSLETIC
R113 LLLAYKIRYPENFFL
Y134 CASINRIYGFyDECk
Y137-p INRIYGFyDECkRRY
K141-ac YGFyDECkRRYNIkL
K141-ub YGFyDECkRRYNIkL
K147-ub CkRRYNIkLWkTFTD
K150-ub RYNIkLWkTFTDCFN
K260-ac DGYEFFAkRQLVTLF
K260-ub DGYEFFAkRQLVTLF
K305 PADKNKGKYGQFSGL
K305-ub PADKNKGkYGQFSGL
Y306 ADKNKGkYGQFSGLN
S310 KGkYGQFSGLNPGGR
T320-p NPGGRPItPPRNsAK
S325-p PItPPRNsAKAKK__
  rat

 
S2 ______MSDSEKLNL
S4 ____MSDSEKLNLDS
S11 SEKLNLDSIIGRLLE
S22 RLLEVQGSRPGKNVQ
K26 VQGSRPGKNVQLTEN
S48-p KSREIFLsQPILLEL
K60 LELEAPLKICGDIHG
K98 GDYVDRGKQSLETIC
K113 LLLAYKIKYPENFFL
Y134-p CASINRIyGFYDECK
Y137 INRIyGFYDECKRRY
K141 yGFYDECKRRYNIKL
K141 yGFYDECKRRYNIKL
K147 CKRRYNIKLWKTFTD
K150 RYNIKLWKTFTDCFN
K260 DGYEFFAKRQLVTLF
K260 DGYEFFAKRQLVTLF
K305 PADKNKGKYGQFSGL
K305 PADKNKGKYGQFSGL
Y306 ADKNKGKYGQFSGLN
S310 KGKYGQFSGLNPGGR
T320-p NPGGRPItPPRNSAK
S325 PItPPRNSAKAKK__
  rabbit

 
S2 ______MSDSEKLNL
S4 ____MSDSEKLNLDS
S11 SEKLNLDSIIGRLLE
S22 RLLEVQGSRPGKNVQ
K26 VQGSRPGKNVQLTEN
S48 KSREIFLSQPILLEL
K60 LELEAPLKICGDIHG
K98 GDYVDRGKQSLETIC
K113 LLLAYKIKYPENFFL
Y134 CASINRIYGFYDECK
Y137 INRIYGFYDECKRRY
K141 YGFYDECKRRYNIKL
K141 YGFYDECKRRYNIKL
K147 CKRRYNIKLWKTFTD
K150 RYNIKLWKTFTDCFN
K260 DGYEFFAKRQLVTLF
K260 DGYEFFAKRQLVTLF
K305 PADKNKGKYGQFSGL
K305 PADKNKGKYGQFSGL
Y306 ADKNKGKYGQFSGLN
S310 KGKYGQFSGLNPGGR
T320-p NPGGRPItPPRNsAK
S325-p PItPPRNsAKAKK__
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