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PPP1CA (human)

Overview PPP1CA is a catalytic subunit of protein phosphatase 1 (PP1), aubiquitous cytosolic serine-threonine phosphatase. Composed of a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer's disease. Down-regulated in lung squamous cell carcinoma. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) Cellular Component: glycogen granule; cytoplasm; dendritic spine; nucleolus; perikaryon; protein phosphatase type 1 complex; nucleus; cytosol Molecular Function: ribonucleoprotein binding; protein binding; metal ion binding; protein serine/threonine phosphatase activity Biological Process: glycogen metabolic process; regulation of glycogen catabolic process; branching morphogenesis of a tube; cell division; transforming growth factor beta receptor signaling pathway; regulation of glycogen biosynthetic process; triacylglycerol catabolic process; lipid metabolic process; cell cycle; protein amino acid dephosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; lung development Reference #:  P62136 (UniProtKB) Alt. Names/Synonyms: MGC15877; MGC1674; PP-1A; PP1A; PP1alpha; PPP1A; PPP1CA; protein phosphatase 1, catalytic subunit, alpha isoform; protein phosphatase 1, catalytic subunit, alpha isozyme; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Gene Symbols: PPP1CA Molecular weight: 37,512 Da Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  Parkinson's Disease  |  Translation: eIF2 Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PPP1CA 3E7A - A/B=7-300 (human) 3E7B - A/B=7-300 (human) 3EGG - A/B=7-330 (human) 3EGH - A/B=7-330 (human) 3HVQ - A/B=7-330 (human) 3N5U - A/B=1-300 (human) 3V4Y - A/C/G/E=7-307 (human) 4G9J - A/B=1-330 (human) 1FJM - A/B=1-330 (rabbit)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell differentiation, altered: T320‑p inhibition: T320‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S2	______MSDSEKLNL
0	1		S4	____MSDSEKLNLDs
0	2		S11-p	SEKLNLDsIIGRLLE
0	1		S22-p	RLLEVQGsRPGkNVQ
0	17		K26-u	VQGsRPGkNVQLTEN
0	2		S48-p	KSREIFLsQPILLEL
0	2		K60-u	LELEAPLkICGDIHG
0	22		K98-u	GDYVDRGkQSLETIC
0	3		K113-u	LLLAYKIkYPENFFL
0	3		Y134-p	CASINRIyGFyDECk
0	23		Y137-p	INRIyGFyDECkRRY
0	18		K141-a	yGFyDECkRRYNIkL
0	14		K141-u	yGFyDECkRRYNIkL
0	3		K147-u	CkRRYNIkLWkTFTD
0	4		K150-u	RYNIkLWkTFTDCFN
0	5		K260-a	DGYEFFAkRQLVTLF
0	34		K260-u	DGYEFFAkRQLVTLF
0	2		K305-a	PADKNKGkyGQFSGL
0	5		K305-u	PADKNKGkyGQFSGL
0	48		Y306-p	ADKNKGkyGQFSGLN
16	98		T320-p	NPGGRPItPPRNsAK
1	7		S325-p	PItPPRNsAKAKK__

	mouse
S2-p	______MsDsEKLNL
S4-p	____MsDsEKLNLDS
S11	sEKLNLDSIIGRLLE
S22	RLLEVQGSRPGkNVQ
K26-u	VQGSRPGkNVQLTEN
S48-p	KSREIFLsQPILLEL
K60	LELEAPLKICGDIHG
K98-u	GDYVDRGkQSLETIC
R113	LLLAYKIRYPENFFL
Y134	CASINRIYGFyDECk
Y137-p	INRIYGFyDECkRRY
K141-a	YGFyDECkRRYNIkL
K141-u	YGFyDECkRRYNIkL
K147-u	CkRRYNIkLWkTFTD
K150-u	RYNIkLWkTFTDCFN
K260-a	DGYEFFAkRQLVTLF
K260-u	DGYEFFAkRQLVTLF
K305	PADKNKGKYGQFSGL
K305-u	PADKNKGkYGQFSGL
Y306	ADKNKGkYGQFSGLN
T320-p	NPGGRPItPPRNsAK
S325-p	PItPPRNsAKAKK__

	rat
S2	______MSDSEKLNL
S4	____MSDSEKLNLDS
S11	SEKLNLDSIIGRLLE
S22	RLLEVQGSRPGKNVQ
K26	VQGSRPGKNVQLTEN
S48-p	KSREIFLsQPILLEL
K60	LELEAPLKICGDIHG
K98	GDYVDRGKQSLETIC
K113	LLLAYKIKYPENFFL
Y134-p	CASINRIyGFYDECK
Y137	INRIyGFYDECKRRY
K141	yGFYDECKRRYNIKL
K141	yGFYDECKRRYNIKL
K147	CKRRYNIKLWKTFTD
K150	RYNIKLWKTFTDCFN
K260	DGYEFFAKRQLVTLF
K260	DGYEFFAKRQLVTLF
K305	PADKNKGKYGQFSGL
K305	PADKNKGKYGQFSGL
Y306	ADKNKGKYGQFSGLN
T320-p	NPGGRPItPPRNSAK
S325	PItPPRNSAKAKK__

	rabbit
S2	______MSDSEKLNL
S4	____MSDSEKLNLDS
S11	SEKLNLDSIIGRLLE
S22	RLLEVQGSRPGKNVQ
K26	VQGSRPGKNVQLTEN
S48	KSREIFLSQPILLEL
K60	LELEAPLKICGDIHG
K98	GDYVDRGKQSLETIC
K113	LLLAYKIKYPENFFL
Y134	CASINRIYGFYDECK
Y137	INRIYGFYDECKRRY
K141	YGFYDECKRRYNIKL
K141	YGFYDECKRRYNIKL
K147	CKRRYNIKLWKTFTD
K150	RYNIKLWKTFTDCFN
K260	DGYEFFAKRQLVTLF
K260	DGYEFFAKRQLVTLF
K305	PADKNKGKYGQFSGL
K305	PADKNKGKYGQFSGL
Y306	ADKNKGKYGQFSGLN
T320-p	NPGGRPItPPRNsAK
S325-p	PItPPRNsAKAKK__

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