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Protein Page:
Ig-alpha (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Ig-alpha an integral membrane protein that associates with surface immunoglobulin B lymphocyte antigen receptor multimeric complex. Surface Ig non-covalently associates with 2 other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Cellular Component: multivesicular body; integral to membrane; plasma membrane; B cell receptor complex; lipid raft; external side of plasma membrane
Molecular Function: transmembrane receptor activity
Biological Process: B cell proliferation; B cell receptor signaling pathway; B cell activation; B cell differentiation
Reference #:  P11912 (UniProtKB)
Alt. Names/Synonyms: B-cell antigen receptor complex-associated protein alpha chain; CD79A; CD79A antigen; CD79a antigen (immunoglobulin-associated alpha); CD79a molecule, immunoglobulin-associated alpha; Ig-alpha; IGA; MB-1; MB-1 membrane glycoprotein; MB1; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein
Gene Symbols: CD79A
Molecular weight: 25,038 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ig-alpha

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y210‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T140-p FLDMGEGtkNRIITA
0 7 K141-ub LDMGEGtkNRIITAE
0 1 T161-p FCAVVPGtLLLFRKR
0 1 K173-ub RKRWQNEkLGLDAGD
5 6 Y182-p GLDAGDEyEDENLyE
3 14 Y188-p EyEDENLyEGLNLDD
1 4 S197-p GLNLDDCsMyEDISR
3 26 Y199-p NLDDCsMyEDISRGL
3 0 S203 CsMyEDISRGLQGTy
1 0 T209 ISRGLQGTyQDVGSL
6 34 Y210-p SRGLQGTyQDVGSLN
0 3 K225-ub IGDVQLEkP______
5173 : Phospho-CD79A (Tyr182) Antibody
  mouse

 
T134 FLDMGEGTKNRIITA
K135 LDMGEGTKNRIITAE
T155 FCAVVPGTLLLFRKR
K167 RKRWQNEKFGVDMPD
Y176-p GVDMPDDyEDENLyE
Y182-p DyEDENLyEGLNLDD
S191-p GLNLDDCsMyEDIsR
Y193-p NLDDCsMyEDIsRGL
S197-p CsMyEDIsRGLQGty
T203-p IsRGLQGtyQDVGNL
Y204-p sRGLQGtyQDVGNLH
K219-ub IGDAQLEkP______
5173 : Phospho-CD79A (Tyr182) Antibody
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