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Ig-alpha (human)

Overview Ig-alpha an integral membrane protein that associates with surface immunoglobulin B lymphocyte antigen receptor multimeric complex. Surface Ig non-covalently associates with 2 other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Immunoglobulin superfamily; Membrane protein, integral Cellular Component: multivesicular body; integral to membrane; plasma membrane; B cell receptor complex; external side of plasma membrane; lipid raft Molecular Function: transmembrane receptor activity Biological Process: B cell proliferation; B cell receptor signaling pathway; B cell activation; B cell differentiation Reference #:  P11912 (UniProtKB) Alt. Names/Synonyms: B-cell antigen receptor complex-associated protein alpha chain; CD79A; CD79A antigen; CD79a antigen (immunoglobulin-associated alpha); CD79a molecule, immunoglobulin-associated alpha; Ig-alpha; IGA; MB-1; MB-1 membrane glycoprotein; MB1; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein Gene Symbols: CD79A Molecular weight: 25,038 Da Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Ig-alpha

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		T140-p	FLDMGEGtkNRIITA
0	7		K141-u	LDMGEGtkNRIITAE
0	1		T161-p	FCAVVPGtLLLFRKR
0	1		K173-u	RKRWQNEkLGLDAGD
4	5		Y182-p	GLDAGDEyEDENLyE
3	14		Y188-p	EyEDENLyEGLNLDD
1	4		S197-p	GLNLDDCsMyEDISR
3	27		Y199-p	NLDDCsMyEDISRGL
3	0		S203	CsMyEDISRGLQGTy
1	0		T209	ISRGLQGTyQDVGSL
5	34		Y210-p	SRGLQGTyQDVGSLN
0	3		K225-u	IGDVQLEkP______

	mouse
T134	FLDMGEGTKNRIITA
K135	LDMGEGTKNRIITAE
T155	FCAVVPGTLLLFRKR
K167	RKRWQNEKFGVDMPD
Y176-p	GVDMPDDyEDENLyE
Y182-p	DyEDENLyEGLNLDD
S191-p	GLNLDDCsMyEDIsR
Y193-p	NLDDCsMyEDIsRGL
S197-p	CsMyEDIsRGLQGty
T203-p	IsRGLQGtyQDVGNL
Y204-p	sRGLQGtyQDVGNLH
K219-u	IGDAQLEkP______

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