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Protein Page:
AMPKG2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AMPKG2 AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non- catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. Isoform B is ubiquitously expressed except in liver and thymus. The highest level is detected in heart with abundant expression in placenta and testis. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit; Autophagy
Cellular Component: nucleoplasm; extracellular space; cytosol; AMP-activated protein kinase complex
Molecular Function: cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; ADP binding; phosphorylase kinase regulator activity; protein kinase binding; protein kinase activator activity; ATP binding; AMP binding
Biological Process: glycogen metabolic process; carnitine shuttle; cellular lipid metabolic process; regulation of fatty acid biosynthetic process; regulation of glycolysis; ATP biosynthetic process; positive regulation of protein kinase activity; sterol biosynthetic process; regulation of fatty acid metabolic process; insulin receptor signaling pathway; energy reserve metabolic process; regulation of fatty acid oxidation; negative regulation of protein kinase activity; regulation of glucose import; cell cycle arrest; fatty acid biosynthetic process
Reference #:  Q9UGJ0 (UniProtKB)
Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit gamma-2; AAKG; AAKG2; AMPK gamma2; AMPK subunit gamma-2; CMH6; H91620p; PRKAG2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; WPWS
Gene Symbols: PRKAG2
Molecular weight: 63,066 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AMPKG2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 5 S32-p NASQKRRsLRVHIPD
0 1 K62-m1 SGKHSSRkVDsPFGP
0 23 S65-p HSSRkVDsPFGPGsP
0 1 G68 RkVDsPFGPGsPsKG
0 1 P69 kVDsPFGPGsPsKGF
0 14 S71-p DsPFGPGsPsKGFFS
0 5 S73-p PFGPGsPsKGFFSRG
0 1 S78 sPsKGFFSRGPQPRP
0 2 S86-p RGPQPRPssPMsAPV
0 5 S87-p GPQPRPssPMsAPVR
0 5 S90-p PRPssPMsAPVRPKt
0 2 T97-p sAPVRPKtsPGsPKT
0 1 S98-p APVRPKtsPGsPKTV
0 3 S101-p RPKtsPGsPKTVFPF
0 1 Y110 KTVFPFSYQESPPRS
0 6 S113 FPFSYQESPPRSPRR
0 6 S117 YQESPPRSPRRMsFS
0 6 S122-p PRSPRRMsFSGIFRS
0 2 S124 SPRRMsFSGIFRSSs
0 2 S131-p SGIFRSSsKESsPNS
0 1 S134 FRSSsKESsPNSNPA
0 4 S135-p RSSsKESsPNSNPAt
0 2 S138 sKESsPNSNPAtsPG
0 2 T142-p sPNSNPAtsPGGIRF
0 7 S143-p PNSNPAtsPGGIRFF
0 2 S151-p PGGIRFFsRsRKtsG
0 2 S153-p GIRFFsRsRKtsGLs
0 4 T156-p FFsRsRKtsGLsSsP
0 2 S157-p FsRsRKtsGLsSsPs
0 3 G158 sRsRKtsGLsSsPst
0 2 S160-p sRKtsGLsSsPstPt
0 4 S161 RKtsGLsSsPstPtQ
0 10 S162-p KtsGLsSsPstPtQV
0 1 S164-p sGLsSsPstPtQVTK
0 5 T165-p GLsSsPstPtQVTKQ
0 1 T167-p sSsPstPtQVTKQHT
0 1 Y180-p HTFPLESyKHEPERL
0 12 S196-p NRIYASSsPPDTGQR
0 7 S211-p FCPSSFQsPTRPPLA
0 4 S219 PTRPPLASPTHyAPS
0 1 Y223-p PLASPTHyAPSKAAA
0 1 S309-p RAAPLWEsKKQSFVG
  AMPKG2 iso4  
S6-p __MKRFGsLRSNKKH
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S36 GLFASGLSSSPSTPT
S37 LFASGLSSSPSTPTQ
S38 FASGLSSSPSTPTQV
S40 SGLSSSPSTPTQVTK
T41 GLSSSPSTPTQVTKQ
T43 SSSPSTPTQVTKQHT
Y56 HTFPLESYKHEPERL
S72 NRIYASSSPPDTGQR
S87 FCPSSFQSPTRPPLA
S95 PTRPPLASPTHYAPS
Y99 PLASPTHYAPSKAAA
S185 RAAPLWESKKQSFVG
  mouse

 
- gap
S32-p NPSLKRRsLRVHIPD
K62 SEKHSSRKVDsPFss
S65-p HSSRKVDsPFssGsP
S68-p RKVDsPFssGsPsRG
S69-p KVDsPFssGsPsRGL
S71-p DsPFssGsPsRGLFs
S73-p PFssGsPsRGLFsRG
S78-p sPsRGLFsRGPQPRP
S86-p RGPQPRPssPVsAPV
S87-p GPQPRPssPVsAPVR
S90-p PRPssPVsAPVRPKt
T97-p sAPVRPKtSPGsPKT
S98 APVRPKtSPGsPKTV
S101-p RPKtSPGsPKTVFPF
Y110-p KTVFPFSyQEsPPRs
S113-p FPFSyQEsPPRsPRR
S117-p yQEsPPRsPRRMsFs
S122-p PRsPRRMsFsGIFRS
S124-p sPRRMsFsGIFRSSs
S131-p sGIFRSSsKEssPNs
S134-p FRSSsKEssPNsNPS
S135-p RSSsKEssPNsNPSt
S138-p sKEssPNsNPStsPG
T142-p sPNsNPStsPGGIRF
S143-p PNsNPStsPGGIRFF
S151 PGGIRFFSRSRKTss
S153 GIRFFSRSRKTssVs
T156 FFSRSRKTssVsssP
S157-p FSRSRKTssVsssPs
S158-p SRSRKTssVsssPst
S160-p SRKTssVsssPstPT
S161-p RKTssVsssPstPTQ
S162-p KTssVsssPstPTQV
S164-p ssVsssPstPTQVTK
T165-p sVsssPstPTQVTKQ
T167 sssPstPTQVTKQHP
Y180 HPFPLESYKQEPERP
S196-p SRIYASSsPPDTGQR
S210-p RFCLAFQsPARPPLA
S218-p PARPPLAsPTYHAPL
H222 PLAsPTYHAPLRTAV
S306 RAAPLWESKKQSFVG
  rat

 
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S4 ____RRMSFSGIFRS
S6 __RRMSFSGIFRSSS
S13 SGIFRSSSKESSPNS
S16 FRSSSKESSPNSNPS
S17 RSSSKESSPNSNPST
S20 SKESSPNSNPSTSPG
T24 SPNSNPSTSPGGIRF
S25 PNSNPSTSPGGIRFF
S33 PGGIRFFSRSRKTSS
S35 GIRFFSRSRKTSSVS
T38 FFSRSRKTSSVSSSP
S39 FSRSRKTSSVSSSPS
S40 SRSRKTSSVSSSPST
S42 SRKTSSVSSSPSTPT
S43 RKTSSVSSSPSTPTQ
S44 KTSSVSSSPSTPTQV
S46 SSVSSSPSTPTQVTK
T47 SVSSSPSTPTQVTKQ
T49 SSSPSTPTQVTKQHP
Y62 HPFPLESYKQEPERL
S78-p SRIYASSsPPDTGQR
S92 RFCLAFQSPVRLPLA
S100 PVRLPLASPTHHAPL
H104 PLASPTHHAPLRTAA
S188 RAAPLWESKKQSFVG
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