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AMPKG2
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non- catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. Isoform B is ubiquitously expressed except in liver and thymus. The highest level is detected in heart with abundant expression in placenta and testis. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Kinase, protein; Autophagy; Protein kinase, regulatory subunit |
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Cellular Component: nucleoplasm; cytosol; AMP-activated protein kinase complex
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Molecular Function: AMP-activated protein kinase activity; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; phosphorylase kinase regulator activity; ADP binding; protein kinase binding; protein kinase activator activity; ATP binding; AMP binding
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Biological Process: glycogen metabolic process; protein kinase cascade; carnitine shuttle; cellular lipid metabolic process; regulation of fatty acid biosynthetic process; sterol biosynthetic process; positive regulation of protein kinase activity; regulation of glycolysis; ATP biosynthetic process; regulation of fatty acid metabolic process; regulation of fatty acid oxidation; insulin receptor signaling pathway; energy reserve metabolic process; negative regulation of protein kinase activity; regulation of glucose import; cell cycle arrest; fatty acid biosynthetic process
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Reference #:
Q9UGJ0 (UniProtKB)
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| Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit gamma-2; AAKG; AAKG2; AMPK gamma2; AMPK subunit gamma-2; CMH6; H91620p; PRKAG2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; WPWS |
| Gene Symbols: PRKAG2 |
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Molecular weight: 63,066 Da
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Basal Isoelectric point: 9.37
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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