ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis
Cellular Component: microtubule cytoskeleton; spindle pole; protein phosphatase type 2A complex; membrane; mitochondrion; plasma membrane; cytosol; nucleus; chromosome, pericentric region
Molecular Function: protein C-terminus binding; protein dimerization activity; protein binding; metal ion binding; protein serine/threonine phosphatase activity
Biological Process: meiosis; mitotic nuclear envelope reassembly; apoptosis; regulation of protein amino acid autophosphorylation; protein amino acid dephosphorylation; response to organic substance; regulation of transcription, DNA-dependent; RNA metabolic process; regulation of cell differentiation; regulation of growth; mesoderm development; regulation of receptor activity; inactivation of MAPK activity; regulation of DNA replication; second-messenger-mediated signaling; regulation of cell adhesion; fibroblast growth factor receptor signaling pathway; RNA splicing; regulation of Wnt receptor signaling pathway; mRNA metabolic process; negative regulation of tyrosine phosphorylation of Stat3 protein; mRNA catabolic process, nonsense-mediated decay; regulation of protein catabolic process; gene expression; mitotic cell cycle; negative regulation of cell growth; ceramide metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.