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PPP2CA (human)

Overview PPP2CA ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Note: This description may include information from UniProtKB. Protein type: Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.16 Cellular Component: microtubule cytoskeleton; spindle pole; protein phosphatase type 2A complex; mitochondrion; membrane; plasma membrane; cytosol; nucleus; chromosome, pericentric region Molecular Function: protein dimerization activity; protein C-terminus binding; protein binding; metal ion binding; phosphoprotein phosphatase activity Biological Process: meiosis; regulation of protein amino acid autophosphorylation; protein amino acid dephosphorylation; response to organic substance; regulation of transcription, DNA-dependent; RNA metabolic process; regulation of cell differentiation; regulation of growth; mesoderm development; regulation of receptor activity; inactivation of MAPK activity; regulation of DNA replication; second-messenger-mediated signaling; regulation of cell adhesion; fibroblast growth factor receptor signaling pathway; RNA splicing; regulation of Wnt receptor signaling pathway; mRNA metabolic process; induction of apoptosis; negative regulation of tyrosine phosphorylation of Stat3 protein; mRNA catabolic process, nonsense-mediated decay; gene expression; regulation of protein catabolic process; negative regulation of cell growth; ceramide metabolic process Reference #:  P67775 (UniProtKB) Alt. Names/Synonyms: PP2A-alpha; PP2AA; PP2Ac; PP2CA; PP2Calpha; PPP2CA; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2A catalytic subunit, alpha isoform; Replication protein C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Gene Symbols: PPP2CA Molecular weight: 35,594 Da Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling  |  TGF-ß Signaling  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PPP2CA 2IAE - C/F=1-309 (human) 2IE3 - C=1-309 (human) 2IE4 - C=1-309 (human) 2NPP - C/F=1-309 (human) 2NYL - C/F=2-294 (human) 2NYM - C/F=2-294 (human) 3C5W - C=1-309 (human) 3DW8 - F/C=1-309 (human) 3FGA - C=1-309 (human) 3K7V - C=1-309 (human) 3K7W - C=1-309 (human) 3P71 - C=1-309 (human) 4I5L - F/C=1-309 (human) 4I5N - F/C=1-309 (human) 4IYP - A=2-234 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: Y307‑p cell growth, altered: T304‑p, Y307‑p cytoskeletal reorganization: T304‑p, Y307‑p enzymatic activity, induced: L309‑m enzymatic activity, inhibited: T304‑p, Y307‑p intracellular localization: Y307‑p methylation: Y307‑p molecular association, regulation: T304‑p, Y307‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K4-a	____MDEkVFTkELD
0	76		K8-u	MDEkVFTkELDQWIE
0	126		K21-u	IEQLNECkQLSESQV
0	16		K29-u	QLSESQVkSLCEkAK
0	5		K34-u	QVkSLCEkAKEILTk
0	47		K41-u	kAKEILTkESNVQEV
0	10		K74-u	ELFRIGGkSPDTNYL
0	1		Y86-p	NYLFMGDyVDRGyyS
0	1		Y91-p	GDyVDRGyySVETVT
0	1		Y92-p	DyVDRGyySVETVTL
0	4		K136-u	FYDECLRkYGNANVW
0	4		Y248-p	HQLVMEGyNWCHDRN
0	7		Y265-p	TIFSAPNyCYRCGNQ
0	28		K283-u	MELDDTLkySFLQFD
0	19		Y284-p	ELDDTLkySFLQFDP
3	5		T304-p	EPHVTRRtPDyFl__
35	0		Y307-p	VTRRtPDyFl_____
4	0		L309-m	RRtPDyFl_______

	mouse
K4	____MDEKLFTkELD
K8-u	MDEKLFTkELDQWIE
K21-u	IEQLNECkQLSESQV
K29-u	QLSESQVkSLCEKAK
K34	QVkSLCEKAKEILTk
K41-u	KAKEILTkESNVQEV
K74-u	ELFRIGGkSPDTNYL
Y86	NYLFMGDYVDRGYYS
Y91	GDYVDRGYYSVETVT
Y92	DYVDRGYYSVETVTL
K136-u	FYDECLRkYGNANVW
Y248	HQLVMEGYNWCHDRN
Y265	TIFSAPNYCYRCGNQ
K283-u	MELDDTLkySFLQFD
Y284-p	ELDDTLkySFLQFDP
T304-p	EPHVTRRtPDyFl__
Y307-p	VTRRtPDyFl_____
L309-m	RRtPDyFl_______

	rat
K4	____MDEKLFTkELD
K8-u	MDEKLFTkELDQWIE
K21-u	IEQLNECkQLSESQV
K29	QLSESQVKSLCEKAK
K34	QVKSLCEKAKEILTk
K41-u	KAKEILTkESNVQEV
K74	ELFRIGGKSPDTNYL
Y86	NYLFMGDYVDRGYYS
Y91	GDYVDRGYYSVETVT
Y92	DYVDRGYYSVETVTL
K136	FYDECLRKYGNANVW
Y248-p	HQLVMEGyNWCHDRN
Y265	TIFSAPNYCYRCGNQ
K283-u	MELDDTLkySFLQFD
Y284-p	ELDDTLkySFLQFDP
T304-p	EPHVTRRtPDyFl__
Y307-p	VTRRtPDyFl_____
L309-m	RRtPDyFl_______

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