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Protein Page:
PPP2CA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PPP2CA ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: microtubule cytoskeleton; spindle pole; protein phosphatase type 2A complex; mitochondrion; membrane; plasma membrane; nucleus; cytosol; chromosome, pericentric region
Molecular Function: protein dimerization activity; protein C-terminus binding; protein binding; metal ion binding; protein serine/threonine phosphatase activity
Biological Process: meiosis; mitotic nuclear envelope reassembly; apoptosis; regulation of protein amino acid autophosphorylation; protein amino acid dephosphorylation; response to organic substance; regulation of transcription, DNA-dependent; RNA metabolic process; regulation of growth; regulation of cell differentiation; mesoderm development; regulation of receptor activity; regulation of DNA replication; inactivation of MAPK activity; second-messenger-mediated signaling; regulation of cell adhesion; fibroblast growth factor receptor signaling pathway; RNA splicing; regulation of Wnt receptor signaling pathway; mRNA metabolic process; negative regulation of tyrosine phosphorylation of Stat3 protein; mRNA catabolic process, nonsense-mediated decay; regulation of protein catabolic process; gene expression; negative regulation of cell growth; mitotic cell cycle; ceramide metabolic process
Reference #:  P67775 (UniProtKB)
Alt. Names/Synonyms: PP2A-alpha; PP2AA; PP2Ac; PP2CA; PP2Calpha; PPP2CA; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2A catalytic subunit, alpha isoform; Replication protein C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Gene Symbols: PPP2CA
Molecular weight: 35,594 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling  |  TGF-ß Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPP2CA

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y307‑p
cell growth, altered: T304‑p, Y307‑p
cytoskeletal reorganization: T304‑p, Y307‑p
enzymatic activity, induced: L309‑me
enzymatic activity, inhibited: T304‑p, Y307‑p
intracellular localization: Y307‑p
methylation: Y307‑p
molecular association, regulation: T304‑p, Y307‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K4-ac ____MDEkVFTkELD
0 76 K8-ub MDEkVFTkELDQWIE
0 126 K21-ub IEQLNECkQLSEsQV
0 1 S26-p ECkQLSEsQVkSLCE
0 16 K29-ub QLSEsQVkSLCEkAK
0 5 K34-ub QVkSLCEkAKEILTk
0 1 K41-ac kAKEILTkESNVQEV
0 47 K41-ub kAKEILTkESNVQEV
0 10 K74-ub ELFRIGGkSPDTNYL
0 4 K136-ub FYDECLRkYGNANVW
0 4 Y248-p HQLVMEGyNWCHDRN
0 7 Y265-p TIFSAPNyCYRCGNQ
0 28 K283-ub MELDDTLkySFLQFD
0 19 Y284-p ELDDTLkySFLQFDP
3 9 T304-p EPHVTRRtPDyFl__
50 0 Y307-p VTRRtPDyFl_____
6 0 L309-me RRtPDyFl_______
  mouse

 
K4 ____MDEKLFTkELD
K8-ub MDEKLFTkELDQWIE
K21-ub IEQLNECkQLSESQV
S26 ECkQLSESQVkSLCE
K29-ub QLSESQVkSLCEKAK
K34 QVkSLCEKAKEILTk
K41-ac KAKEILTkESNVQEV
K41-ub KAKEILTkESNVQEV
K74-ub ELFRIGGkSPDTNYL
K136-ub FYDECLRkYGNANVW
Y248 HQLVMEGYNWCHDRN
Y265 TIFSAPNYCYRCGNQ
K283-ub MELDDTLkySFLQFD
Y284-p ELDDTLkySFLQFDP
T304-p EPHVTRRtPDyFl__
Y307-p VTRRtPDyFl_____
L309-me RRtPDyFl_______
  rat

 
K4-ac ____MDEkLFTkELD
K8-ub MDEkLFTkELDQWIE
K21-ub IEQLNECkQLSESQV
S26 ECkQLSESQVKSLCE
K29 QLSESQVKSLCEKAK
K34 QVKSLCEKAKEILTk
K41-ac KAKEILTkESNVQEV
K41-ub KAKEILTkESNVQEV
K74 ELFRIGGKSPDTNYL
K136 FYDECLRKYGNANVW
Y248-p HQLVMEGyNWCHDRN
Y265 TIFSAPNYCYRCGNQ
K283-ub MELDDTLkySFLQFD
Y284-p ELDDTLkySFLQFDP
T304-p EPHVTRRtPDyFl__
Y307-p VTRRtPDyFl_____
L309-me RRtPDyFl_______
  pig

 
K4 ____MDEKVFTKELD
K8 MDEKVFTKELDQWIE
K21 IEQLNECKQLSESQV
S26 ECKQLSESQVKSLCE
K29 QLSESQVKSLCEKAK
K34 QVKSLCEKAKEILTK
K41 KAKEILTKESNVQEV
K41 KAKEILTKESNVQEV
K74 ELFRIGGKSPDTNYL
K136 FYDECLRKYGNANVW
Y248 HQLVMEGYNWCHDRN
Y265 TIFSAPNYCYRCGNQ
K283 MELDDTLKYSFLQFD
Y284 ELDDTLKYSFLQFDP
T304 EPHVTRRTPDyFL__
Y307-p VTRRTPDyFL_____
L309 RRTPDyFL_______
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