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Protein Page:
SUV39H1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SUV39H1 Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, KIAA1967/DBC1, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. In case of infection, interacts with HTLV-1 Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR. Interacts (via SET domain) with MECOM; enhances MECOM transcriptional repression activity. Inhibited by S-adenosyl-L-homocysteine. Negatively regulated by KIAA1967/DBC1. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. Note: This description may include information from UniProtKB.
Protein type: Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase
Cellular Component: nucleoplasm; heterochromatin; chromatin silencing complex; nuclear lamina; condensed nuclear chromosome; nucleus; chromosome, pericentric region
Molecular Function: histone methyltransferase activity; protein binding; zinc ion binding; S-adenosylmethionine-dependent methyltransferase activity; histone lysine N-methyltransferase activity (H3-K9 specific); protein N-terminus binding; chromatin binding; histone-lysine N-methyltransferase activity
Biological Process: chromatin silencing at rDNA; establishment and/or maintenance of chromatin architecture; viral reproduction; transcription, DNA-dependent; rhythmic process; negative regulation of circadian rhythm; cell cycle; cell differentiation; negative regulation of transcription, DNA-dependent; rRNA processing
Reference #:  O43463 (UniProtKB)
Alt. Names/Synonyms: H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; Histone-lysine N-methyltransferase SUV39H1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; KMT1A; Lysine N-methyltransferase 1A; MG44; Position-effect variegation 3-9 homolog; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1; suppressor of variegation 3-9 homolog 1 (Drosophila); SUV39H; SUV39H1; SUV91
Gene Symbols: SUV39H1
Molecular weight: 47,907 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SUV39H1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

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 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S70-p KWRGYPDsESTWEPR
0 1 K121-ub LANYLVQkAKQRRAL
0 17 K138-ub WEQELNAkRSHLGRI
0 1 T146-p RSHLGRItVENEVDL
0 1 R214 DQGQVRLRAGLPIYE
1 25 S391-p GLAGLPGsPKKRVRI
0 1 K409 CGTESCRKYLF____
  mouse

 
S70 KWRGYPDSENTWEPR
K121 LANYLVQKAKQRRAL
K138 WEQELNAKRSHLGRI
T146 RSHLGRITVENEVDL
K214-ub DQGQVRLkAGQPIYE
S391-p GLAGLPGsPKKRVRI
K409-ac CGTTACRkYLF____
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