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Protein Page:
GNL3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GNL3 May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis. May interact with p53/TP53 via its basic domain. Increased levels in lung tissue in cancer patients. Belongs to the MMR1/HSR1 GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Cell cycle regulation; Hydrolase
Cellular Component: nucleoplasm; extracellular space; membrane; nucleolus; nucleus
Molecular Function: GTPase activity; protein binding; GTP binding
Biological Process: cell proliferation; GTP catabolic process; ribosome biogenesis and assembly; regulation of cell proliferation
Reference #:  Q9BVP2 (UniProtKB)
Alt. Names/Synonyms: C77032; E2-induced gene 3 protein; E2IG3; estradiol-induced nucleotide binding protein; GNL3; guanine nucleotide binding protein-like 3 (nucleolar); Guanine nucleotide-binding protein-like 3; MGC800; NNP47; Novel nucleolar protein 47; NS; Nucleolar GTP-binding protein 3; Nucleostemin
Gene Symbols: GNL3
Molecular weight: 61,993 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GNL3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K5-ac ___MKRPkLKKASKR
0 3 K17-ac SKRMTCHkRYKIQKK
0 1 K79-ac EELKQQQkLDRQKEL
0 11 N95 KKRKLETNPDIKPSN
0 1 S101 TNPDIKPSNVEPMEK
0 1 P105 IKPSNVEPMEKEFGL
0 1 - gap
0 1 K171-ub AIVQSGQkKLVLILN
1 1 Y194-p NLESWLNyLkkELPT
0 2 K196-ub ESWLNyLkkELPTVV
0 2 K197-ub SWLNyLkkELPTVVF
0 1 K237-ac RSEVCFGkEGLWkLL
0 7 K237-ub RSEVCFGkEGLWkLL
0 1 K242-ub FGkEGLWkLLGGFQE
0 11 K253-ub GFQETCSkAIRVGVI
0 3 K267-ub IGFPNVGkSSIINsL
0 1 S273-p GkSSIINsLkQEQMC
0 1 K275-ub SSIINsLkQEQMCNV
0 1 T289-p VGVSMGLtRSMQVVP
0 3 K332-ub PASIEVVkPMEAASA
0 1 T366-p RNSLEFFtVLAQRRG
0 1 K377-ub QRRGMHQkGGIPNVE
0 1 I380 GMHQkGGIPNVEGAA
0 1 K444-ub AQSIRAIkGPHLANS
0 1 L473 EKDIHEELPKRKERK
0 3 S490-p EREDDKDsDQEtVDE
0 1 T494-p DKDsDQEtVDEEVDE
0 1 S503-p DEEVDENsSGMFAAE
0 4 S504 EEVDENsSGMFAAEE
0 1 F507 DENsSGMFAAEEtGE
0 3 T512-p GMFAAEEtGEALsEE
0 25 L516 AEEtGEALsEETTAG
0 1 S517-p EEtGEALsEETTAGE
0 2 T520 GEALsEETTAGEQST
0 1 T521 EALsEETTAGEQSTR
0 4 S529-p AGEQSTRsFILDKII
0 13 Y542-p IIEEDDAyDFsTDyV
0 2 S545-p EDDAyDFsTDyV___
0 4 Y548-p AyDFsTDyV______
  mouse

 
K5 ___MKRPKLKKASKR
K17 SKRMTCHKRYKIQKK
K79 EELKQQQKLDRQKEQ
S95-p RKRKLEVsPGDEQSN
S101 VsPGDEQSNVETREE
T105 DEQSNVETREESDEP
S109 NVETREESDEPKRKK
K169 AVIQSGSKKLILVLN
Y192 NLENWLNYLNKELPT
N194 ENWLNYLNKELPTVV
K195 NWLNYLNKELPTVVF
K232 QSKICCGKEALWKLL
K232 QSKICCGKEALWKLL
K237 CGKEALWKLLGDFQQ
K248 DFQQSCGKDIQVGVI
K262 IGFPNVGKSSVINSL
S268 GKSSVINSLKQEWIC
K270 SSVINSLKQEWICNV
T284 VGISMGLTRSMQIVP
R327 PASIEELRPLEAASA
T361 KDSLHFFTKLAQRRG
K372 QRRGLHQKGGsPNVE
S375-p GLHQKGGsPNVESAA
K439 AHSIQVLKGPHLTNR
S468-p EKDIVEEsPRQTEDK
- gap
N483 QDADDQENGSGERNA
I492 SGERNAEIsDVAPVE
S493-p GERNAEIsDVAPVEE
A496 NAEIsDVAPVEEtRE
T501-p DVAPVEEtRELsPEQ
S505-p VEEtRELsPEQstAG
P506 EEtRELsPEQstAGK
S509-p RELsPEQstAGKPSD
T510-p ELsPEQstAGKPSDG
S518 AGKPSDGSSALDRAS
Y531 ASQEDETYDFTTDYI
T534 EDETYDFTTDYI___
Y537 TYDFTTDYI______
  rat

 
K5 ___MKRPKLKKASKR
K17 SKRMTCHKRYKIQKK
K79 EELKQQQKLDRQKEQ
S95-p RKRKLEIsPDDEQsN
S101-p IsPDDEQsNVEtQEE
T105-p DEQsNVEtQEEsDEP
S109-p NVEtQEEsDEPKIKK
K169 AVIQSGCKKLVLVLN
Y192 NLENWLTYLNKELPT
N194 ENWLTYLNKELPTVV
K195 NWLTYLNKELPTVVF
K232 QSKLCCGKEALWKLL
K232 QSKLCCGKEALWKLL
K237 CGKEALWKLLGGFQQ
K248 GFQQSCGKGVQVGVV
K262 VGFPNVGKSSIINSL
S268 GKSSIINSLKQERIC
K270 SSIINSLKQERICSV
T284 VGVSMGLTRSMQIVP
R327 PASIEVLRPLEAASA
T361 KDSLDFFTKLAQRRG
K372 QRRGLHQKGGSPNVE
S375 GLHQKGGSPNVESAA
K439 AHSIQVLKGPHLTNK
S468 EKDIPEESPKQTEDQ
- gap
H483 QDGDDQEHVTGEKNA
I492 TGEKNAEISDVtPVE
S493 GEKNAEISDVtPVEE
T496-p NAEISDVtPVEETRE
T501 DVtPVEETREMsPGQ
S505-p VEETREMsPGQSTAS
P506 EETREMsPGQSTASK
S509 REMsPGQSTASKPSD
T510 EMsPGQSTASKPSDR
S518 ASKPSDRSFILDKMS
Y531 MSEEDDAYDFTTDYI
T534 EDDAYDFTTDYI___
Y537 AYDFTTDYI______
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