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HSP27 (mouse)

Overview HSP27 a small heat shock protein that is regulated both transcriptionally and posttranslationally. Modulates actin polymerization and reorganization. Its expression level increases several-fold in response to stress and is phosphorylated by MAPKAP kinase 2. Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Chaperone Cellular Component: proteasome complex; cell surface; cytoskeleton; contractile fiber; cytoplasm; plasma membrane; intracellular; Z disc; nucleus Molecular Function: protein kinase C inhibitor activity; ubiquitin binding; protein kinase C binding; protein kinase binding Biological Process: positive regulation of interleukin-1 beta production; positive regulation of tumor necrosis factor biosynthetic process; blood vessel endothelial cell migration; response to stress; negative regulation of protein kinase activity; angiogenesis; regulation of I-kappaB kinase/NF-kappaB cascade; response to unfolded protein; negative regulation of apoptosis Reference #:  P14602 (UniProtKB) Alt. Names/Synonyms: 27kDa; Growth-related 25 kDa protein; Heat shock 25 kDa protein; Heat shock 27 kDa protein; heat shock 27kDa protein 1; heat shock protein 1; Heat shock protein beta-1; heat shock protein, 25 kDa; HSP 25; HSP 27; Hsp25; Hsp27; HspB1; OTTMUSP00000028918; p25 Gene Symbols: Hspb1 Molecular weight: 23,014 Da Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states CST Pathways:  Inhibition of Apoptosis  |  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HSP27 3Q9P - A=90-171 (human) 3Q9Q - A/B=90-171 (human)

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	Sites Implicated In
apoptosis, induced: S15‑p apoptosis, inhibited: S86‑p activation: S15‑p, S86‑p intracellular localization: S15‑p, S86‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	4		S9	TERRVPFSLLRsPsW
0	3		R12	RVPFSLLRsPsWEPF
0	3		S13-p	VPFSLLRsPsWEPFR
33	60		S15-p	FSLLRsPsWEPFRDW
0	8		Y23	WEPFRDWYPAHSRLF
0	1		S27	RDWYPAHSRLFDQAF
0	1		R38	DQAFGVPRLPDEWSQ
0	4		Y55	SAAGWPGYVRPLPAA
0	13		T63	VRPLPAATAEGPAAV
0	1		T71-p	AEGPAAVtLAAPAFs
0	12		F77	VtLAAPAFsRALNRQ
1	5		S78-p	tLAAPAFsRALNRQL
22	36		N82	PAFsRALNRQLssGV
44	310		S86-p	RALNRQLssGVsEIR
1	26		S87-p	ALNRQLssGVsEIRQ
1	3		S90-p	RQLssGVsEIRQTAD
1	2		S102	TADRWRVSLDVNHFA
0	35		K116-u	APEELTVkTkEGVVE
1	2		T117	PEELTVkTkEGVVEI
0	45		K118-u	EELTVkTkEGVVEIT
0	1		T125	kEGVVEITGKHEERQ
0	7		K127	GVVEITGKHEERQDE
0	14		K127	GVVEITGKHEERQDE
0	25		Y137	ERQDEHGYIsRCFTR
0	6		S139-p	QDEHGYIsRCFTRkY
0	5		T143	GYIsRCFTRkYtLPP
0	1		K145-u	IsRCFTRkYtLPPGV
0	2		Y146	sRCFTRkYtLPPGVD
2	12		T147-p	RCFTRkYtLPPGVDP
0	6		T178	APLPKAVTQSAEITI
1	0		S180	LPKAVTQSAEITIPV
0	51		K202-u	IGGPEAGkSEQSGAK
0	5		S203	GGPEAGkSEQSGAK_
0	53		K209	kSEQSGAK_______
0	3		K209	kSEQSGAK_______

	human
S9-p	TERRVPFsLLrGPsW
R12-m1	RVPFsLLrGPsWDPF
G13	VPFsLLrGPsWDPFR
S15-p	FsLLrGPsWDPFRDW
Y23-p	WDPFRDWyPHSRLFD
S26	FRDWyPHSRLFDQAF
R37	DQAFGLPRLPEEWSQ
Y54-p	GGSSWPGyVRPLPPA
S65-p	LPPAAIEsPAVAAPA
A69	AIEsPAVAAPAysRA
Y73-p	PAVAAPAysRALsRQ
S74-p	AVAAPAysRALsRQL
S78-p	PAysRALsRQLssGV
S82-p	RALsRQLssGVsEIR
S83-p	ALsRQLssGVsEIRH
S86-p	RQLssGVsEIRHTAD
S98-p	TADRWRVsLDVNHFA
K112-u	APDELTVktkDGVVE
T113-p	PDELTVktkDGVVEI
K114-u	DELTVktkDGVVEIt
T121-p	kDGVVEItGkHEERQ
K123-a	GVVEItGkHEERQDE
K123-u	GVVEItGkHEERQDE
Y133-p	ERQDEHGyIsRCFtR
S135-p	QDEHGyIsRCFtRKy
T139-p	GyIsRCFtRKytLPP
K141	IsRCFtRKytLPPGV
Y142-p	sRCFtRKytLPPGVD
T143-p	RCFtRKytLPPGVDP
T174-p	APMPKLAtQsNEITI
S176-p	MPKLAtQsNEITIPV
K198-u	LGGPEAAksDETAAk
S199-p	GGPEAAksDETAAk_
K205-a	ksDETAAk_______
K205-u	ksDETAAk_______

	rat
S9-p	TERRVPFsLLRsPsW
R12	RVPFsLLRsPsWEPF
S13-p	VPFsLLRsPsWEPFR
S15-p	FsLLRsPsWEPFRDW
Y23	WEPFRDWYPAHsRLF
S27-p	RDWYPAHsRLFDQAF
R38-m1	DQAFGVPrFPDEWSQ
Y55	SSAGWPGYVRPLPAA
T63	VRPLPAATAEGPAAV
T71	AEGPAAVTLARPAFS
F77	VTLARPAFSRALNRQ
S78	TLARPAFSRALNRQL
N82	PAFSRALNRQLssGV
S86-p	RALNRQLssGVsEIR
S87-p	ALNRQLssGVsEIRQ
S90-p	RQLssGVsEIRQTAD
S102-p	TADRWRVsLDVNHFA
K116	APEELTVKtKEGVVE
T117-p	PEELTVKtKEGVVEI
K118	EELTVKtKEGVVEIT
T125	KEGVVEITGKHEERQ
K127	GVVEITGKHEERQDE
K127	GVVEITGKHEERQDE
Y137	ERQDEHGYISRCFTR
S139	QDEHGYISRCFTRKY
T143	GYISRCFTRKYtLPP
K145	ISRCFTRKYtLPPGV
Y146	SRCFTRKYtLPPGVD
T147-p	RCFTRKYtLPPGVDP
T178	APLPKAVTQSAEITI
S180	LPKAVTQSAEITIPV
-	gap
S200	AQIGGPESEQSGAK_
K206	ESEQSGAK_______
K206	ESEQSGAK_______

	pig
S9	TERRVPFSLLRSPSW
R12	RVPFSLLRSPSWDPF
S13	VPFSLLRSPSWDPFR
S15	FSLLRSPSWDPFRDW
Y23	WDPFRDWYPAHSRLF
S27	RDWYPAHSRLFDQAF
R38	DQAFGLPRLPEEWSQ
Y55	SHSGWPGYVRPLPPP
A63	VRPLPPPAIEGPAAV
A71	IEGPAAVAAPAYSRL
Y75	AAVAAPAYSRLLSRQ
S76	AVAAPAYSRLLSRQL
S80	PAYSRLLSRQLsSGV
S84-p	RLLSRQLsSGVSEIQ
S85	LLSRQLsSGVSEIQQ
S88	RQLsSGVSEIQQTAD
S100	TADRWRVSLDVNHFA
K114	APEELTVKTKDGVVE
T115	PEELTVKTKDGVVEI
K116	EELTVKTKDGVVEIT
T123	KDGVVEITGKHEERQ
K125	GVVEITGKHEERQDE
K125	GVVEITGKHEERQDE
F135	ERQDEHGFISRCFTR
S137	QDEHGFISRCFTRKY
T141	GFISRCFTRKYTLPP
K143	ISRCFTRKYTLPPGV
Y144	SRCFTRKYTLPPGVD
T145	RCFTRKYTLPPGVDP
T176	APLPKPATQSAEITI
S178	LPKPATQSAEITIPV
K200	LGGTEAGKSEKPGTK
S201	GGTEAGKSEKPGTK_
K207	KSEKPGTK_______
K207	KSEKPGTK_______

	hamster
S9	TERRVPFSLLRSPsW
R12	RVPFSLLRSPsWEPF
S13	VPFSLLRSPsWEPFR
S15-p	FSLLRSPsWEPFRDW
Y23	WEPFRDWYPAHSRLF
S27	RDWYPAHSRLFDQAF
R38	DQAFGVPRLPDEWSQ
Y55	SAAGWPGYVRPLPAA
T63	VRPLPAATAEGPAAV
A71	AEGPAAVALAAPLAA
F81	APLAAPAFHRALNRQ
H82	PLAAPAFHRALNRQL
N86	PAFHRALNRQLsSGV
S90-p	RALNRQLsSGVSEIR
S91	ALNRQLsSGVSEIRQ
S94	RQLsSGVSEIRQTAD
S106	TADRWRVSLDVNHFA
K120	APEELTVKTKEGVVE
T121	PEELTVKTKEGVVEI
K122	EELTVKTKEGVVEIT
T129	KEGVVEITGKHEERQ
K131	GVVEITGKHEERQDE
K131	GVVEITGKHEERQDE
Y141	ERQDEHGYISRCFTR
S143	QDEHGYISRCFTRKY
T147	GYISRCFTRKYTLPP
K149	ISRCFTRKYTLPPGV
Y150	SRCFTRKYTLPPGVD
T151	RCFTRKYTLPPGVDP
T182	APLPKTATQSAEITI
S184	LPKTATQSAEITIPV
K206	IGGQEAGKSEQSGAK
S207	GGQEAGKSEQSGAK_
K213	KSEQSGAK_______
K213	KSEQSGAK_______

	chicken
T9	AERRVPFTFLTSPsW
T12	RVPFTFLTSPsWEPF
S13	VPFTFLTSPsWEPFR
S15-p	FTFLTSPsWEPFRDW
Y23	WEPFRDWYHGSRLFD
S26	FRDWYHGSRLFDQSF
H37	DQSFGMPHIPEDWYK
Y54	SGSAWPGYFRLLPSE
S62	FRLLPSESALLPAPG
-	gap
Y72	LPAPGSPYGRALsEL
G73	PAPGSPYGRALsELS
S77-p	SPYGRALsELSsGIS
S80	GRALsELSsGISEIR
S81-p	RALsELSsGISEIRQ
S84	sELSsGISEIRQSAD
T96	SADSWKVTLDVNHFA
K110	APEELVVKTKDNIVE
T111	PEELVVKTKDNIVEI
K112	EELVVKTKDNIVEIT
T119	KDNIVEITGKHEEKQ
K121	NIVEITGKHEEKQDE
K121	NIVEITGKHEEKQDE
F131	EKQDEHGFISRCFTR
S133	QDEHGFISRCFTRKY
T137	GFISRCFTRKYTLPP
K139	ISRCFTRKYTLPPGV
Y140	SRCFTRKYTLPPGVE
T141	RCFTRKYTLPPGVEA
I172	APLPKPAIQSSEITI
S174	LPKPAIQSSEITIPV
K186	IPVTVEAKKEEPAKK
K187	PVTVEAKKEEPAKK_
K193	KKEEPAKK_______
K193	KKEEPAKK_______

	dog
S9	TERRVPFSLLRSPsW
R12	RVPFSLLRSPsWDPF
S13	VPFSLLRSPsWDPFR
S15-p	FSLLRSPsWDPFRDW
Y23	WDPFRDWYPAHSRLF
S27	RDWYPAHSRLFDQAF
R38	DQAFGLPRLPEEWAQ
Y55	GHSGWPGYVRPIPPA
-	gap
A70	VEGPAAAAAAAAPAY
Y77	AAAAAPAYsRALSRQ
S78-p	AAAAPAYsRALSRQL
S82	PAYsRALSRQLsSGV
S86-p	RALSRQLsSGVSEIR
S87	ALSRQLsSGVSEIRQ
S90	RQLsSGVSEIRQTAD
S102	TADRWRVSLDVNHFA
K116	APEELTVKTKDGVVE
T117	PEELTVKTKDGVVEI
K118	EELTVKTKDGVVEIT
T125	KDGVVEITGKHEERQ
K127	GVVEITGKHEERQDE
K127	GVVEITGKHEERQDE
Y137	ERQDEHGYISRRLTP
S139	QDEHGYISRRLTPKY
T143	GYISRRLTPKYTLPP
K145	ISRRLTPKYTLPPGV
Y146	SRRLTPKYTLPPGVD
T147	RRLTPKYTLPPGVDP
T178	APMPKPATQSAEITI
S180	MPKPATQSAEITIPV
K202	IGGPEAGKSEQSGAK
S203	GGPEAGKSEQSGAK_
K209	KSEQSGAK_______
K209	KSEQSGAK_______

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