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EAPP (human)

Overview EAPP May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. Interacts with E2F1. The C-terminal half binds the N- terminal of E2F1. Also interacts with E2F2 and E2F3, but not E2F4. Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts. Note: This description may include information from UniProtKB. Cellular Component: Golgi apparatus; cytoplasm; nucleus Biological Process: positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of cell proliferation Reference #:  Q56P03 (UniProtKB) Alt. Names/Synonyms: BM036; C14orf11; E2F-associated phosphoprotein; EAPP; FLJ20578; MGC4957 Gene Symbols: EAPP Molecular weight: 32,762 Da Basal Isoelectric point: 5  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below EAPP

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S17-p	PYAVEEPsDEEPALs
0	1		S24-p	sDEEPALsssEDEVD
0	1		S25-p	DEEPALsssEDEVDV
0	1		S26-p	EEPALsssEDEVDVL
0	1		T50-p	KLIRECLtGEsEsss
0	1		S53-p	RECLtGEsEsssEDE
0	2		S55-p	CLtGEsEsssEDEFE
0	1		S56-p	LtGEsEsssEDEFEK
0	2		S57-p	tGEsEsssEDEFEKE
0	1		S87-p	LSSLGTGsSSGNGkV
0	14		K93-u	GsSSGNGkVATAPTR
0	17		S109-p	YDDIYFDsDsEDEDR
0	17		S111-p	DIYFDsDsEDEDRAV
0	1		A117	DsEDEDRAVQVTKKK
0	2		T121	EDRAVQVTKKKKKKQ
0	1		K143	ELLYDPEKDNRDQAW
0	1		Y220-p	NKEEVLRyKASENRK

	mouse
S17	PYAVEEPSDEEPALS
S24	SDEEPALSSSEDELD
S25	DEEPALSSSEDELDV
S26	EEPALSSSEDELDVL
T50	KLIRECLTGESEsSs
S53	RECLTGESEsSsEDE
S55-p	CLTGESEsSsEDEFE
S56	LTGESEsSsEDEFEK
S57-p	TGESEsSsEDEFEKE
S87	LSSLGTGSSSGVAkV
K93-u	GSSSGVAkVGGVTEK
S109-p	YDEIYFDsDsEDEDK
S111-p	EIYFDsDsEDEDKtV
T117-p	DsEDEDKtVtKKKKK
T119-p	EDEDKtVtKKKKKKQ
K141	ELLYDPEKDNRDQAW
Y219	NREEVLRYKNPENRR

	rat
S17	PYAVEEPSDEEPALS
S24	SDEEPALSSSEDEVD
S25	DEEPALSSSEDEVDV
S26	EEPALSSSEDEVDVL
T50	KLIRECLTGESESSE
S53	RECLTGESESSEDEF
S55	CLTGESESSEDEFEK
S56	LTGESESSEDEFEKE
-	gap
S86	LSSLGTGSSSGVAKV
K92	GSSSGVAKVGGVTTK
S108	YDAVYFDSDSEDEDK
S110	AVYFDSDSEDEDKAV
A116	DSEDEDKAVTKKKKK
T118	EDEDKAVTKKKKKKQ
K140-u	ELLYDPEkDSRDQAW
Y218	NREEVLRYKNSDNRK

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